Product image of Kastia (Rosuvastatin) supplied by GNH India

Kastia

Active Ingredient:
Rosuvastatin
Origin:
EU

Kastia (Rosuvastatin)

Rosuvastatin, the active ingredient in Kastia, is a HMG‑CoA reductase inhibitor presented as an oral dosage form for oral use. It lowers elevated cholesterol levels and is used to reduce the risk of cardiovascular events in adult patients with hypercholesterolemia.

GNH India supplies Kastia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and consistent product quality across global markets. The company adheres to stringent quality standards and offers comprehensive logistics solutions for timely delivery.

Manufacturer / TM Owner

Medochemie Iberia, S.A.

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Indications & Clinical Uses

Rosuvastatin is indicated for lipid disorders and cardiovascular risk reduction.

  • Hypercholesterolemia: reduces LDL‑cholesterol and total cholesterol levels.
  • Primary prevention of cardiovascular disease: lowers the risk of heart attack and stroke in patients without established disease.
  • Secondary prevention of cardiovascular disease: helps prevent recurrent events in patients with prior myocardial infarction or stroke.

How It Works

  • Rosuvastatin competitively inhibits HMG‑CoA reductase, the key enzyme that catalyzes the conversion of HMG‑CoA to mevalonate, a precursor in cholesterol biosynthesis. By blocking this rate‑limiting step, hepatic cholesterol synthesis declines, leading to up‑regulation of LDL receptors and increased clearance of circulating LDL particles, thereby lowering plasma LDL‑cholesterol and total cholesterol concentrations.

Side Effects

Rosuvastatin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Muscle pain: aching or soreness in limbs.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with potential kidney injury.
  • Elevated liver enzymes: indicating possible hepatic injury.
  • Severe allergic reaction: including rash, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing rosuvastatin, several safety considerations should be observed.

  • Liver function monitoring: assess baseline transaminases and repeat periodically.
  • Renal function assessment: adjust use in patients with severe renal impairment.
  • Muscle symptom evaluation: discontinue if unexplained muscle pain, tenderness or weakness occurs.
  • Pregnancy contraindication: avoid use in pregnancy due to fetal risk (Category X).
  • Concomitant drug review: check for interactions with CYP2C9 inhibitors and other lipid‑lowering agents.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Rosuvastatin interacts with several medicines that can alter its plasma concentration or increase toxicity.

Major Interactions (Avoid)

  • Gemfibrozil: markedly increases rosuvastatin exposure and risk of myopathy.
  • Strong CYP2C9 inhibitors (e.g., azole antifungals): raise rosuvastatin levels.
  • High‑dose niacin: enhances risk of muscle toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may potentiate anticoagulant effect, requiring INR monitoring.
  • Digoxin: increased serum digoxin concentrations have been reported.
  • Other statins: combined therapy can increase risk of adverse muscle events.

Frequently Asked Questions

Kastia contains rosuvastatin, which is prescribed to lower elevated LDL‑cholesterol and total cholesterol in patients with hypercholesterolemia. It is also used to reduce the risk of first‑time cardiovascular events (primary prevention) and to prevent recurrent heart attacks or strokes in patients with established cardiovascular disease (secondary prevention).

Rosuvastatin blocks the enzyme HMG‑CoA reductase, the rate‑limiting step in cholesterol synthesis. Inhibiting this enzyme reduces hepatic production of cholesterol, prompting the liver to increase LDL‑receptor expression and clear more LDL particles from the bloodstream, which results in lower plasma cholesterol levels.

The appropriate dose of Kastia is individualized by the prescribing healthcare professional based on the patient’s cholesterol levels, cardiovascular risk profile, age, renal function, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Rosuvastatin is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as the drug may be excreted in breast milk and affect the infant.

To request Kastia, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kastia (rosuvastatin) is a high‑potency statin that often achieves greater LDL‑cholesterol reductions at lower doses compared with older agents such as simvastatin or pravastatin. Its pharmacokinetic profile provides a longer half‑life, allowing flexible dosing, but clinicians still consider individual patient factors and potential drug interactions when selecting a statin.

Kastia should be stored at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Kastia is taken orally, usually once daily, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

The most serious adverse events linked to rosuvastatin include rhabdomyolysis (severe muscle breakdown), significant elevations in liver enzymes indicating hepatic injury, and rare severe allergic reactions such as anaphylaxis. Patients should report unexplained muscle pain, dark urine, jaundice, or signs of an allergic response promptly.

Kastia should not be used by individuals with known hypersensitivity to rosuvastatin or any component of the formulation, pregnant women, or nursing mothers. Caution is also advised for patients with severe hepatic impairment, active liver disease, or those taking contraindicated medications such as gemfibrozil.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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