Product image of Katena (Gabapentin) supplied by GNH India

Katena

Active Ingredient:
Gabapentin
Origin:
EU

Katena (Gabapentin)

Gabapentin, the active ingredient in Katena, is a gabapentinoid presented as an oral tablet for oral use. It is employed as an adjunctive therapy for epilepsy and for the management of neuropathic pain conditions such as post‑herpetic neuralgia and restless‑legs syndrome.

GNH India supplies Katena as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for each shipment. Customers benefit from reliable lead times and comprehensive after‑sales support across all regions.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

  • Gabapentin is used to treat several neurological and pain‑related conditions.
  • Epilepsy (adjunctive therapy): Reduces seizure frequency when added to existing antiepileptic regimens.
  • Neuropathic pain: Alleviates pain associated with diabetic peripheral neuropathy and other nerve‑damage conditions.
  • Postherpetic neuralgia: Decreases chronic pain following shingles infection.
  • Restless legs syndrome: Improves uncomfortable sensations and urges to move the legs.

How It Works

  • Gabapentin binds with high affinity to the α2δ subunit of voltage‑gated calcium channels in neuronal membranes. This interaction reduces calcium influx during depolarization, thereby decreasing the release of excitatory neurotransmitters such as glutamate, substance P and norepinephrine. The net effect is a dampening of neuronal hyper‑excitability that underlies seizures and neuropathic pain signaling.

Side Effects

Gabapentin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Somnolence: increased sleepiness or fatigue.
  • Peripheral edema: swelling of the lower extremities.
  • Nausea: mild stomach upset.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Mood changes: depression, anxiety, or suicidal thoughts.
  • Respiratory depression: slowed breathing, especially when combined with depressants.

Precautions & Warnings

  • When prescribing gabapentin, clinicians should consider several safety and handling measures.
  • Renal impairment: adjust dose based on creatinine clearance.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Pregnancy: use only if potential benefit outweighs risk, as safety data are limited.
  • Elderly patients: start at low dose and titrate slowly due to increased sensitivity.
  • Suicidality: observe for new or worsening depressive symptoms.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Gabapentin can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce gabapentin absorption; separate dosing by at least 2 hours.
  • Opioids: combined use may increase risk of respiratory depression and profound sedation.

Moderate Interactions (Monitor Closely)

  • CNS depressants (benzodiazepines, barbiturates): may enhance sedative effects; monitor level of consciousness.
  • Diuretics: may increase risk of peripheral edema; observe for swelling.
  • Anticonvulsants (carbamazepine, phenytoin): may lower gabapentin plasma concentrations; consider dose adjustment.

Frequently Asked Questions

Katena contains gabapentin, which is prescribed as an adjunctive treatment for epilepsy and to relieve neuropathic pain conditions such as post‑herpetic neuralgia and restless‑legs syndrome. It may also be used for other nerve‑related pain disorders under a physician’s guidance.

Gabapentin binds to the α2δ subunit of voltage‑gated calcium channels in the central nervous system. This binding reduces calcium entry into neurons, limiting the release of excitatory neurotransmitters and thereby decreasing neuronal hyper‑excitability that contributes to seizures and pain signaling.

The appropriate dose of Katena is individualized by the prescribing clinician based on the patient’s medical condition, renal function, age, and response to therapy. No fixed regimen is provided here; the prescriber will set the dosage and titration schedule.

Safety data for gabapentin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified health professional.

To request Katena, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to gabapentin is pregabalin, another gabapentinoid. Both share a similar mechanism of reducing calcium‑channel‑mediated neurotransmitter release, but pregabalin often has higher bioavailability and may require different dosing schedules. Choice between them depends on efficacy, tolerability, cost and physician preference.

Katena should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat and direct sunlight to maintain potency throughout its shelf life.

Katena is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include severe allergic reactions (rash, swelling, breathing difficulty), mood alterations such as depression or suicidal thoughts, and respiratory depression, especially when combined with other central nervous system depressants. Patients should seek immediate medical attention if any of these occur.

Katena is contraindicated in individuals with known hypersensitivity to gabapentin or any excipients in the tablet. Caution is advised for patients with severe renal impairment, uncontrolled psychiatric illness, or those taking multiple CNS depressants. A prescriber must evaluate suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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