Product image of Kelzyn (Dienogest, Ethinylestradiol | Lactose) supplied by GNH India

Kelzyn

Active Ingredient:
Dienogest, Ethinylestradiol | Lactose
Origin:
EU

Kelzyn (Dienogest, Ethinylestradiol | Lactose)

Dienogest, the active ingredient in Kelzyn, is a combined oral contraceptive presented as a tablet for oral use. Together with ethinylestradiol, it provides hormonal regulation that prevents pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus.

GNH India supplies Kelzyn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across markets, and meeting the needs of diverse healthcare providers. The product is manufactured under strict GMP standards and distributed to multiple regions.

Manufacturer / TM Owner

Exeltis Healthcare S.L

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Indications & Clinical Uses

Kelzyn, a combined oral contraceptive, acts on the hormonal regulation pathway to prevent pregnancy.

  • Contraception: prevents pregnancy by suppressing ovulation and altering cervical mucus.
  • Menstrual cycle regulation: helps achieve more regular menstrual cycles.
  • Dysmenorrhea management: reduces menstrual pain and cramps.

How It Works

  • Kelzyn combines ethinylestradiol, a synthetic estrogen, with dienogest, a progestogen. Ethinylestradiol binds to estrogen receptors, stabilizing the endometrial lining, while dienogest binds to progesterone receptors, inhibiting the mid‑cycle luteinizing hormone surge. The combined hormonal effect suppresses ovulation, thickens cervical mucus, and induces endometrial changes that prevent implantation.

Side Effects

Kelzyn may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset.
  • Headache: tension or migraine‑type pain.
  • Breast tenderness: swelling or discomfort.
  • Irregular bleeding: spotting or breakthrough bleeding.
  • Weight gain: mild increase in body weight.
  • Mood changes: irritability or emotional fluctuations.

Serious or Rare Side Effects

  • Deep vein thrombosis: blood clot formation in veins.
  • Pulmonary embolism: clot traveling to lungs.
  • Stroke: cerebrovascular accident.
  • Myocardial infarction: heart attack.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Liver dysfunction: jaundice or abnormal liver enzymes.

Precautions & Warnings

Before prescribing Kelzyn, consider the following precautions to ensure safe use.

  • Smoking: avoid use in women over 35 who smoke due to increased cardiovascular risk.
  • Cardiovascular disease: contraindicated in patients with history of thromboembolic disorders.
  • Hypertension: monitor blood pressure regularly.
  • Liver disease: use with caution in hepatic impairment.
  • Migraine with aura: avoid due to heightened stroke risk.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Kelzyn can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants: may reduce effectiveness of warfarin, increasing clot risk.
  • Enzyme inducers (e.g., rifampicin, carbamazepine): can lower hormone levels, reducing contraceptive reliability.
  • Certain antiretrovirals (e.g., protease inhibitors): may increase hormone concentrations, raising side‑effect risk.

Moderate Interactions (Monitor Closely)

  • Antifungals (e.g., ketoconazole): may increase plasma levels of ethinylestradiol.
  • Antidepressants (e.g., SSRIs): may affect bleeding patterns.
  • Herbal supplements (e.g., St. John’s wort): may modestly reduce contraceptive effectiveness.

Frequently Asked Questions

Kelzyn is a combined oral contraceptive containing dienogest and ethinylestradiol. It is prescribed to prevent pregnancy in women of reproductive age by inhibiting ovulation and modifying cervical mucus. It may also be used to regulate menstrual cycles and reduce menstrual pain under medical guidance.

Dienogest is a synthetic progestogen that binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge that triggers ovulation. It also thickens cervical mucus and induces endometrial changes, contributing to contraceptive efficacy when combined with ethinylestradiol.

The dosage of Kelzyn is determined by the prescribing healthcare professional. Typically, it is taken as one tablet daily at the same time each day, but the exact regimen, including any missed‑dose instructions, must follow the prescriber’s order.

Kelzyn is intended for use only when pregnancy is not desired; it should not be started during an existing pregnancy. Women who are breastfeeding should consult their physician, as hormonal contraceptives may affect milk production and infant exposure.

To order Kelzyn, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kelzyn contains dienogest, a progestogen with a lower androgenic profile, combined with ethinylestradiol, which may result in fewer acne‑related side effects compared with some older formulations that use levonorgestrel. Efficacy in preventing pregnancy is comparable across approved combined pills.

Kelzyn tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Keep them away from moisture, heat and direct sunlight to maintain potency throughout the shelf life.

Kelzyn is taken orally, usually one tablet each day, preferably at the same time each day. Swallow the tablet whole with water; do not split, crush or chew unless instructed by a healthcare professional.

The most serious risks include venous thromboembolism, pulmonary embolism, stroke, myocardial infarction and severe allergic reactions. These events are rare but require immediate medical attention if symptoms such as sudden chest pain, shortness of breath, severe headache or rash occur.

Kelzyn is contraindicated in women who are pregnant, have a history of thromboembolic disorders, uncontrolled hypertension, active liver disease, breast cancer, or who smoke cigarettes and are over 35 years of age. Consultation with a healthcare provider is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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