Product image of Kayexalate Sodium (Sodium Polystyrene Sulfonate) supplied by GNH India

Kayexalate Sodium

Active Ingredient:
Sodium Polystyrene Sulfonate
Origin:
EU

Kayexalate Sodium (Sodium Polystyrene Sulfonate)

Sodium Polystyrene Sulfonate, the active ingredient in Kayexalate Sodium, is an ion‑exchange resin presented as an oral or rectal preparation for oral and rectal use. It is employed to lower elevated serum potassium levels in patients with hyperkalemia, particularly in those with renal impairment or receiving potassium‑sparing therapies.

GNH India supplies Kayexalate Sodium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies, clinics and other healthcare facilities worldwide.

Manufacturer / TM Owner

Sanofi Belgium

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Indications & Clinical Uses

Kayexalate Sodium is used to manage conditions involving excess potassium in the bloodstream.

  • Hyperkalemia: reduces serum potassium concentrations to safer levels.
  • Acute potassium overload: provides rapid potassium removal in emergency settings.
  • Chronic renal failure‑related hyperkalemia: assists long‑term potassium control when dietary measures are insufficient.

How It Works

  • Sodium Polystyrene Sulfonate acts as an ion‑exchange resin that binds potassium ions in the gastrointestinal tract in exchange for sodium ions. The bound potassium is then eliminated in the feces, leading to a net reduction of serum potassium levels without systemic absorption of the resin itself.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Constipation: reduced bowel movements.
  • Abdominal discomfort: cramping or pain.
  • Diarrhea: loose stools.
  • Taste alteration: metallic or salty taste.
  • Electrolyte imbalance: mild sodium increase.

Serious or Rare Side Effects

  • Intestinal necrosis: severe bowel tissue damage.
  • Colonic perforation: rare but life‑threatening.
  • Severe hypernatremia: excessive sodium accumulation.
  • Allergic reactions: rash, itching, swelling.
  • Metabolic acidosis: abnormal blood pH.
  • Severe dehydration: due to fluid loss.

Precautions & Warnings

Kayexalate Sodium should be used with caution in specific clinical situations.

  • Renal impairment: monitor potassium and sodium levels closely.
  • Cardiovascular disease: watch for fluid shifts and electrolyte changes.
  • Gastrointestinal disorders: avoid in patients with active bowel obstruction or recent GI surgery.
  • Concomitant potassium‑sparing drugs: adjust dosing to prevent additive effects.
  • Pregnancy and lactation: use only if clearly needed, as safety data are limited.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Kayexalate Sodium may interact with several medications, requiring careful management.

Major Interactions (Avoid)

  • Sodium polystyrene sulfonate with sorbitol: increased risk of intestinal necrosis.
  • ACE inhibitors or ARBs: may potentiate hyperkalemia if resin is ineffective.
  • Digoxin: altered absorption may affect drug levels.

Moderate Interactions (Monitor Closely)

  • Lithium: resin may increase lithium concentrations.
  • Antacids containing aluminum or magnesium: reduced resin efficacy.
  • Oral potassium supplements: may diminish potassium‑lowering effect.

Frequently Asked Questions

Kayexalate Sodium, containing sodium polystyrene sulfonate, is prescribed to lower elevated serum potassium levels in patients with hyperkalemia, including those with renal impairment or on potassium‑sparing therapies.

The resin exchanges sodium ions for potassium ions within the gastrointestinal tract. Bound potassium is then eliminated in the feces, resulting in a net decrease of potassium in the bloodstream.

The appropriate dose is determined by the prescribing clinician based on the patient’s potassium level, renal function, and overall clinical condition. Dosing regimens are individualized and not standardized.

Safety data for sodium polystyrene sulfonate in pregnancy and lactation are limited. It should only be used when clearly needed and after a risk‑benefit assessment by the healthcare provider.

Submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Kayexalate Sodium is an ion‑exchange resin, whereas alternatives like patiromer or sodium zirconium cyclosilicate are non‑resin binders with different onset times and side‑effect profiles. Choice depends on patient tolerance, comorbidities and clinician preference.

Store at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

The resin can be given orally as a suspension mixed with water or other suitable liquid, or rectally as an enema. Administration instructions, including mixing ratios and timing, are provided by the prescribing clinician.

Serious risks include intestinal necrosis, colonic perforation, severe hypernatremia, and rare allergic reactions. Prompt medical attention is required if severe abdominal pain, bleeding, or signs of infection occur.

Patients with active bowel obstruction, recent gastrointestinal surgery, known hypersensitivity to the resin, or those taking sorbitol‑containing formulations should avoid Kayexalate Sodium unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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