Product image of Keppra (Levetiracetam) supplied by GNH India

Keppra

Active Ingredient:
Levetiracetam
Origin:
EU

Keppra (Levetiracetam)

Levetiracetam, the active ingredient in Keppra, is an anticonvulsant presented as an oral tablet for oral use. It is prescribed to manage various seizure types in patients with epilepsy, helping to reduce the frequency and severity of seizures. It belongs to the class of antiepileptic drugs and is indicated for patients aged two years and older.

GNH India supplies Keppra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, including major hospital networks, independent pharmacies and specialized clinics across Europe, Asia and the Americas.

Manufacturer / TM Owner

Ucb Pharma S.A.

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Indications & Clinical Uses

  • Levetiracetam (Keppra) is used to treat seizure disorders within the antiepileptic drug class.
  • Partial-onset seizures: reduces seizure frequency in patients with focal epilepsy.
  • Generalized tonic-clonic seizures: helps control convulsive episodes in patients with generalized epilepsy.
  • Myoclonic seizures: decreases the occurrence of rapid muscle jerks in appropriate patients.

How It Works

  • Levetiracetam exerts its antiepileptic effect by binding selectively to the synaptic vesicle protein 2A (SV2A) located on presynaptic neurons. This interaction modulates the release of neurotransmitters, stabilizing synaptic transmission and reducing neuronal hyperexcitability that underlies seizure activity. By influencing calcium‑dependent exocytosis, levetiracetam helps maintain a balanced excitatory‑inhibitory environment in the brain.

Side Effects

Levetiracetam may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness: a sensation of light‑headedness or unsteadiness.
  • Fatigue: feeling unusually tired or lacking energy.
  • Headache: mild to moderate pain in the head region.
  • Irritability: increased agitation or mood changes.

Serious or Rare Side Effects

  • Severe allergic reactions: including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal thoughts or behavior: new or worsening depression, anxiety, or suicidal ideation.
  • Severe skin rash: widespread rash that may require medical attention.
  • Blood disorders: such as neutropenia or thrombocytopenia.

Precautions & Warnings

  • Before initiating levetiracetam, clinicians should consider several precautionary measures to ensure safe use.
  • Renal impairment: adjust dose based on creatinine clearance.
  • Hepatic impairment: monitor liver function tests.
  • Psychiatric symptoms: monitor for mood changes, depression, or suicidal ideation.
  • Pregnancy: discuss potential risks as safety data are limited.
  • Driving and operating machinery: avoid until individual response is known.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: may lower levetiracetam plasma concentrations.
  • Phenytoin: may reduce levetiracetam levels.
  • Phenobarbital: may decrease levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression.
  • Other antiepileptics: may require dose adjustments.
  • Renal excretion inhibitors (e.g., probenecid): may increase levetiracetam levels.

Frequently Asked Questions

Keppra, whose active ingredient is levetiracetam, is prescribed to treat several types of epilepsy. It is indicated for partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce the frequency and severity of seizure episodes in patients diagnosed with these conditions.

Levetiracetam works by binding to the synaptic vesicle protein 2A (SV2A) on presynaptic neurons. This binding modulates the release of neurotransmitters, stabilising synaptic activity and decreasing neuronal hyper‑excitability that can trigger seizures. The exact downstream pathways are still being studied, but SV2A interaction is central to its antiepileptic effect.

The dosage of Keppra is individualized and must be determined by a qualified prescriber. Factors such as the patient’s age, weight, renal function, and specific seizure type influence the prescribed amount. Healthcare professionals will calculate the appropriate dose and any necessary adjustments.

Safety data for levetiracetam in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting or continuing therapy.

To order Keppra, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Keppra differs from many traditional antiepileptics such as carbamazepine or valproate because it has a unique mechanism involving SV2A binding and does not significantly affect hepatic enzyme systems. This often results in fewer drug‑drug interactions and a more favourable side‑effect profile, although individual response varies and treatment choice should be guided by the clinician.

Keppra tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children. No refrigeration is required for this oral tablet formulation.

Keppra is taken orally as a tablet. The tablet should be swallowed whole with a glass of water and can be taken with or without food, unless otherwise directed by the prescriber. The exact timing and frequency are determined by the treating physician based on the patient’s therapeutic needs.

The most serious risks include severe allergic reactions such as Stevens‑Johnson syndrome, life‑threatening skin rashes, and psychiatric effects like new or worsening depression, anxiety, or suicidal thoughts. Patients should be monitored closely for any signs of these reactions and seek immediate medical attention if they occur.

Keppra should be avoided in individuals with a known hypersensitivity to levetiracetam or any of its excipients. Patients with severe renal impairment may require special dosing considerations and should be evaluated by a healthcare professional before use. As always, the prescriber will assess suitability on a case‑by‑case basis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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