Product image of Kelzy (Dienogest, Ethinylestradiol | Lactose) supplied by GNH India

Kelzy

Active Ingredient:
Dienogest, Ethinylestradiol | Lactose
Origin:
EU

Kelzy (Dienogest, Ethinylestradiol | Lactose)

Dienogest/Ethinylestradiol, the active ingredients in Kelzy, are a combined oral contraceptive presented as a tablet for oral use. The formulation provides hormonal birth control by inhibiting ovulation and creating conditions unfavorable for fertilization and implantation. It is prescribed for women of reproductive age seeking reliable contraception.

GNH India supplies Kelzy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures consistent quality and regulatory compliance across diverse markets.

Manufacturer / TM Owner

Exeltis Germany Gmbh

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Indications & Clinical Uses

  • Kelzy, a combined oral contraceptive, acts on the hormonal regulation pathway to prevent pregnancy.
  • Contraception (prevention of pregnancy): provides reliable hormonal birth control by suppressing ovulation and altering cervical mucus.
  • Menstrual cycle regulation: helps achieve more predictable menstrual bleeding patterns in women using hormonal contraception.
  • Acne management: reduces androgen‑driven skin lesions through hormonal modulation in some women.

How It Works

  • Kelzy combines the progestogenic agent dienogest with the estrogen ethinylestradiol. Dienogest binds to progesterone receptors, suppressing the mid‑cycle surge of luteinizing hormone (LH) and follicle‑stimulating hormone (FSH), thereby preventing ovulation. Ethinylestradiol stabilizes the endometrial lining and enhances negative feedback on the hypothalamic‑pituitary axis, further reducing LH/FSH release and inducing cervical mucus changes that impede sperm penetration.

Side Effects

Kelzy may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Weight gain
  • Mood changes
  • Irregular bleeding

Serious or Rare Side Effects

  • Deep vein thrombosis
  • Pulmonary embolism
  • Stroke
  • Myocardial infarction
  • Severe allergic reaction (anaphylaxis)
  • Hepatotoxicity

Precautions & Warnings

  • Before prescribing Kelzy, clinicians should consider several safety measures.
  • Medical evaluation: obtain a thorough medical history to identify contraindications such as thromboembolic disorders.
  • Smoking status: advise against use in women over 35 who smoke heavily.
  • Concurrent medications: review use of enzyme‑inducing drugs that may reduce efficacy.
  • Pregnancy testing: confirm non‑pregnant status before initiating therapy.
  • Breastfeeding: assess risks and benefits, as hormonal exposure may affect lactation.
  • Store at ambient temperature: keep tablets in the original container, protect from moisture and heat.

Avoid Interactions

Kelzy can interact with other medicines, requiring careful assessment.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase risk of thrombosis.
  • Hepatic enzyme inducers (e.g., rifampin, carbamazepine): reduce contraceptive effectiveness.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): may increase plasma levels of ethinylestradiol.
  • Antiretrovirals (e.g., protease inhibitors): may alter hormone metabolism.
  • St. John’s wort: can diminish contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors): monitor blood pressure changes.
  • Diuretics: may affect electrolyte balance.
  • Anticonvulsants with moderate enzyme induction (e.g., phenobarbital): monitor for reduced efficacy.
  • Antibiotics (e.g., tetracycline): potential minor reduction in absorption.
  • Herbal supplements (e.g., ginseng): observe for any hormonal interaction.

Frequently Asked Questions

Kelzy is a combined oral contraceptive indicated for the prevention of pregnancy in women of reproductive age. By delivering a fixed dose of dienogest and ethinylestradiol, it provides reliable hormonal birth control through suppression of ovulation and alteration of cervical mucus.

Dienogest acts as a progestogen, binding to progesterone receptors and inhibiting the LH and FSH surge that triggers ovulation. Ethinylestradiol, an estrogen, reinforces negative feedback on the hypothalamic‑pituitary axis, stabilizes the endometrium, and thickens cervical mucus, together preventing fertilization and implantation.

The specific dosing regimen for Kelzy is determined by the prescribing healthcare professional. Typically, the product is taken once daily at the same time each day, but the exact number of tablets per pack and any missed‑dose instructions are set by the prescriber based on individual patient needs.

Kelzy is contraindicated during pregnancy because it is designed to prevent conception. If pregnancy occurs, the product should be discontinued. Regarding breastfeeding, clinicians should weigh the benefits against potential risks, as hormonal exposure may affect milk production and infant hormone balance; a healthcare provider should be consulted.

To order Kelzy, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details, and any necessary import documentation.

Kelzy contains dienogest, a progestogen with a favorable metabolic profile, combined with ethinylestradiol. Compared with older formulations that use levonorgestrel, dienogest may offer lower androgenic activity and a reduced impact on lipid metabolism, while maintaining comparable contraceptive efficacy and cycle control.

Kelzy tablets should be stored at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from excess moisture, direct sunlight, and heat. Keep the product out of reach of children and do not use tablets that appear discolored or damaged.

Kelzy is taken orally, usually as a single tablet each day, at the same time each day. The tablet is swallowed whole with water and can be taken with or without food. Consistency in timing helps maintain stable hormone levels and maximizes contraceptive effectiveness.

The most serious risks include thromboembolic events such as deep vein thrombosis, pulmonary embolism, stroke, and myocardial infarction. These events are more likely in women with pre‑existing clotting disorders, smokers over 35, or those taking interacting medications that increase clotting risk.

Kelzy should not be used by women with a history of thromboembolic disease, uncontrolled hypertension, known or suspected estrogen‑dependent tumors, active liver disease, or those who are pregnant. It is also contraindicated in smokers over 35 years of age and in individuals taking medications that severely reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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