Product image of Kastia (Rosuvastatin) supplied by GNH India

Kastia

Active Ingredient:
Rosuvastatin
Origin:
EU

Kastia (Rosuvastatin)

Rosuvastatin, the active ingredient in Kastia, is a HMG‑CoA reductase inhibitor presented as an oral tablet for oral use. It lowers elevated cholesterol levels and is indicated for patients with hypercholesterolemia and for the prevention of cardiovascular events in at‑risk individuals.

GNH India supplies Kastia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Medochemie Iberia, S.A.

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Indications & Clinical Uses

Kastia (rosuvastatin) acts on lipid metabolism pathways to manage cholesterol and reduce cardiovascular risk.

  • Hypercholesterolemia: lowers low‑density lipoprotein (LDL) cholesterol and total cholesterol concentrations.
  • Primary prevention of cardiovascular disease: reduces the likelihood of first‑time heart attack or stroke in patients with elevated risk factors.
  • Secondary prevention of cardiovascular disease: helps prevent recurrent cardiovascular events in individuals with established heart disease.

How It Works

  • Rosuvastatin competitively inhibits HMG‑CoA reductase, the key enzyme in hepatic cholesterol synthesis. This inhibition decreases intracellular cholesterol, prompting up‑regulation of LDL receptors on hepatocyte surfaces, which enhances clearance of circulating LDL particles and modestly raises HDL cholesterol, thereby improving overall lipid profile.

Side Effects

Rosuvastatin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Myalgia: muscle aches without weakness.
  • Nausea: occasional gastrointestinal discomfort.
  • Abdominal pain: mild stomach upset.
  • Elevated liver enzymes: transient increase in hepatic function tests.
  • Dizziness: occasional light‑headed sensation.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with dark urine.
  • Hepatotoxicity: significant elevation of liver transaminases.
  • Acute renal failure: sudden loss of kidney function.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • New onset diabetes mellitus: elevated blood glucose levels.
  • Thrombocytopenia: reduced platelet count leading to bleeding risk.

Precautions & Warnings

Before initiating therapy with Kastia, consider the following safety measures.

  • Pregnancy: contraindicated (Category X); avoid use during pregnancy.
  • Breastfeeding: not recommended; assess risk versus benefit.
  • Liver disease: evaluate hepatic function; use with caution.
  • Renal impairment: adjust dosing in severe renal dysfunction.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Rosuvastatin may interact with several medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Cyclosporine: markedly increases rosuvastatin plasma levels.
  • Gemfibrozil: raises risk of myopathy and rhabdomyolysis.
  • Strong CYP2C9 inhibitors (e.g., fluconazole): elevate drug exposure.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin): may enhance anticoagulant effect.
  • Antihypertensives (e.g., amlodipine): modestly increase rosuvastatin concentrations.
  • Niacin: combined use can increase risk of muscle toxicity.
  • Digoxin: potential for increased serum digoxin levels.

Frequently Asked Questions

Kastia contains rosuvastatin, a statin medication prescribed to lower elevated cholesterol levels and to reduce the risk of cardiovascular events in patients with hypercholesterolemia, as well as for primary and secondary prevention of heart disease and stroke.

Rosuvastatin inhibits the enzyme HMG‑CoA reductase, which is essential for cholesterol synthesis in the liver. This inhibition reduces hepatic cholesterol production, leading to increased expression of LDL receptors and enhanced removal of LDL cholesterol from the bloodstream.

The appropriate dose of Kastia is determined by the prescribing healthcare professional based on the patient’s clinical condition, cholesterol levels, and response to therapy. Dosage adjustments may be required for specific populations such as those with renal or hepatic impairment.

Kastia is classified as pregnancy category X, meaning it is contraindicated during pregnancy because of potential fetal harm. It is also not recommended for breastfeeding mothers, as safety has not been established and the drug may pass into breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kastia (rosuvastatin) is a high‑potency statin that often achieves greater LDL‑cholesterol reductions at lower doses compared with older agents such as simvastatin or pravastatin. Its pharmacokinetic profile provides a longer half‑life, allowing flexible dosing, but individual response and tolerance vary.

Kastia should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Kastia is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

The most serious adverse events include rhabdomyolysis (severe muscle breakdown), significant liver enzyme elevations indicating hepatotoxicity, and rare cases of acute renal failure. Patients should report unexplained muscle pain, dark urine, or jaundice promptly.

Kastia should not be used by individuals who are pregnant, have known hypersensitivity to rosuvastatin or any excipients, or have active liver disease. Caution is also advised for patients with severe renal impairment or those taking contraindicated medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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