Product image of Kataldi (Chlortalidone) supplied by GNH India

Kataldi

Active Ingredient:
Chlortalidone
Origin:
EU

Kataldi (Chlortalidone)

Chlortalidone, the active ingredient in Kataldi, is a thiazide‑like diuretic presented as an oral tablet for oral use. It lowers elevated blood pressure and reduces fluid retention in patients with hypertension or edema.
GNH India supplies Kataldi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

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Indications & Clinical Uses

  • Kataldi, a thiazide‑like diuretic, is employed in the management of conditions related to excess fluid and high blood pressure.
  • Hypertension: reduces systemic vascular resistance and plasma volume, contributing to sustained blood pressure control.
  • Edema: increases urinary excretion of sodium and water, alleviating fluid accumulation in peripheral tissues.

How It Works

  • Chlortalidone acts on the distal convoluted tubule of the nephron, inhibiting the Na+/Cl‑ cotransporter. This blockade reduces sodium and chloride reabsorption, leading to increased urinary excretion of sodium, water, and potassium, which lowers extracellular fluid volume and decreases peripheral vascular resistance, thereby reducing blood pressure.

Side Effects

Common Side Effects

  • Low blood sodium (hyponatremia)
  • Low blood potassium (hypokalemia)
  • Elevated uric acid levels (hyperuricemia)
  • Increased blood glucose levels
  • Dizziness or light‑headedness

Serious or Rare Side Effects

  • Severe electrolyte imbalance requiring medical attention
  • Acute pancreatitis
  • Allergic reactions such as rash, itching, or swelling
  • Blood dyscrasias (e.g., agranulocytosis)
  • Hepatic dysfunction

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor electrolytes: regular blood tests to assess sodium, potassium, and uric acid levels.
  • Assess renal function: evaluate creatinine clearance, especially in patients with existing kidney disease.
  • Evaluate blood pressure: ensure adequate control without excessive hypotension.
  • Use cautiously in diabetes: monitor glucose as chlortalidone may raise blood sugar.
  • Avoid in severe hepatic impairment: liver dysfunction can exacerbate drug accumulation.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Chlortalidone may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Lithium: increased lithium levels and toxicity.
  • NSAIDs: reduced diuretic efficacy and possible renal impairment.
  • ACE inhibitors: heightened risk of hyperkalemia and renal dysfunction.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: additive blood‑pressure lowering effect.
  • Antidiabetic agents: possible increase in blood glucose.
  • Anticoagulants: enhanced anticoagulant effect, requiring INR monitoring.

Frequently Asked Questions

Kataldi contains chlortalidone, a thiazide‑like diuretic indicated for the treatment of hypertension and for reducing fluid overload associated with edema. It helps lower high blood pressure and promotes the elimination of excess water from the body.

Chlortalidone blocks the sodium‑chloride cotransporter in the distal convoluted tubule of the kidney. This inhibition reduces reabsorption of sodium and chloride, leading to increased excretion of sodium, water, and potassium, which lowers blood volume and peripheral resistance, thereby decreasing blood pressure.

The appropriate dose of Kataldi is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and renal function. Dosage adjustments are made to achieve optimal blood‑pressure control while minimizing side effects.

Safety data for chlortalidone in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Kataldi, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kataldi (chlortalidone) is a thiazide‑like diuretic, often considered more potent and longer‑acting than hydrochlorothiazide. It provides effective blood‑pressure reduction and fluid removal, but may have a higher incidence of electrolyte disturbances, requiring closer monitoring.

Kataldi should be stored at room temperature, below 25 °C, in its original container. Keep the tablets away from moisture, heat, and direct sunlight to maintain stability and potency.

Kataldi is taken orally, usually with a full glass of water. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal discomfort. Follow the prescribing clinician’s instructions regarding timing and frequency.

The most serious risks include severe electrolyte imbalances such as hyponatremia or hypokalemia, acute kidney injury, and rare but serious reactions like pancreatitis or severe allergic responses. Prompt medical attention is required if symptoms of these conditions appear.

Kataldi is contraindicated in patients with anuria, severe renal impairment, known hypersensitivity to chlortalidone or other sulfonamide drugs, and in individuals with severe hepatic dysfunction. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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