Product image of Keol (Oxygen) supplied by GNH India

Keol

Active Ingredient:
Oxygen
Origin:
EU

Keol (Oxygen)

Oxygen, the active ingredient in Keol, is a Medical gas presented as a medical gas for inhalation use. It provides supplemental oxygen to patients with hypoxemia, respiratory distress, COPD exacerbations and those requiring post‑operative oxygen therapy.

GNH India supplies Keol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Air Liquide Sante International

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Indications & Clinical Uses

  • Keol is used in respiratory therapy to improve oxygenation in several clinical conditions.
  • Hypoxemia: Increases arterial oxygen tension to correct low blood‑oxygen levels.
  • Respiratory distress: Supplies additional oxygen to relieve acute breathing difficulty.
  • COPD exacerbations: Supports patients during flare‑ups to maintain adequate oxygen saturation.
  • Post‑operative oxygen therapy: Provides supplemental oxygen after surgery to promote recovery and prevent hypoxia.

How It Works

  • Oxygen delivered via inhalation diffuses across the alveolar membrane into the pulmonary capillaries, raising the partial pressure of arterial oxygen (PaO₂). This enhances the oxygen gradient for tissue uptake, improving cellular respiration and overall tissue oxygenation without directly interacting with receptors or enzymes.

Side Effects

Supplemental oxygen can be associated with both frequent and rare adverse reactions.

Common Side Effects

  • Nasal dryness or irritation
  • Headache
  • Cough or throat discomfort
  • Dizziness or light‑headedness
  • Fatigue
  • Mild nausea

Serious or Rare Side Effects

  • Oxygen toxicity leading to lung injury
  • Seizures in high‑concentration exposure
  • Fire or explosion hazard if exposed to ignition sources
  • Retinal damage in premature infants (retinopathy of prematurity)
  • Severe hypercapnia in patients with chronic CO₂ retention

Precautions & Warnings

Oxygen therapy requires careful assessment and monitoring to ensure safety.

  • Assess need: Confirm indication and target oxygen saturation before initiating therapy.
  • Monitor: Continuously check SpO₂ and adjust flow rates as needed.
  • Hypercapnia risk: Avoid in patients with CO₂ retention unless ventilatory support is provided.
  • Delivery device: Use appropriate cannula or mask to prevent mucosal injury.
  • Fire safety: Keep away from open flames, smoking materials, and combustible gases.
  • Store at ambient temperature: Keep cylinders in a well‑ventilated, dry area away from heat and ignition sources.

Avoid Interactions

Oxygen can interact with certain substances, influencing safety and efficacy.

Major Interactions (Avoid)

  • Flammable gases (e.g., methane, propane): Increased fire and explosion risk.
  • Nitrous oxide: Potentiates fire hazard when used concurrently.

Moderate Interactions (Monitor Closely)

  • Carbon monoxide: Impairs oxygen delivery; monitor for CO exposure.
  • Sedative agents (e.g., benzodiazepines, opioids): May deepen respiratory depression; observe respiratory status.
  • Bronchodilators: May enhance bronchodilation; adjust dosing if needed.

Frequently Asked Questions

Keol is a medical gas containing oxygen that is used to provide supplemental oxygen therapy for patients with low blood‑oxygen levels, such as those experiencing hypoxemia, respiratory distress, COPD exacerbations, or requiring post‑operative oxygen support.

Oxygen in Keol is inhaled and diffuses across the alveolar membrane into the bloodstream, raising arterial oxygen tension (PaO₂). This increased oxygen availability enhances tissue oxygenation, supporting cellular metabolism and improving overall respiratory function.

The dose of Keol is determined by the prescribing clinician based on the patient’s oxygen saturation, underlying condition, and delivery device. The prescriber sets the flow rate and duration appropriate for each individual case.

The safety of Keol (oxygen) in pregnancy or while breastfeeding has not been definitively established. Clinicians should evaluate the risk‑benefit ratio for each patient and consider alternative therapies if appropriate.

To order Keol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Keol provides medical‑grade oxygen in a gas cylinder format, similar to other supplemental oxygen products. Compared with liquid oxygen systems, Keol offers easier handling and rapid availability, while maintaining comparable purity and therapeutic effect for respiratory support.

Keol cylinders should be stored at ambient temperature in a well‑ventilated, dry area away from heat sources and open flames. Keep cylinders upright, secure them to prevent tipping, and protect the valve from damage. Follow local regulations for medical gas storage.

Keol is administered by connecting the oxygen cylinder to a suitable delivery device, such as a nasal cannula, simple face mask, or non‑rebreather mask. The prescriber sets the flow rate, and the patient inhales the oxygen directly from the device.

The most serious risks include oxygen toxicity leading to lung injury, fire or explosion hazards when exposed to ignition sources, and severe hypercapnia in patients with chronic CO₂ retention. Continuous monitoring and adherence to safety protocols are essential.

Keol should be avoided in patients with known hypersensitivity to oxygen, those with uncontrolled hypercapnia without ventilatory support, and individuals in environments where fire risk cannot be adequately controlled. Clinicians must assess each patient’s suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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