Product image of Keracutan (Acitretin) supplied by GNH India

Keracutan

Active Ingredient:
Acitretin
Origin:
EU

Keracutan (Acitretin)

Acitretin, the active ingredient in Keracutan, is a retinoid presented as an oral tablet for oral use. It is indicated for the treatment of severe plaque psoriasis and other disorders of keratinization, helping to normalize skin cell growth in adult patients.

GNH India supplies Keracutan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows EU‑quality standards and provides reliable global distribution for this prescription medication.

Manufacturer / TM Owner

Pelpharma Handels Gmbh

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Indications & Clinical Uses

Acitretin is a systemic retinoid used in the management of disorders characterized by abnormal keratinization.

  • Severe plaque psoriasis: reduces scaling and plaque thickness by normalizing keratinocyte differentiation.
  • Ichthyosis vulgaris: improves skin texture by decreasing epidermal hyperproliferation.
  • Other keratinization disorders: helps control abnormal skin cell turnover in conditions such as keratosis pilaris.

How It Works

  • Acitretin binds to nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), modulating gene transcription that regulates keratinocyte differentiation and proliferation. This results in normalized epidermal growth, reduced hyperkeratosis, and anti‑inflammatory effects that improve psoriatic lesions and other keratinization abnormalities.

Side Effects

Common Side Effects

  • Dry skin: increased xerosis and scaling.
  • Cheilitis: inflammation and cracking of the lips.
  • Elevated triglycerides: lipid abnormalities that may require monitoring.
  • Hair loss: temporary alopecia in some patients.

Serious or Rare Side Effects

  • Hepatotoxicity: elevation of liver enzymes indicating potential liver injury.
  • Severe hyperlipidemia: marked increase in cholesterol or triglyceride levels.
  • Pseudotumor cerebri: intracranial hypertension presenting with headache and visual changes.

Precautions & Warnings

Acitretin requires careful monitoring due to its teratogenic potential and metabolic effects.

  • Pregnancy contraindication: teratogenic (Category X); avoid use in women of childbearing potential.
  • Contraception requirement: effective contraception must be maintained during treatment and for at least three years after discontinuation.
  • Liver function monitoring: assess hepatic enzymes before initiation and periodically during therapy.
  • Lipid profile monitoring: check serum triglycerides and cholesterol regularly.
  • Visual acuity monitoring: assess for signs of intracranial hypertension such as headaches or visual disturbances.
  • Store at ambient temperature: keep below 25°C, retain in the original pack, and protect from moisture.

Avoid Interactions

Acitretin may interact with several drug classes, requiring avoidance or close monitoring.

Major Interactions (Avoid)

  • Tetracycline antibiotics: increased risk of intracranial hypertension.
  • Vitamin A supplements: additive teratogenicity and hypervitaminosis A.
  • Combined oral retinoids: heightened systemic toxicity.

Moderate Interactions (Monitor Closely)

  • Lipid‑lowering agents (statins): may require dose adjustment due to altered lipid levels.
  • Anticoagulants (warfarin): possible alteration of INR and bleeding risk.
  • Phototherapy: may enhance photosensitivity and skin reactions.

Frequently Asked Questions

Keracutan, containing the active ingredient acitretin, is prescribed for severe plaque psoriasis and other disorders of keratinization such as ichthyosis vulgaris. It works systemically to normalize skin cell growth and reduce scaling in adult patients.

Acitretin binds to nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR), altering gene transcription that controls keratinocyte differentiation and proliferation. This normalizes epidermal turnover, reduces hyperkeratosis, and exerts anti‑inflammatory effects.

The dosage of Keracutan is individualized by the prescribing clinician based on disease severity, patient weight, and laboratory parameters. The prescriber determines the appropriate starting dose and any subsequent adjustments.

Acitretin is classified as pregnancy category X and is contraindicated in pregnancy because of its high teratogenic risk. It is also not recommended during breastfeeding, and effective contraception must be used throughout treatment and for three years after stopping the drug.

To order Keracutan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

The primary alternative systemic therapy for severe psoriasis is methotrexate, which acts as an antimetabolite and immunosuppressant. Unlike methotrexate, acitretin is a retinoid that primarily normalizes keratinocyte differentiation and has a different side‑effect profile, notably a higher risk of lipid abnormalities and teratogenicity.

Keracutan tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture. Keep the container tightly closed and out of direct sunlight to maintain product stability.

Keracutan is taken orally as a tablet, usually with a full glass of water. It may be taken with or without food, but patients should follow the specific instructions provided by their healthcare professional.

Serious risks include hepatotoxicity, severe hyperlipidemia, and pseudotumor cerebri (intracranial hypertension). Patients should be monitored regularly for liver enzyme elevations, lipid changes, and any new headaches or visual disturbances.

Keracutan should not be used by pregnant women, women planning pregnancy, or anyone who cannot maintain effective contraception for at least three years after stopping therapy. It is also contraindicated in patients with severe liver disease or uncontrolled hyperlipidemia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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