Product image of Kemadrin (Procyclidine Hydrochloride) supplied by GNH India

Kemadrin

Active Ingredient:
Procyclidine Hydrochloride
Origin:
EU

Kemadrin (Procyclidine Hydrochloride)

Procyclidine, the active ingredient in Kemadrin, is an anticholinergic presented as an oral tablet for oral administration. It works by reducing excessive cholinergic activity in the basal ganglia, thereby helping to control tremor associated with Parkinson's disease and alleviating drug‑induced extrapyramidal symptoms in patients receiving antipsychotic therapy as part of a comprehensive management plan.

GNH India supplies Kemadrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory conformity across European and global markets.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Procyclidine is an anticholinergic used to manage movement disorders related to excessive cholinergic activity.

  • Parkinson's disease (tremor): Reduces tremor and rigidity associated with the disease.
  • Drug‑induced extrapyramidal symptoms: Alleviates acute dystonia, parkinsonism, and akathisia caused by antipsychotic medications.
  • Parkinsonian syndrome secondary to medication: Improves motor control when symptoms arise from drug therapy.

How It Works

  • Procyclidine acts as a competitive antagonist at muscarinic acetylcholine receptors (M1‑M5) in the central nervous system, especially within the basal ganglia. By blocking these receptors, it diminishes cholinergic neurotransmission, restoring the balance between dopamine and acetylcholine that is disrupted in Parkinsonian states and drug‑induced extrapyramidal reactions, thereby reducing motor symptoms. The antagonism also reduces excessive muscarinic stimulation of striatal neurons, which contributes to tremor and rigidity.

Side Effects

Procyclidine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dry mouth: Reduced salivation leading to thirst.
  • Blurred vision: Transient visual disturbances.
  • Constipation: Decreased gastrointestinal motility.
  • Urinary retention: Difficulty initiating urination.

Serious or Rare Side Effects

  • Acute glaucoma: Sudden increase in intra‑ocular pressure.
  • Severe tachycardia: Rapid heart rate requiring medical attention.
  • Neuroleptic malignant‑like syndrome: Rare life‑threatening reaction with fever and rigidity.

Precautions & Warnings

When prescribing Procyclidine, clinicians should consider several safety precautions.

  • Assess renal and hepatic function: Adjust use in patients with severe impairment.
  • Monitor for anticholinergic burden: Caution in elderly or those on multiple anticholinergics.
  • Avoid in narrow‑angle glaucoma: Risk of precipitating acute attacks.
  • Caution in patients with tachyarrhythmias: May exacerbate heart rate.
  • Pregnancy and lactation: Use only if benefit outweighs risk.
  • Store at ambient temperature: Keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Procyclidine can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticholinergic agents (e.g., atropine, scopolamine): Additive anticholinergic effects may cause severe dryness, constipation, or urinary retention.
  • Quinidine or other CYP2D6 inhibitors: May increase Procyclidine plasma levels, raising toxicity risk.

Moderate Interactions (Monitor Closely)

  • Antipsychotics (e.g., haloperidol): May require dose adjustment to balance dopaminergic and cholinergic activity.
  • Antihistamines with anticholinergic properties: May enhance side‑effect profile.
  • Beta‑blockers: Potential for additive cardiovascular effects such as bradycardia.

Frequently Asked Questions

Kemadrin contains the active ingredient Procyclidine, an anticholinergic medication prescribed to reduce tremor in Parkinson's disease and to treat drug‑induced extrapyramidal symptoms such as acute dystonia, parkinsonism, and akathisia that can arise from antipsychotic therapy.

Procyclidine works by competitively blocking muscarinic acetylcholine receptors in the central nervous system, especially within the basal ganglia. This antagonism lowers cholinergic activity, helping to restore the dopamine‑acetylcholine balance that is disrupted in Parkinsonian states and drug‑induced movement disorders.

The appropriate dose of Kemadrin is determined by a qualified prescriber based on the individual patient's condition, response, and tolerability. Dosing regimens are tailored to each patient and should follow the prescribing information provided by the healthcare professional.

Kemadrin is classified as a prescription‑only medication and should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the fetus or infant. Clinicians must evaluate the risk‑benefit profile for each patient and consider alternative therapies when appropriate.

To order Kemadrin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Kemadrin (Procyclidine) belongs to the anticholinergic class, which differs from dopaminergic agents such as levodopa or dopamine agonists. While anticholinergics are particularly effective for tremor and drug‑induced extrapyramidal symptoms, they may have a higher incidence of anticholinergic side effects, making patient selection and monitoring essential.

Kemadrin tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure that it is out of reach of children and pets.

Kemadrin is administered orally, typically as a tablet taken with or without food as directed by the prescribing physician. The exact timing and frequency depend on the individual treatment plan and should be followed according to the healthcare provider's instructions.

Serious risks of Kemadrin include acute glaucoma, severe tachycardia, and rare neuroleptic malignant‑like syndrome, which can present with high fever, muscle rigidity, and autonomic instability. Patients should seek immediate medical attention if they experience sudden visual changes, rapid heart rate, or unexplained fever and rigidity.

Kemadrin is contraindicated in patients with known hypersensitivity to Procyclidine or other anticholinergics, those with narrow‑angle glaucoma, severe urinary retention, or uncontrolled tachyarrhythmias. Caution is also advised for elderly patients and individuals taking multiple anticholinergic medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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