Product image of Keforal (Cefalexin) supplied by GNH India

Keforal

Active Ingredient:
Cefalexin
Origin:
EU

Keforal (Cefalexin)

Cefalexin, the active ingredient in Keforal, is a first‑generation cephalosporin presented as a tablet for oral use. It treats bacterial infections of the skin, respiratory tract, urinary system, and bone and joint in both adults and children as prescribed.

GNH India supplies Keforal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eurocept International Bv

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Indications & Clinical Uses

Keforal, a cephalosporin antibiotic, is employed to combat bacterial infections in several organ systems.

  • Skin and soft‑tissue infections: eradicates susceptible pathogens and promotes healing of cellulitis and impetigo.
  • Respiratory tract infections: treats acute bronchitis, sinusitis, and community‑acquired pneumonia caused by susceptible bacteria.
  • Urinary tract infections: eliminates causative organisms in cystitis and uncomplicated pyelonephritis.
  • Bone and joint infections: assists in resolving osteomyelitis and septic arthritis when appropriate.

How It Works

  • Cefalexin inhibits bacterial cell wall synthesis by binding to penicillin‑binding proteins, which disrupts the cross‑linking of peptidoglycan strands. This interference leads to weakened cell walls, osmotic instability, and ultimately bacterial cell lysis, effectively eliminating susceptible Gram‑positive and some Gram‑negative organisms.

Side Effects

Adverse reactions may occur with cefalexin therapy.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, occasionally watery.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema or itching.
  • Headache: transient mild headache.
  • Vomiting: occasional emesis.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with airway compromise.
  • Stevens‑Johnson syndrome: rare severe skin and mucosal lesions.
  • Clostridioides difficile‑associated diarrhea: severe colitis.
  • Hematologic abnormalities: neutropenia or thrombocytopenia.
  • Hepatic dysfunction: elevated liver enzymes.
  • Renal impairment: acute kidney injury in susceptible patients.

Precautions & Warnings

Before prescribing Keforal, consider the following precautions.

  • Assess renal function: adjust dosage in patients with renal impairment.
  • Monitor for allergic reactions: discontinue immediately if severe hypersensitivity occurs.
  • Use with caution in patients with a history of colitis: risk of C. difficile infection.
  • Avoid in individuals with known hypersensitivity to cephalosporins or penicillins.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Cefalexin may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Probenecid: can increase cefalexin plasma concentrations, raising toxicity risk.
  • Live bacterial vaccines: may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Oral contraceptives: possible reduction in contraceptive effectiveness.
  • Antacids containing aluminum or magnesium: may decrease cefalexin absorption if taken simultaneously.

Frequently Asked Questions

Keforal contains cefalexin, a first‑generation cephalosporin antibiotic indicated for treating bacterial skin and soft‑tissue infections, respiratory tract infections such as bronchitis and sinusitis, urinary tract infections including cystitis, and bone or joint infections like osteomyelitis, when the causative organisms are susceptible.

Cefalexin works by binding to bacterial penicillin‑binding proteins, inhibiting the synthesis of the peptidoglycan layer of the cell wall. This disruption weakens the wall, leading to osmotic lysis and death of susceptible Gram‑positive and some Gram‑negative bacteria.

The dosage of Keforal is determined by the prescribing healthcare professional based on the type and severity of infection, patient age, weight, and renal function. Patients should follow the exact regimen provided by their prescriber and not adjust the dose on their own.

Safety data for cefalexin during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Pregnant or nursing patients should discuss use with their healthcare provider.

To order Keforal, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and necessary import documentation.

Keforal (cef alexin) is a cephalosporin, offering a broader spectrum against certain Gram‑positive organisms compared with penicillins like amoxicillin, and it is generally more resistant to beta‑lactamase degradation. However, amoxicillin may be preferred for some beta‑lactamase‑producing strains, and choice depends on susceptibility patterns and clinical context.

Keforal tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Keforal is administered orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal upset. Patients should swallow tablets whole and not crush or chew them unless instructed otherwise.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they develop rash, fever, persistent diarrhea, or signs of an allergic reaction.

Keforal should not be used by individuals with a known hypersensitivity to cefalexin, other cephalosporins, or penicillins. It is also contraindicated in patients who have experienced severe allergic reactions to beta‑lactam antibiotics. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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