Product image of Kayexalate Calcium (Calcium Polystyrene Sulfonate) supplied by GNH India

Kayexalate Calcium

Active Ingredient:
Calcium Polystyrene Sulfonate
Origin:
EU

Kayexalate Calcium (Calcium Polystyrene Sulfonate)

Calcium Polystyrene Sulfonate, the active ingredient in Kayexalate Calcium, is a cation exchange resin presented as a powder for oral and rectal use. It binds potassium in the gastrointestinal tract and is used to treat hyperkalemia in patients with elevated serum potassium levels.

GNH India supplies Kayexalate Calcium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Belgium

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Indications & Clinical Uses

Kayexalate Calcium is a potassium‑binding resin used in the management of conditions characterized by excess potassium.

  • Hyperkalemia (acute): lowers serum potassium to safe levels.
  • Hyperkalemia (chronic): maintains long‑term potassium control.
  • Hyperkalemia in renal failure: provides potassium removal when kidney function is impaired.

How It Works

  • Calcium Polystyrene Sulfonate is a cation exchange resin that remains in the gastrointestinal lumen. Its sulfonate groups exchange calcium ions for potassium ions in the gut, trapping potassium within the resin matrix. The bound potassium is then eliminated in the feces, resulting in a net reduction of serum potassium concentrations.

Side Effects

Kayexalate Calcium may cause gastrointestinal and electrolyte‑related adverse reactions.

Common Side Effects

  • Nausea: mild to moderate discomfort after ingestion.
  • Constipation: reduced bowel movements, may require laxatives.
  • Abdominal discomfort: cramping or pain in the stomach area.
  • Vomiting: occasional expulsion of stomach contents.
  • Diarrhea: loose stools in some patients.
  • Taste alteration: metallic or unpleasant taste.

Serious or Rare Side Effects

  • Intestinal necrosis: severe bowel tissue damage, rare but serious.
  • Severe electrolyte disturbances: marked hypocalcemia or hypokalemia.
  • Bowel obstruction: blockage due to resin accumulation.
  • Gastrointestinal bleeding: rare hemorrhage in the GI tract.

Precautions & Warnings

When prescribing Kayexalate Calcium, clinicians should consider several safety measures.

  • Monitor serum potassium: check levels regularly to avoid over‑correction.
  • Assess renal function: reduced clearance may increase risk of hyperkalemia.
  • Review concomitant potassium‑sparing agents: avoid additive potassium load.
  • Caution in patients with bowel disorders: risk of obstruction or necrosis.
  • Avoid in severe hypercalcemia: calcium exchange may worsen calcium excess.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Kayexalate Calcium can interact with other medicines that affect potassium balance or gastrointestinal absorption.

Major Interactions (Avoid)

  • Oral potassium supplements: may negate the resin's effect.
  • ACE inhibitors or ARBs: increase risk of severe hypokalemia.
  • Potassium‑sparing diuretics (e.g., spironolactone): additive potassium elevation.

Moderate Interactions (Monitor Closely)

  • Digoxin: hypokalemia can heighten digoxin toxicity.
  • Insulin therapy: rapid potassium shifts may cause hypoglycemia.
  • Beta‑blockers: altered response to potassium changes.

Frequently Asked Questions

Kayexalate Calcium is used to treat hyperkalemia, a condition where blood potassium levels are dangerously high. By binding potassium in the gastrointestinal tract, it helps lower serum potassium to safer concentrations in patients with acute or chronic potassium overload.

Calcium Polystyrene Sulfonate is a cation exchange resin that stays within the gut. Its sulfonate groups exchange calcium ions for potassium ions, trapping potassium in the resin. The bound potassium is then eliminated in the feces, reducing the amount of potassium absorbed into the bloodstream.

The dosage of Kayexalate Calcium is individualized by the prescribing clinician based on the severity of hyperkalemia, renal function, and other patient‑specific factors. The prescriber determines the appropriate amount, frequency, and route of administration.

Safety data for Kayexalate Calcium in pregnancy and lactation are limited, and the product’s pregnancy category is unknown. Clinicians should weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kayexalate Calcium uses calcium as the exchange ion, whereas sodium polystyrene sulfonate exchanges sodium for potassium. Calcium exchange may be preferred in patients where sodium load is a concern, but both agents share similar efficacy in lowering serum potassium and have comparable safety profiles.

Store Kayexalate Calcium at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture, and avoid exposure to extreme heat or direct sunlight to maintain its stability and effectiveness.

Kayexalate Calcium can be given orally as a suspension mixed with water or juice, or administered rectally as an enema. The exact method, volume, and frequency are determined by the prescriber according to the patient’s clinical condition.

The most serious risks include intestinal necrosis, severe electrolyte disturbances such as hypokalemia or hypocalcemia, and bowel obstruction. Patients should be monitored closely for abdominal pain, signs of bleeding, or abrupt changes in electrolyte levels.

Kayexalate Calcium should be avoided in patients with known hypersensitivity to calcium polystyrene sulfonate, severe hypercalcemia, active bowel obstruction, or those who cannot tolerate oral or rectal administration. Clinicians should also exercise caution in individuals with compromised gastrointestinal integrity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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