Product image of Kastia (Rosuvastatin) supplied by GNH India

Kastia

Active Ingredient:
Rosuvastatin
Origin:
EU

Kastia (Rosuvastatin)

Rosuvastatin, the active ingredient in Kastia, is a HMG‑CoA reductase inhibitor presented as an oral tablet for oral use. It lowers elevated cholesterol and triglyceride levels and is used to reduce cardiovascular risk in patients with hypercholesterolemia or mixed dyslipidaemia.

GNH India supplies Kastia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Iberia, S.A.

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Indications & Clinical Uses

Rosuvastatin is indicated for disorders of lipid metabolism and for reducing cardiovascular events in at‑risk populations.

  • Hypercholesterolemia: lowers low‑density lipoprotein (LDL) cholesterol to target levels.
  • Hyperlipidemia: reduces total cholesterol, LDL‑C and triglycerides while modestly increasing HDL‑C.
  • Prevention of cardiovascular events in at‑risk patients: decreases the incidence of myocardial infarction, stroke and revascularisation procedures.

How It Works

  • Rosuvastatin inhibits the enzyme HMG‑CoA reductase, the rate‑limiting step in hepatic cholesterol synthesis. This inhibition reduces intracellular cholesterol, leading to up‑regulation of LDL receptors on hepatocytes and increased clearance of circulating LDL particles, thereby lowering plasma cholesterol concentrations.

Side Effects

Rosuvastatin may cause a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Myalgia: muscle aches without weakness.
  • Nausea: occasional gastrointestinal upset.
  • Abdominal discomfort: mild stomach pain or cramping.
  • Elevated liver enzymes: transient increase in ALT/AST.
  • Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with dark urine.
  • Hepatotoxicity: significant rise in liver transaminases or jaundice.
  • Acute renal failure: sudden decrease in kidney function.
  • Allergic reactions: rash, pruritus or angioedema.

Precautions & Warnings

Rosuvastatin should be used with caution in specific clinical situations and according to professional guidelines.

  • Assess liver function: obtain baseline ALT/AST before initiating therapy.
  • Monitor renal function: adjust dose in patients with moderate to severe renal impairment.
  • Evaluate for muscle symptoms: discontinue if unexplained muscle pain or weakness occurs.
  • Avoid use in pregnancy and lactation: safety not established.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture and light.

Avoid Interactions

Rosuvastatin may interact with several concomitant medications, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Cyclosporine: markedly increases rosuvastatin plasma concentrations.
  • Strong CYP2C9 inhibitors (e.g., fluconazole): may raise exposure and risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin): may enhance anticoagulant effect, requiring INR monitoring.
  • Fibrates (gemfibrozil): increase risk of myopathy.
  • Antacids containing aluminium or magnesium: may reduce rosuvastatin absorption if taken simultaneously.

Frequently Asked Questions

Kastia contains rosuvastatin, a statin medication prescribed to lower elevated cholesterol and triglyceride levels. It is used to treat hypercholesterolemia, hyperlipidemia, and to reduce the risk of cardiovascular events such as heart attacks and strokes in patients who are at increased risk.

Rosuvastatin works by inhibiting HMG‑CoA reductase, the key enzyme in the liver responsible for producing cholesterol. This inhibition lowers intracellular cholesterol, prompting the liver to increase the number of LDL receptors, which clear more low‑density lipoprotein cholesterol from the bloodstream.

The appropriate dose of Kastia is determined by the prescribing healthcare professional based on the patient’s clinical condition, cholesterol levels, and response to therapy. Dosage may be adjusted over time to achieve target lipid goals while monitoring safety.

The safety of rosuvastatin in pregnancy and lactation has not been established. It is generally contraindicated for use in pregnant or nursing women because potential risks to the fetus or infant cannot be ruled out. Alternative lipid‑lowering strategies should be considered.

To place an order, submit an enquiry on the Kastia product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Kastia (rosuvastatin) is a high‑potency statin that often achieves greater LDL‑C reductions at lower doses compared with older agents such as simvastatin or pravastatin. Its pharmacokinetic profile provides a longer half‑life, allowing for consistent lipid control, but individual response and tolerability should guide therapy selection.

Kastia tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Kastia is taken orally, usually once daily, with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water and follow any specific instructions regarding timing relative to meals.

The most serious risks include rhabdomyolysis, a rare but severe muscle breakdown that can lead to kidney injury, and significant liver enzyme elevations indicating potential hepatotoxicity. Patients should report unexplained muscle pain, weakness, dark urine, or signs of liver dysfunction promptly.

Kastia should not be used by individuals with known hypersensitivity to rosuvastatin or any component of the formulation, patients with active liver disease, or those who are pregnant or breastfeeding. Caution is also advised for patients with severe renal impairment or those taking interacting medications without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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