Kelis (Ketoprofen Lysine)

Kelis, a ketoprofen lysine NSAID, acts on inflammatory pathways to alleviate pain and swelling.

• Mild to moderate pain: Provides analgesic relief for headaches, dental pain, postoperative discomfort, and other acute pain states.
• Rheumatoid arthritis: Reduces joint inflammation and pain, improving functional ability.
• Osteoarthritis: Alleviates chronic joint pain and stiffness associated with degenerative joint disease.
• Musculoskeletal pain: Decreases inflammation and discomfort in sprains, strains, and back pain.

• Ketoprofen lysine exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting reduction in prostaglandin synthesis diminishes inflammation, pain, and fever at the site of tissue injury.

Kelis may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

• Gastrointestinal discomfort such as nausea, dyspepsia, or abdominal pain.
• Headache or dizziness.
• Mild skin reactions like rash or pruritus.
• Elevated blood pressure.
• Fluid retention leading to peripheral edema.

Serious or Rare Side Effects

• Peptic ulcer disease or gastrointestinal bleeding.
• Severe hepatic or renal impairment.
• Anaphylactic reactions or severe skin disorders (e.g., Stevens‑Johnson syndrome).
• Cardiovascular events such as myocardial infarction or stroke.
• Hematologic abnormalities including thrombocytopenia.

Before using Kelis, consider the following safety measures.

• Cardiovascular risk: Avoid in patients with a history of heart disease or uncontrolled hypertension.
• Gastrointestinal safety: Use cautiously in individuals with prior ulcers or gastrointestinal bleeding.
• Renal function: Monitor kidney function in patients with existing renal impairment.
• Hepatic health: Assess liver enzymes regularly for those with liver disease.
• Store at ambient temperature: Keep below 25 °C, in the original packaging, protected from moisture and direct sunlight.

Kelis can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): Increased risk of serious bleeding.
• Other NSAIDs or corticosteroids: Heightened gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): Elevated bleeding risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or diuretics: May reduce renal function.
• Lithium: Potential for increased lithium levels.
• Methotrexate: Possible accumulation leading to toxicity.