Product image of Kefzero (Cefuroxime Axetil) supplied by GNH India

Kefzero

Active Ingredient:
Cefuroxime Axetil
Origin:
EU

Kefzero (Cefuroxime Axetil)

Cefuroxime Axetil, the active ingredient in Kefzero, is a second‑generation cephalosporin presented as an oral tablet for oral use. It treats bacterial infections such as respiratory, urinary, and skin infections in adults and children as directed by a healthcare professional.

GNH India supplies Kefzero as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and health‑care institutions worldwide through regulated distribution channels, ensuring product quality and compliance with local regulations. Our network enables reliable access to essential antibiotics across diverse markets.

Manufacturer / TM Owner

Day Zero Ehf

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Indications & Clinical Uses

Cefuroxime Axetil is a second‑generation cephalosporin used to treat bacterial infections in various organ systems.

  • Respiratory tract infections: effective against community‑acquired pneumonia and acute bronchitis.
  • Urinary tract infections: active against common uropathogens causing cystitis and pyelonephritis.
  • Skin and soft tissue infections: treats cellulitis, abscesses and wound infections.
  • Sinusitis: reduces bacterial load in acute bacterial sinusitis.
  • Otitis media: clears infection in middle‑ear inflammation.

How It Works

  • Cefuroxime Axetil is hydrolyzed to cefuroxime, which binds to penicillin‑binding proteins on bacterial cell walls, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption weakens the cell wall, leading to osmotic instability and bacterial lysis, particularly in susceptible Gram‑positive and Gram‑negative organisms.

Side Effects

Cefuroxime Axetil may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Abdominal pain: cramping or discomfort.
  • Headache: transient mild headache.
  • Rash: erythematous skin eruption.
  • Vomiting: occasional emesis.

Serious or Rare Side Effects

  • Clostridioides difficile colitis: severe diarrhea with possible colitis.
  • Anaphylaxis: life‑threatening allergic reaction.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane involvement.
  • Hematologic abnormalities: neutropenia or thrombocytopenia.
  • Hepatic enzyme elevation: abnormal liver function tests.
  • Renal impairment: worsening kidney function in susceptible patients.

Precautions & Warnings

When prescribing Cefuroxime Axetil, consider the following precautions to ensure safe use.

  • Renal function: adjust dose in patients with impaired renal clearance.
  • Allergy history: avoid in individuals with known hypersensitivity to cephalosporins or penicillins.
  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus.
  • Anticoagulants: monitor INR or PT when co‑administered with warfarin.
  • Pediatric dosing: calculate dose based on body weight and age.
  • Store at ambient temperature: keep in the original container, protect from moisture and excessive heat.

Avoid Interactions

Cefuroxime Axetil can interact with other medicines; monitor the following interactions.

Major Interactions (Avoid)

  • Probenecid: may increase serum cefuroxime concentrations, raising toxicity risk.
  • Warfarin: can potentiate anticoagulant effect, requiring close INR monitoring.
  • Live vaccines: concurrent use may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Diuretics: may affect renal excretion, necessitating dose adjustment.
  • Aminoglycosides: combined nephrotoxic potential warrants renal function monitoring.
  • Oral contraceptives: cefuroxime may reduce hormonal efficacy, advise additional contraceptive measures.

Frequently Asked Questions

Kefzero contains cefuroxime axetil, a broad‑spectrum second‑generation cephalosporin indicated for treating bacterial infections such as community‑acquired pneumonia, acute bronchitis, urinary tract infections, skin and soft‑tissue infections, sinusitis and otitis media, as prescribed by a qualified healthcare professional.

Cefuroxime axetil is a pro‑drug that is converted in the body to cefuroxime. The active molecule binds to penicillin‑binding proteins on bacterial cell walls, blocking the transpeptidation step of peptidoglycan synthesis, which weakens the wall and leads to bacterial cell lysis.

The dose of Kefzero is individualized by the prescribing clinician based on the type and severity of infection, patient age, weight, renal function and any concomitant medications. No fixed regimen is provided here; the prescriber sets the appropriate dosage and duration.

Safety data for cefuroxime axetil in pregnancy are limited. It should be used only if the potential benefit outweighs any possible risk to the fetus. Limited information exists for lactation; a decision should be made by the healthcare provider after evaluating maternal and infant considerations.

To order Kefzero, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation cephalosporins, cefuroxime axetil offers broader coverage against Gram‑negative organisms while retaining activity against many Gram‑positive bacteria. It is often preferred over amoxicillin for resistant strains and provides oral convenience versus parenteral third‑generation agents, though susceptibility testing guides optimal selection.

Kefzero tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in humid or excessively hot environments.

Kefzero is taken orally, usually with a full glass of water. It may be taken with or without food, but consistency with meals can help reduce gastrointestinal upset. The exact timing and frequency are determined by the prescriber based on the infection being treated.

Serious risks include severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and hematologic abnormalities like neutropenia or thrombocytopenia. Prompt medical attention is required if any signs of these conditions appear.

Patients with a documented hypersensitivity to cefuroxime, other cephalosporins, or penicillins should avoid Kefzero. Caution is also advised for individuals with severe renal impairment, a history of severe allergic reactions, or those currently receiving live vaccines, unless directed otherwise by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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