Product image of Kemadrin (Procyclidine Hydrochloride) supplied by GNH India

Kemadrin

Active Ingredient:
Procyclidine Hydrochloride
Origin:
EU

Kemadrin (Procyclidine Hydrochloride)

Procyclidine, the active ingredient in Kemadrin, is an anticholinergic (muscarinic antagonist) presented as a tablet for oral use. It treats Parkinson's disease symptoms such as tremor and rigidity, and drug‑induced extrapyramidal symptoms in adults.

GNH India supplies Kemadrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Procyclidine is used in the management of movement disorders that involve excessive cholinergic activity.

  • Parkinson's disease (tremor, rigidity): reduces motor symptoms and improves daily function.
  • Drug‑induced extrapyramidal symptoms: alleviates dystonia, akathisia and other drug‑related movement disorders.
  • Secondary Parkinsonian syndrome: helps control motor disturbances when Parkinsonism arises from other causes.

How It Works

  • Procyclidine acts as a competitive antagonist at muscarinic acetylcholine receptors in the basal ganglia. By blocking these receptors it lowers cholinergic activity, thereby restoring the normal dopamine‑acetylcholine balance that is disrupted in Parkinsonian states and drug‑induced extrapyramidal conditions.

Side Effects

Procyclidine may cause a range of anticholinergic‑related adverse reactions.

Common Side Effects

  • Dry mouth
  • Blurred vision
  • Constipation
  • Urinary retention
  • Dizziness
  • Nausea

Serious or Rare Side Effects

  • Confusion or hallucinations
  • Severe tachycardia
  • Allergic reactions such as rash or angioedema
  • Neuroleptic malignant syndrome (very rare)
  • Acute glaucoma exacerbation

Precautions & Warnings

When prescribing Procyclidine, consider the following safety measures.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • Elderly patients: monitor for increased anticholinergic burden and cognitive effects.
  • History of glaucoma: avoid or use with extreme caution.
  • Cardiac disease: watch for tachycardia or arrhythmias.
  • Pregnancy: safety unknown; avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Procyclidine can interact with several medication classes; awareness helps prevent additive effects.

Major Interactions (Avoid)

  • Antihistamines (e.g., diphenhydramine): additive anticholinergic effects.
  • Tricyclic antidepressants: increased anticholinergic load.
  • Antipsychotics (e.g., haloperidol): may worsen extrapyramidal symptoms.
  • Beta‑blockers: may mask tachycardia.
  • Opioids: enhanced constipation risk.

Moderate Interactions (Monitor Closely)

  • Alzheimer’s drugs (e.g., donepezil): opposite mechanisms may reduce efficacy.
  • Antihypertensives: may increase orthostatic hypotension.
  • Diuretics: heightened risk of urinary retention.

Frequently Asked Questions

Kemadrin, containing the anticholinergic agent Procyclidine, is indicated for the management of Parkinson's disease motor symptoms such as tremor and rigidity, as well as for drug‑induced extrapyramidal reactions like dystonia and akathisia. It helps restore the balance between dopamine and acetylcholine in the central nervous system.

Procyclidine works by competitively blocking muscarinic acetylcholine receptors in the basal ganglia. This antagonism reduces excessive cholinergic activity, allowing dopamine pathways to function more effectively and improving motor control in Parkinsonian and drug‑induced movement disorders.

The appropriate dose of Kemadrin is determined by the prescribing healthcare professional based on the individual’s clinical condition, age, renal function, and response to therapy. Dosage adjustments are made to achieve optimal symptom control while minimizing side effects.

The safety of Kemadrin in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified prescriber.

To order Kemadrin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kemadrin (Procyclidine) is similar to other anticholinergics such as benztropine and trihexyphenidyl in its mechanism of blocking muscarinic receptors. Differences may lie in potency, duration of action, and individual side‑effect profiles, which influence a prescriber’s choice based on patient tolerance and therapeutic response.

Kemadrin tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Protect the product from moisture, direct sunlight, and excessive heat to maintain its stability and potency throughout its shelf life.

Kemadrin is taken orally as a tablet, usually with a glass of water. The exact timing (e.g., with meals or on an empty stomach) and frequency are directed by the prescribing clinician to align with the patient’s therapeutic plan.

Serious risks include confusion, hallucinations, severe tachycardia, acute glaucoma exacerbation, and rare occurrences of neuroleptic malignant syndrome. Patients should be monitored closely for any sudden changes in mental status or cardiovascular symptoms, and medical attention should be sought promptly if they arise.

Kemadrin is contraindicated in patients with known hypersensitivity to Procyclidine or any tablet excipients, those with uncontrolled narrow‑angle glaucoma, and individuals with severe urinary retention or gastrointestinal obstruction. Caution is also advised for patients with significant cardiac disease or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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