Product image of Keflex (Cefalexin) supplied by GNH India

Keflex

Active Ingredient:
Cefalexin
Origin:
EU

Keflex (Cefalexin)

Cefalexin, the active ingredient in Keflex, is a first‑generation cephalosporin presented as an oral tablet for oral use. It treats bacterial infections of the skin, urinary tract, respiratory system and bone in adult and pediatric patients as prescribed by a healthcare professional. It is indicated for a range of infections and is commonly used in outpatient and inpatient settings under medical supervision.

GNH India supplies Keflex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory compliance across all markets.

Manufacturer / TM Owner

Flynn Pharma Ltd

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Indications & Clinical Uses

Cefalexin (Keflex) is a first‑generation cephalosporin antibiotic that targets bacterial infections of various organ systems.

  • Skin and soft tissue infections: effective in treating bacterial infections of the skin and underlying tissues.
  • Urinary tract infections: used to eradicate common uropathogens causing cystitis and pyelonephritis.
  • Respiratory tract infections: indicated for bacterial sinusitis, bronchitis and community‑acquired pneumonia.
  • Bone and joint infections: employed in the management of osteomyelitis and septic arthritis caused by susceptible organisms.

How It Works

  • Cefalexin binds to penicillin‑binding proteins on the bacterial cell wall, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption weakens the cell wall, leading to osmotic instability and bacterial lysis, thereby eliminating susceptible Gram‑positive and some Gram‑negative organisms.

Side Effects

Cefalexin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Diarrhea: mild to moderate loose stools.
  • Nausea: feeling of stomach upset.
  • Vomiting: expulsion of stomach contents.
  • Rash: mild skin erythema or itching.
  • Headache: transient cranial discomfort.
  • Abdominal pain: crampy discomfort in the stomach area.

Serious or Rare Side Effects

  • Anaphylaxis: severe, life‑threatening allergic reaction.
  • Clostridioides difficile‑associated colitis: severe diarrhea with abdominal pain.
  • Stevens‑Johnson syndrome: extensive skin blistering and mucosal involvement.
  • Blood dyscrasias: neutropenia, thrombocytopenia, or hemolytic anemia.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Renal impairment: reduced kidney function or interstitial nephritis.

Precautions & Warnings

When prescribing or dispensing Cefalexin, consider the following precautions to ensure safe use.

  • Renal function assessment: adjust dose in patients with impaired kidney function.
  • Allergy history: avoid in patients with known hypersensitivity to cephalosporins or penicillins.
  • Superinfection risk: monitor for secondary infections such as Clostridioides difficile colitis.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Cefalexin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Probenecid: may increase cefalexin plasma concentrations, raising toxicity risk.
  • Warfarin: can enhance anticoagulant effect, increasing bleeding tendency.
  • Live bacterial vaccines: may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in hormonal effectiveness.
  • Antacids containing aluminum or magnesium: may decrease cefalexin absorption.
  • Diuretics: potential for increased nephrotoxicity in susceptible patients.

Frequently Asked Questions

Keflex (cefalexin) is an oral first‑generation cephalosporin antibiotic prescribed to treat bacterial infections of the skin, urinary tract, respiratory system and bone. It is used when the infecting organism is known or suspected to be susceptible, and the choice is guided by the prescriber based on infection severity, patient factors and local resistance patterns.

Cefalexin works by binding to penicillin‑binding proteins on the bacterial cell wall, blocking the cross‑linking of peptidoglycan strands. This inhibition weakens the cell wall, causing osmotic instability and ultimately bacterial cell lysis, which eliminates susceptible Gram‑positive and some Gram‑negative bacteria.

The dosage of Keflex is determined by the prescribing clinician based on the type and severity of infection, patient age, weight, renal function and other clinical considerations. No standard dose is provided here; the prescriber will specify the appropriate regimen for each individual case.

Safety data for cefalexin in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant. The prescriber should evaluate the clinical situation and discuss any concerns with the patient.

To order Keflex, submit an enquiry on the product page at gnhindia.com, providing the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide and will request verification of trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details and any necessary import documentation.

Keflex (cefalexin) is a cephalosporin, whereas amoxicillin is a penicillin‑type antibiotic. Both cover many common Gram‑positive organisms, but cefalexin often retains activity against some penicillin‑resistant strains and has a lower risk of certain beta‑lactamase‑mediated resistance. Choice between them depends on susceptibility patterns, patient allergy history and infection site.

Keflex tablets should be stored at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid environments such as bathrooms.

Keflex is administered orally as a tablet that should be swallowed whole with a full glass of water. It may be taken with or without food, although taking it with food can reduce gastrointestinal upset in some patients.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, Stevens‑Johnson syndrome, and blood dyscrasias like neutropenia or hemolytic anemia. Patients should seek immediate medical attention if they develop rash, fever, persistent diarrhea, or signs of an allergic reaction.

Keflex should not be used by individuals with a known hypersensitivity to cefalexin, other cephalosporins, or penicillins. It is also contraindicated in patients with severe renal impairment unless dose adjustments are made, and it should be avoided in those with a history of severe drug‑induced skin reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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