Product image of Keppra (Levetiracetam) supplied by GNH India

Keppra

Active Ingredient:
Levetiracetam
Origin:
EU

Keppra (Levetiracetam)

Levetiracetam, the active ingredient in Keppra, is an antiepileptic presented as an intravenous injection for intravenous use. It is indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients requiring rapid seizure control, and is commonly employed in acute care settings such as emergency departments and intensive care units.

GNH India supplies Keppra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and cold‑chain logistics where required.

Manufacturer / TM Owner

Ucb Pharma S.A.

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Indications & Clinical Uses

Levetiracetam is an antiepileptic medication that reduces neuronal excitability across several seizure types, offering rapid control in acute settings.

  • Partial‑onset seizures: helps achieve seizure freedom or significant reduction in seizure frequency in patients with focal epilepsy.
  • Generalized tonic‑clonic seizures: provides control of convulsive episodes, decreasing the risk of injury and status epilepticus.
  • Myoclonic seizures: diminishes rapid muscle jerks, improving daily functioning and quality of life.
  • Adjunctive therapy: may be combined with other antiepileptic drugs to improve seizure control when monotherapy does not achieve desired outcomes.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, stabilizing synaptic transmission and reducing excessive neuronal firing. By limiting glutamate release and dampening excitatory pathways, the drug lowers the likelihood of seizure propagation without significant effects on ion channels or G‑protein coupled receptors.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Somnolence
  • Fatigue
  • Headache
  • Irritability
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions such as anaphylaxis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Blood dyscrasias including neutropenia or thrombocytopenia
  • Suicidal thoughts or behavior
  • Severe depression or mood changes
  • Respiratory depression in vulnerable patients

Precautions & Warnings

When using levetiracetam, several precautionary measures should be observed to ensure safe therapy.

  • Renal impairment: assess function and consider dose adjustment.
  • Hepatic impairment: monitor liver enzymes and adjust if needed.
  • Pregnancy: risk unknown; use only if benefits outweigh potential risks.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Behavioral changes: observe for irritability, aggression, or mood swings.
  • Store at room temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levetiracetam has a relatively low interaction profile, but certain drug combinations require attention.

Major Interactions (Avoid)

  • Co‑administration with other central nervous system depressants (e.g., barbiturates, opioids) may cause excessive sedation or respiratory depression.

Moderate Interactions (Monitor Closely)

  • Strong enzyme inducers such as carbamazepine, phenytoin or phenobarbital can lower levetiracetam plasma levels.
  • Valproic acid may increase levetiracetam concentrations, requiring monitoring.
  • Oral contraceptives: levetiracetam may reduce hormonal efficacy, advise alternative contraception.
  • Antifungal agents like fluconazole may modestly raise levetiracetam levels.

Frequently Asked Questions

Keppra (levetiracetam) is an antiepileptic indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients who need rapid seizure control, often administered intravenously in acute care settings.

Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and reducing neuronal excitability. This action helps prevent the spread of seizure activity without directly affecting ion channels.

The dosage of levetiracetam is individualized by the prescribing clinician based on factors such as seizure type, patient age, renal function and concomitant therapies. No fixed regimen is provided here; dosing decisions are made by the treating physician.

Safety data for levetiracetam during pregnancy and lactation are limited. It is classified as pregnancy category unknown, and use is generally reserved for situations where the potential benefit outweighs any possible risk to the fetus. Breastfeeding mothers should consult their healthcare provider.

To place an order, submit an enquiry on the Keppra product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and required import documentation.

Compared with older agents such as carbamazepine or phenytoin, levetiracetam has a more favorable drug‑interaction profile, rapid onset of action when given intravenously, and is generally well tolerated. However, individual response varies, and choice of therapy depends on seizure type, comorbidities and clinician preference.

Keppra for injection should be stored at room temperature, below 25 °C, in its original packaging, protected from moisture and light. Prior to administration, inspect the solution for particulate matter and use aseptic technique as recommended.

Keppra is supplied as an intravenous solution that is administered by slow infusion into a vein, typically under the supervision of a qualified healthcare professional in a hospital or emergency setting. The infusion rate and duration are determined by the prescriber.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, blood dyscrasias, and emergence of suicidal thoughts or severe depression. Patients should be monitored for these signs, and any concerning symptoms require immediate medical attention.

Keppra is contraindicated in patients with known hypersensitivity to levetiracetam or any of the formulation components. Caution is advised in individuals with severe renal impairment, uncontrolled psychiatric conditions, or those taking other central nervous system depressants without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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