Product image of Keraflox (Prulifloxacin) supplied by GNH India

Keraflox

Active Ingredient:
Prulifloxacin
Origin:
EU

Keraflox (Prulifloxacin)

Prulifloxacin, the active ingredient in Keraflox, is a fluoroquinolone presented as an oral tablet for oral use. It provides broad‑spectrum antibacterial activity and is indicated for the treatment of urinary tract infections, respiratory tract infections, and skin and soft‑tissue infections in adult patients, with dosage determined by the prescribing clinician.

GNH India supplies Keraflox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, transplant centres and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable logistics for global distribution.

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Indications & Clinical Uses

Prulifloxacin is used to treat bacterial infections affecting several organ systems.

  • Urinary tract infection: effective in eradicating susceptible bacteria causing cystitis and pyelonephritis.
  • Respiratory tract infection: treats community‑acquired pneumonia and acute exacerbations of chronic bronchitis.
  • Skin and soft‑tissue infection: clears infections such as cellulitis, abscesses and wound infections caused by susceptible organisms.

How It Works

  • Prulifloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By blocking these targets, the drug prevents bacterial DNA supercoiling and segregation, leading to bactericidal activity against a broad range of Gram‑negative and Gram‑positive pathogens.

Side Effects

Prulifloxacin may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: transient cranial discomfort.
  • Rash: mild skin erythema or itching.

Serious or Rare Side Effects

  • Tendon rupture: especially in the Achilles tendon, may occur without warning.
  • QT interval prolongation: can predispose to cardiac arrhythmias.
  • Severe allergic reactions: including anaphylaxis, angioedema, or Stevens‑Johnson syndrome.

Precautions & Warnings

Prulifloxacin should be used with caution in specific clinical situations.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hypersensitivity: avoid in patients with known allergy to fluoroquinolones.
  • Elderly patients: increased risk of tendon injury; advise against sudden strenuous activity.
  • Concomitant QT‑prolonging drugs: assess cardiac risk before co‑administration.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Prulifloxacin can interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: may markedly reduce prulifloxacin absorption.
  • Warfarin: can enhance anticoagulant effect, increasing bleeding risk.
  • Systemic corticosteroids: may increase the likelihood of tendon rupture.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase central nervous system stimulation.
  • Theophylline: plasma concentrations may rise, risking toxicity.
  • Diabetes medications: possible alteration of glycemic control.

Frequently Asked Questions

Keraflox contains prulifloxacin, a fluoroquinolone antibacterial indicated for the treatment of adult urinary tract infections, respiratory tract infections such as pneumonia, and skin and soft‑tissue infections caused by susceptible bacteria.

Prulifloxacin exerts its effect by inhibiting bacterial DNA gyrase and topoisomerase IV. These enzymes are essential for DNA replication and transcription, and their blockade leads to bacterial cell death.

The specific dose and treatment duration of Keraflox are determined by the prescribing clinician based on the infection type, severity, patient characteristics, and local prescribing guidelines.

Safety data for prulifloxacin in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk, and the decision must be made by a qualified healthcare professional.

To request Keraflox, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Keraflox (prulifloxacin) shares the class‑wide mechanism of DNA‑gyrase inhibition with agents such as levofloxacin and ciprofloxacin. Compared with some alternatives, prulifloxacin offers a once‑daily dosing schedule and a broad spectrum against both Gram‑negative and Gram‑positive pathogens, though individual susceptibility patterns and safety profiles may differ.

Keraflox tablets should be stored at room temperature, below 25 °C, in the original blister pack. Protect them from moisture, excessive heat and direct sunlight to maintain product stability.

Keraflox is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing relative to meals.

Serious adverse events include tendon rupture (especially the Achilles tendon), QT‑interval prolongation leading to cardiac arrhythmias, and severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if these symptoms occur.

Keraflox is contraindicated in individuals with a known hypersensitivity to prulifloxacin or any fluoroquinolone, in children and adolescents whose skeletal systems are still developing, and in patients with a history of tendon disorders related to fluoroquinolone therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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