Product image of Katul (Drospirenone, Ethinylestradiol) supplied by GNH India

Katul

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Katul (Drospirenone, Ethinylestradiol)

Drospirenone and ethinylestradiol, the active ingredients in Katul, are a combined oral contraceptive presented as an oral tablet for oral use. The product belongs to the drug class of combined oral contraceptives and is prescribed for women of reproductive age to prevent pregnancy by suppressing ovulation.

GNH India supplies Katul as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, sourcing the product from EU‑authorized manufacturers and adhering to stringent quality standards. The company provides regulatory documentation and supports import logistics for global distribution.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Katul, a combined oral contraceptive, is used to prevent pregnancy by acting on the hormonal regulation of the menstrual cycle.
  • Contraception: provides reliable prevention of pregnancy in women of reproductive age.
  • Family planning: enables planned spacing of pregnancies for women seeking to control childbearing.
  • Menstrual cycle regulation: helps achieve more predictable menstrual periods and may reduce cycle‑related symptoms.
  • Acne management: may improve mild acne associated with hormonal fluctuations.

How It Works

  • Drospirenone is a synthetic progestogen with anti‑mineralocorticoid activity, while ethinylestradiol is a synthetic estrogen. Together they bind to progesterone and estrogen receptors, suppressing the hypothalamic‑pituitary‑ovarian axis, which inhibits the mid‑cycle surge of luteinizing hormone and follicle‑stimulating hormone, preventing ovulation. The combination also induces cervical mucus changes that are hostile to sperm and alters the endometrium, reducing the likelihood of implantation.

Side Effects

Katul may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial pain.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Spotting: irregular vaginal bleeding between periods.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins or lungs.
  • Stroke: cerebrovascular accident, especially in high‑risk individuals.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Liver dysfunction: jaundice or abnormal liver enzymes.

Precautions & Warnings

Before prescribing Katul, clinicians should evaluate individual risk factors and contraindications.

  • Contraindication: do not use in women with known thromboembolic disorders or estrogen‑dependent tumors.
  • Smoking: avoid if over 35 years and a smoker, as risk of cardiovascular events increases.
  • Medication review: assess concomitant use of enzyme‑inducing drugs that may reduce efficacy.
  • Blood pressure monitoring: check regularly, especially in patients with hypertension.
  • Pregnancy: contraindicated; discontinue immediately if pregnancy occurs.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Katul can interact with several medicines, altering its effectiveness or increasing side‑effect risk.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): markedly reduce hormone levels, compromising contraceptive effect.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine) at high doses: may increase risk of hormonal side effects.
  • Antifungal azoles (e.g., ketoconazole): may increase hormone concentrations, raising side‑effect risk.

Moderate Interactions (Monitor Closely)

  • Antibiotics (e.g., tetracycline): may slightly decrease effectiveness; advise backup contraception.
  • Herbal supplements (e.g., St John’s wort): may lower plasma levels of hormones.
  • Diuretics (e.g., spironolactone): may enhance anti‑mineralocorticoid effect, leading to electrolyte changes.

Frequently Asked Questions

Katul is a combined oral contraceptive containing drospirenone and ethinylestradiol, prescribed to prevent pregnancy in women of reproductive age. It works by inhibiting ovulation and creating cervical mucus conditions unfavorable to sperm, providing a reliable method of hormonal birth control.

The drospirenone component acts as a progestogen with anti‑mineralocorticoid activity, while ethinylestradiol is a synthetic estrogen. Together they bind to progesterone and estrogen receptors, suppress the hypothalamic‑pituitary‑ovarian axis, prevent the LH surge, and thus block ovulation. They also thicken cervical mucus and alter the endometrium to reduce fertilization and implantation.

The dosing regimen for Katul is determined by the prescribing healthcare professional. Typically, it is taken as one tablet daily at the same time each day, following the specific pack instructions provided by the prescriber. Patients should not alter the dose or frequency without medical guidance.

Katul is contraindicated during pregnancy; it must be discontinued if pregnancy is confirmed. For breastfeeding women, combined oral contraceptives are generally not recommended during the early postpartum period because estrogen may affect milk production. Consultation with a healthcare provider is essential to choose an appropriate contraceptive method.

To place an order, visit the product page on gnhindia.com, submit an enquiry with the required quantity, and provide institutional or trade credentials. GNH India works with hospitals, pharmacies, and procurement teams worldwide, then replies with pricing, availability, shipping details, and any necessary import documentation.

Katul contains drospirenone, which has anti‑mineralocorticoid properties that may reduce water retention compared with some other progestins. Its efficacy in preventing pregnancy is comparable to other combined oral contraceptives, while the side‑effect profile may differ, with a potentially lower incidence of weight gain but a similar risk of thromboembolic events. Choice depends on individual risk factors and physician assessment.

Katul tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister pack to protect them from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Katul is taken orally, usually as one tablet each day, at the same time each day, without regard to meals. The typical pack contains a series of active tablets followed by placebo tablets to maintain a regular dosing schedule, but patients should follow the specific instructions given by their prescriber.

The most serious risks include venous thromboembolism, stroke, and myocardial infarction, particularly in women with pre‑existing risk factors such as smoking, hypertension, or a history of clotting disorders. Severe allergic reactions and liver dysfunction are also rare but critical concerns. Prompt medical attention is required if symptoms such as sudden chest pain, severe headache, or jaundice occur.

Katul should not be used by women who are pregnant, have a known history of thromboembolic disease, estrogen‑dependent tumors, uncontrolled hypertension, or severe liver disease. It is also contraindicated in smokers over 35 years of age and in individuals with known hypersensitivity to drospirenone, ethinylestradiol, or any tablet excipients. A healthcare professional must evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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