Product image of Keflex (Cefalexin) supplied by GNH India

Keflex

Active Ingredient:
Cefalexin
Origin:
EU

Keflex (Cefalexin)

Cephalexin, the active ingredient in Keflex, is a first‑generation cephalosporin presented as an oral tablet for systemic use. It treats bacterial infections of the skin, respiratory tract, urinary tract and bone in adults and children as prescribed.

GNH India supplies Keflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eurocept International Bv

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Indications & Clinical Uses

Keflex (cephalexin) is a first‑generation cephalosporin used to treat infections caused by susceptible bacteria.

  • Skin infections: resolves cellulitis, impetigo and other bacterial skin conditions.
  • Respiratory tract infections: treats acute bacterial sinusitis, pharyngitis and bronchitis.
  • Urinary tract infections: eradicates uncomplicated cystitis caused by susceptible organisms.
  • Bone and joint infections: assists in managing osteomyelitis and septic arthritis when indicated.

How It Works

  • Cephalexin inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, which prevents the cross‑linking of peptidoglycan strands. This disruption weakens the cell wall, leading to osmotic instability and bacterial lysis, primarily affecting Gram‑positive organisms and some Gram‑negative strains.

Side Effects

Adverse reactions to cephalexin can range from mild to severe and may require medical attention.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema or itching.
  • Headache: transient tension‑type headache.
  • Vaginal candidiasis: yeast overgrowth in some patients.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with airway compromise.
  • Stevens‑Johnson syndrome: rare but life‑threatening skin eruption.
  • Clostridioides difficile colitis: severe diarrhea due to bacterial overgrowth.
  • Hemolytic anemia: destruction of red blood cells.
  • Liver enzyme elevation: potential hepatic involvement.
  • Severe neutropenia: marked reduction in white blood cells.

Precautions & Warnings

Before prescribing cephalexin, clinicians should consider patient‑specific factors and potential risks.

  • Allergy assessment: avoid if known hypersensitivity to cephalosporins or penicillins.
  • Renal function: adjust dose in patients with impaired kidney function.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit evaluation.
  • Drug interactions: review concomitant medications for possible interactions.
  • Storage: Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Cephalexin may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Probenecid: reduces renal excretion, increasing cephalexin levels.
  • Warfarin: may enhance anticoagulant effect, raising bleeding risk.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in hormonal efficacy.
  • Metformin: may increase plasma concentration, monitor renal function.
  • Aminoglycosides: combined nephrotoxicity potential.
  • Antacids containing aluminum or magnesium: may decrease absorption if taken simultaneously.

Frequently Asked Questions

Keflex (cephalexin) is prescribed for bacterial skin infections such as cellulitis and impetigo, respiratory tract infections like sinusitis and bronchitis, uncomplicated urinary tract infections, and certain bone or joint infections when the causative bacteria are susceptible.

Cephalexin belongs to the cephalosporin class and works by binding to penicillin‑binding proteins on bacterial cell walls. This inhibits the final step of peptidoglycan synthesis, weakening the wall and causing bacterial lysis and death.

The dosage of Keflex is individualized by the prescribing clinician based on the type and severity of infection, patient age, weight, and renal function. Patients should follow the exact regimen provided by their healthcare professional.

Cephalexin is classified as a pregnancy category B drug in many regions, indicating no evidence of risk in animal studies but limited human data. It may be used during pregnancy or lactation only when clearly needed, after a risk‑benefit assessment by the prescriber.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both are beta‑lactam antibiotics, but Keflex (a cephalosporin) has a broader spectrum against Gram‑positive organisms and some Gram‑negative bacteria, whereas amoxicillin is a penicillin derivative primarily targeting Gram‑positive and certain Gram‑negative species. Choice depends on bacterial susceptibility and patient tolerance.

Keflex tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Do not store in humid environments such as bathrooms, and keep out of reach of children.

Keflex is taken orally, usually with a full glass of water. It can be taken with or without food, but if gastrointestinal upset occurs, it may be helpful to take it with meals. The tablet should be swallowed whole and not crushed or chewed unless instructed otherwise.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, Clostridioides difficile‑associated colitis, and hematologic abnormalities like hemolytic anemia or neutropenia. Patients should seek immediate medical attention if they experience rash, fever, persistent diarrhea, or signs of an allergic reaction.

Individuals with a known hypersensitivity to cephalexin, other cephalosporins, or penicillins should avoid Keflex. Patients with severe renal impairment may require dose adjustment, and those with a history of severe allergic reactions should discuss alternatives with their clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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