Product image of Karvezide (Hydrochlorothiazide, Irbesartan) supplied by GNH India

Karvezide

Active Ingredient:
Hydrochlorothiazide, Irbesartan
Origin:
EU

Karvezide (Hydrochlorothiazide, Irbesartan)

Irbesartan and Hydrochlorothiazide, the active ingredients in Karvezide, are an angiotensin II receptor blocker and a thiazide diuretic presented as tablets for oral use. They treat hypertension in adult patients by lowering blood pressure and reducing cardiovascular risk.

GNH India supplies Karvezide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable logistics for global distribution. The company adheres to stringent manufacturing standards and provides comprehensive support to healthcare providers across multiple regions.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

  • Karvezide acts on the renin‑angiotensin‑aldosterone system and promotes diuresis to manage high blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure, helping achieve target levels.
  • Essential hypertension: provides effective blood pressure control in primary hypertension.
  • High blood pressure: lowers cardiovascular risk by maintaining normal pressure.

How It Works

  • Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing vasoconstriction and aldosterone secretion, while hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes. The combined actions decrease peripheral vascular resistance and plasma volume, resulting in sustained reduction of arterial blood pressure. These effects are additive, providing a synergistic antihypertensive response with a favorable impact on fluid balance and vascular tone.

Side Effects

Karvezide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness: light‑headedness especially after standing.
  • Increased urination: due to diuretic effect.
  • Electrolyte imbalance: low potassium or sodium levels.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, potentially airway obstruction.
  • Severe allergic reaction: rash, itching, difficulty breathing.
  • Acute kidney injury: sudden loss of kidney function.

Precautions & Warnings

  • When prescribing Karvezide, clinicians should consider several safety factors.
  • Renal impairment: monitor kidney function and adjust dose if needed.
  • Electrolyte disturbances: check serum potassium and sodium regularly.
  • Pregnancy: contraindicated (Category D) due to risk of fetal harm.
  • Concomitant potassium‑sparing agents: avoid to prevent hyperkalemia.
  • Gout: thiazide component may increase uric acid levels.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Karvezide can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of dangerous hyperkalemia.
  • ACE inhibitors: additive effect on potassium and renal function.
  • Lithium: thiazide component can raise lithium levels, causing toxicity.

Moderate Interactions (Monitor Closely)

  • Other antihypertensives: may cause excessive blood pressure reduction.
  • CYP2C9 inhibitors (e.g., fluconazole): increase irbesartan plasma concentrations.

Frequently Asked Questions

Karvezide is a fixed‑dose combination of irbesartan and hydrochlorothiazide indicated for the treatment of hypertension in adult patients. It helps lower blood pressure by blocking the renin‑angiotensin system and promoting diuresis.

Irbesartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. This leads to reduced peripheral vascular resistance and lower arterial pressure.

Hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes. The resulting decrease in plasma volume contributes to blood‑pressure reduction.

The dosage of Karvezide is individualized; a qualified prescriber determines the appropriate strength and frequency based on the patient’s blood‑pressure response, renal function, and other clinical factors.

Karvezide is classified as pregnancy category D, indicating evidence of risk to the fetus; it should not be used during pregnancy. Limited data exist for breastfeeding, and the drug is generally not recommended for nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapies, Karvezide combines an angiotensin II receptor blocker with a thiazide diuretic, offering complementary mechanisms that often achieve better blood‑pressure control than either component alone. It may be preferred when monotherapy does not reach target levels.

Karvezide tablets should be stored at ambient temperature, below 25 °C, in the original container, protected from moisture and light. Do not store in the bathroom or near heat sources.

Karvezide is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

The most serious adverse reactions include angioedema, severe allergic reactions, and acute kidney injury. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, difficulty breathing, or sudden loss of kidney function.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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