Product image of Keppra (Levetiracetam) supplied by GNH India

Keppra

Active Ingredient:
Levetiracetam
Origin:
EU

Keppra (Levetiracetam)

Levetiracetam, the active ingredient in Keppra, is an anticonvulsant presented as an oral tablet for oral use. It is employed to control various types of epileptic seizures in adult and pediatric patients.
GNH India supplies Keppra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ucb Pharma S.A.

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Indications & Clinical Uses

Levetiracetam is indicated for the management of several seizure disorders within the broader epilepsy therapeutic area.

  • Partial onset seizures: Reduces the frequency of focal seizures in patients with epilepsy.
  • Myoclonic seizures: Controls sudden, brief muscle jerks associated with myoclonic epilepsy.
  • Primary generalized tonic‑clonic seizures: Decreases the occurrence of generalized convulsive seizures in both adults and children.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic transmission, diminishes excessive neuronal firing, and stabilizes neuronal excitability, thereby helping to prevent the initiation and spread of epileptic seizures.

Side Effects

Levetiracetam may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Dizziness: A sensation of light‑headedness or unsteadiness.
  • Somnolence: Increased sleepiness or fatigue during the day.
  • Headache: Mild to moderate pain in the head region.
  • Nausea: Feeling of stomach upset or urge to vomit.

Serious or Rare Side Effects

  • Severe allergic reactions: Including rash, swelling, or difficulty breathing.
  • Stevens‑Johnson syndrome: Rare but serious skin disorder with blistering.
  • Suicidal thoughts or severe depression: Mood changes requiring immediate medical attention.

Precautions & Warnings

When prescribing levetiracetam, clinicians should consider several safety aspects.

  • Renal function: Adjust dosage in patients with impaired renal clearance.
  • Psychiatric history: Monitor for mood changes, depression, or suicidal ideation.
  • Concomitant CNS depressants: Use caution when combined with other sedating agents.
  • Pregnancy: Evaluate risk‑benefit ratio as safety data are limited.
  • Store at ambient temperature: Keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: May lower levetiracetam plasma concentrations.
  • Phenobarbital: Can reduce levetiracetam levels, decreasing seizure control.
  • Phenytoin: May decrease levetiracetam exposure, risking breakthrough seizures.

Moderate Interactions (Monitor Closely)

  • Alcohol: May enhance central nervous system depression and dizziness.
  • Other antiepileptics: Potential additive effects on sedation or seizure threshold.
  • Hormonal contraceptives: Levetiracetam may reduce contraceptive effectiveness, requiring additional protection.

Frequently Asked Questions

Keppra, whose active ingredient is levetiracetam, is prescribed for the control of partial onset seizures, myoclonic seizures, and primary generalized tonic‑clonic seizures in both adult and pediatric patients with epilepsy.

Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and reducing neuronal hyper‑excitability. This stabilises synaptic activity and helps prevent the initiation and spread of epileptic discharges.

The appropriate dose of Keppra is determined individually by the prescribing healthcare professional based on the patient’s age, weight, renal function, and seizure type. Patients should follow the prescriber’s instructions precisely.

Safety data for levetiracetam in pregnancy and lactation are limited. The prescriber will weigh potential benefits against possible risks and may recommend alternative therapy or close monitoring if use is considered necessary.

To request Keppra, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older agents such as carbamazepine or phenytoin, levetiracetam has a distinct mechanism (SV2A binding) and generally fewer drug‑enzyme interactions, which can simplify combination therapy. However, individual response and side‑effect profiles vary, so treatment choice is personalised.

Keppra tablets should be stored at ambient temperature, below 25 °C, in the original blister pack. Keep them away from moisture, direct sunlight and excessive heat to maintain product stability.

Keppra is taken orally, usually as a tablet, with or without food. The prescriber will advise the dosing schedule—often twice daily—but patients must follow the exact instructions provided on the prescription label.

Serious adverse events, though uncommon, include severe allergic reactions, Stevens‑Johnson syndrome, and emergence of suicidal thoughts or major depression. Any sudden mood changes, rash, or breathing difficulties should prompt immediate medical evaluation.

Keppra is contraindicated in patients with known hypersensitivity to levetiracetam or any tablet excipients. Caution is advised in individuals with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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