Product image of Keplat (Ketoprofen) supplied by GNH India

Keplat

Active Ingredient:
Ketoprofen
Origin:
EU

Keplat (Ketoprofen)

Ketoprofen, the active ingredient in Keplat, is a nonsteroidal anti-inflammatory drug (NSAID) presented as a transdermal patch for topical administration. It provides analgesic and anti‑inflammatory effects for the relief of mild to moderate pain associated with musculoskeletal disorders, osteoarthritis and rheumatoid arthritis in adult patients.

GNH India supplies Keplat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Hisamitsu Italia S.R.L.

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Indications & Clinical Uses

Ketoprofen is used to manage pain and inflammation in several musculoskeletal and arthritic conditions.

  • Musculoskeletal pain: reduces pain and improves function in acute and chronic muscle or joint discomfort.
  • Osteoarthritis: alleviates joint pain and stiffness, enhancing mobility.
  • Rheumatoid arthritis: helps control inflammatory pain and swelling in affected joints.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain signaling, and fever at the site of application.

Side Effects

Ketoprofen transdermal patches may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Skin irritation at application site: redness, itching or rash.
  • Localized burning or stinging sensation.
  • Mild headache.
  • Gastrointestinal discomfort: nausea or dyspepsia.
  • Dizziness.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling of face, lips or throat, hives.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or sudden decrease in kidney function.
  • Hepatotoxicity with elevated liver enzymes.

Precautions & Warnings

When using Ketoprofen patches, certain precautions should be observed to minimize risks.

  • Assess renal function: avoid use in patients with severe renal impairment.
  • Evaluate hepatic status: use cautiously in liver disease.
  • Monitor cardiovascular risk: NSAIDs may increase risk of thrombotic events.
  • Avoid concurrent use with other NSAIDs or anticoagulants without medical advice.
  • Check for hypersensitivity: discontinue if signs of allergic reaction appear.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
  • Corticosteroids: additive risk of ulceration.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: may exacerbate renal impairment.
  • Lithium: NSAIDs can raise lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Keplat is a ketoprofen‑containing transdermal patch indicated for the relief of mild to moderate pain associated with musculoskeletal conditions, osteoarthritis and rheumatoid arthritis. It provides localized anti‑inflammatory and analgesic effects when applied to the skin over the affected area.

Ketoprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins—key mediators of inflammation, pain and fever. Lower prostaglandin levels diminish the inflammatory response and alleviate pain at the site of application.

The appropriate dose of Keplat is determined by the prescribing healthcare professional based on the patient’s condition, severity of symptoms, and overall health status. The prescriber will select the number of patches, size and duration of therapy that best suit the individual’s therapeutic needs.

Safety data for ketoprofen transdermal patches in pregnancy and lactation are limited. Because NSAIDs can affect fetal development and may be excreted in breast milk, the product should be used only if clearly needed and after a risk‑benefit assessment by a qualified healthcare provider.

To order Keplat, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Keplat delivers ketoprofen directly through the skin, offering targeted pain relief with potentially lower systemic exposure compared with oral NSAIDs such as ibuprofen or naproxen. This route can reduce gastrointestinal side effects but still carries typical NSAID risks, including cardiovascular and renal considerations.

Keplat patches should be stored at room temperature, below 25 °C, in their original, sealed packaging. Protect them from moisture, direct sunlight and extreme temperatures. Keep the product out of reach of children and do not use patches that are damaged or past their expiration date.

The patch is applied to clean, dry, hair‑free skin on the affected area. Press firmly for several seconds to ensure good contact, then cover with the supplied protective film if required. The patch remains in place for the duration prescribed, after which it should be removed, folded inward and disposed of safely.

Serious adverse reactions can include severe allergic responses such as angio‑edema or anaphylaxis, skin disorders like Stevens‑Johnson syndrome, gastrointestinal ulceration or bleeding, and renal or hepatic impairment. Patients should seek immediate medical attention if they experience swelling of the face, persistent stomach pain, blood in stools or urine, or sudden loss of kidney function.

Keplat should be avoided in individuals with known hypersensitivity to ketoprofen or any other NSAIDs, those with active gastrointestinal ulcer disease, severe renal or hepatic impairment, and patients who have experienced previous serious cardiovascular events related to NSAID use. Consultation with a healthcare professional is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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