Product image of Keol-C (Oxygen) supplied by GNH India

Keol-C

Active Ingredient:
Oxygen
Origin:
EU

Keol-C (Oxygen)

Oxygen, the active ingredient in Keol-C, is a medical gas presented as a supplemental oxygen source for inhalation use. It is employed to increase arterial oxygen tension, supporting patients with respiratory insufficiency, hypoxaemia, or during peri‑operative care.

GNH India supplies Keol-C as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to EU quality standards, provides full regulatory documentation, and ensures reliable logistics and dedicated technical support for global distribution.

Manufacturer / TM Owner

Air Liquide Sante International

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Indications & Clinical Uses

  • Keol‑C provides supplemental oxygen for conditions affecting the respiratory system and oxygenation.
  • Acute hypoxemia: restores adequate arterial oxygen levels to prevent tissue hypoxia.
  • Chronic obstructive pulmonary disease (COPD) exacerbations: improves oxygen saturation and reduces work of breathing.
  • Peri‑operative care: maintains optimal oxygenation during anesthesia and surgery.
  • Carbon monoxide poisoning: displaces carbon monoxide from hemoglobin and accelerates recovery.

How It Works

  • Supplemental oxygen delivered via Keol‑C increases the partial pressure of oxygen in the alveoli, enhancing diffusion across the alveolar‑capillary membrane into the bloodstream. The elevated arterial oxygen tension raises tissue oxygen delivery, supporting cellular metabolism and reducing hypoxic stress. This effect is achieved without pharmacologic receptor interaction, relying on physical diffusion driven by concentration gradients. By improving oxygen availability, it helps maintain organ function during periods of reduced pulmonary gas exchange.

Side Effects

Oxygen therapy may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects

  • Nasal dryness or irritation
  • Cough
  • Headache
  • Dizziness
  • Fatigue
  • Mild chest discomfort

Serious or Rare Side Effects

  • Pulmonary oxygen toxicity leading to inflammation
  • Seizures due to hyperoxia
  • Retinopathy of prematurity in neonates
  • Fire or explosion risk in the presence of flammable materials

Precautions & Warnings

When using Keol‑C, several safety measures and patient assessments are recommended.

  • Assess oxygen saturation before initiation: use pulse oximetry to confirm need.
  • Adjust flow rate to target SpO₂: maintain recommended clinical range.
  • Monitor for signs of hyperoxia: watch for visual changes or respiratory distress.
  • Avoid use with open flames or smoking: oxygen supports combustion.
  • Use appropriate delivery device: ensure correct fitting of mask or cannula.
  • Store at ambient temperature: keep cylinders in a well‑ventilated, dry area away from heat sources and open flames.

Avoid Interactions

Oxygen can interact with certain agents and environmental factors, requiring careful management.

Major Interactions (Avoid)

  • Flammable anesthetic gases: avoid high‑concentration oxygen with nitrous oxide or volatile agents.
  • Methoxyflurane: contraindicated due to increased nephrotoxicity risk.

Moderate Interactions (Monitor Closely)

  • Bronchodilators: monitor for enhanced respiratory response.
  • Sedatives and opioids: observe for additive respiratory depression.
  • Bleomycin chemotherapy: watch for increased pulmonary toxicity.
  • High‑concentration nitric oxide therapy: assess for oxidative stress.

Frequently Asked Questions

Keol‑C is a medical gas that contains oxygen and is used to provide supplemental oxygen to patients who have low blood‑oxygen levels. It is commonly employed in acute hypoxemia, chronic respiratory conditions such as COPD, during surgery to maintain adequate oxygenation, and as part of treatment for carbon‑monoxide poisoning.

Oxygen delivered by Keol‑C increases the partial pressure of oxygen in the lungs, which enhances diffusion across the alveolar‑capillary membrane into the bloodstream. The rise in arterial oxygen tension improves the amount of oxygen that reaches tissues, supporting cellular metabolism and preventing hypoxic injury.

The dose of Keol‑C is individualized. A prescriber determines the appropriate flow rate, concentration and duration of therapy based on the patient’s oxygen saturation, underlying condition and clinical response. The exact regimen is set by the treating healthcare professional.

Oxygen is generally considered safe for pregnant or breastfeeding patients when clinically indicated, as it does not cross the placenta in harmful amounts. Nevertheless, its use should be limited to situations where the benefits outweigh any potential risks and should be overseen by a qualified medical professional.

To order Keol‑C, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Keol‑C is supplied as a medical‑grade oxygen cylinder, offering high‑purity gas for precise flow‑rate control. Compared with liquid oxygen systems or oxygen concentrators, cylinders provide portability and immediate availability but require proper storage and handling. The choice depends on clinical setting, duration of therapy and infrastructure.

Keol‑C cylinders should be stored at ambient temperature in a well‑ventilated, dry area away from heat sources, open flames and combustible materials. They must be secured upright, protected from physical damage, and handled only by trained personnel using appropriate cylinder‑handling equipment.

Keol‑C is administered by connecting the oxygen cylinder to a regulator and then to a delivery device such as a face mask, nasal cannula or non‑rebreather mask. The prescriber sets the flow rate, and the patient inhales the oxygen directly through the chosen interface.

Serious risks include pulmonary oxygen toxicity, which can cause inflammation and lung injury, and the potential for seizures due to hyperoxia. In neonates, prolonged high‑concentration exposure may lead to retinopathy of prematurity. Additionally, oxygen supports combustion, creating a fire or explosion hazard if proper safety measures are not followed.

Keol‑C should be avoided in patients with known hypersensitivity to oxygen therapy equipment, those with untreated pneumothorax, or individuals at high risk of oxygen‑induced lung injury such as patients receiving high‑dose bleomycin. It should also not be used in environments where flammable gases or vapors are present without appropriate safety controls.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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