Product image of Keral (Dexketoprofen) supplied by GNH India

Keral

Active Ingredient:
Dexketoprofen
Origin:
EU

Keral (Dexketoprofen)

Dexketoprofen, the active ingredient in Keral, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It is indicated for the relief of mild to moderate pain, post‑operative pain and musculoskeletal pain in adult patients.
GNH India supplies Keral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Dexketoprofen acts as an NSAID to manage pain and inflammation in several clinical settings.
  • Mild to moderate pain: provides rapid analgesia for acute pain conditions.
  • Post‑operative pain: reduces discomfort following surgical procedures.
  • Musculoskeletal pain: alleviates pain associated with muscle and joint disorders.

How It Works

  • Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis leads to decreased inflammation, pain signaling, and fever response at the site of tissue injury.

Side Effects

Adverse reactions may occur with dexketoprofen use and are categorized by frequency.

Common Side Effects

  • Nausea
  • Dizziness
  • Headache
  • Injection‑site pain or erythema
  • Dyspepsia
  • Somnolence

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Gastrointestinal bleeding or ulcer perforation
  • Hepatic dysfunction or elevated liver enzymes
  • Acute renal impairment
  • Cardiovascular events such as myocardial infarction or stroke

Precautions & Warnings

  • Before prescribing dexketoprofen, clinicians should consider several safety aspects.
  • Assess renal function: adjust use in patients with renal impairment.
  • Monitor gastrointestinal risk: avoid in patients with active ulcers or bleeding.
  • Avoid in known hypersensitivity: contraindicated for individuals allergic to dexketoprofen or other NSAIDs.
  • Use caution in cardiovascular disease: evaluate thrombotic risk.
  • Pregnancy and lactation: use only if clearly needed after risk assessment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Dexketoprofen may interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.
  • Lithium: NSAIDs may raise lithium serum concentrations.
  • Methotrexate: reduced renal clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: possible decline in renal function.
  • Diuretics: risk of renal impairment when combined.
  • Corticosteroids: increased risk of gastrointestinal ulceration.

Frequently Asked Questions

Keral is a dexketoprofen injectable indicated for the short‑term relief of mild to moderate acute pain, including post‑operative pain and musculoskeletal pain such as that arising from strains, sprains, or inflammatory joint conditions.

Dexketoprofen works by non‑selectively inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels diminish inflammation and interrupt pain signaling pathways, providing analgesic and anti‑inflammatory effects.

The dosage of Keral is determined by the prescribing clinician based on the patient’s condition, severity of pain, and clinical response. The prescriber will select the appropriate strength, route (intramuscular or intravenous), and frequency according to established medical guidelines.

Safety of dexketoprofen in pregnancy and lactation has not been fully established. It should only be used when the potential benefit justifies the possible risk to the fetus or infant, and only after consultation with a qualified healthcare professional.

To order Keral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed) and required import documentation.

Dexketoprofen is the active enantiomer of ketoprofen, offering rapid analgesia with a potentially lower gastrointestinal side‑effect profile at equivalent doses. Compared with non‑selective NSAIDs such as ibuprofen, dexketoprofen may provide faster pain relief, but the overall safety considerations regarding renal, cardiovascular and bleeding risks remain similar.

Keral must be stored at 2‑8 °C in a refrigerator, protected from light. The product should not be frozen or shaken. Keep the vial in its original packaging until use to maintain sterility and potency.

Keral is administered by a qualified healthcare professional via intramuscular or intravenous injection. The route, volume, and rate of injection are selected according to the clinical situation and the prescribing information.

Serious risks include severe allergic reactions such as anaphylaxis, life‑threatening gastrointestinal bleeding or ulcer perforation, hepatic injury, acute renal failure, and cardiovascular events like myocardial infarction or stroke. Patients should be monitored for any signs of these conditions, especially if they have pre‑existing risk factors.

Keral should be avoided in individuals with known hypersensitivity to dexketoprofen or any NSAID, those with active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and in patients for whom NSAIDs are contraindicated due to cardiovascular risk. Use in pregnancy and lactation is only permissible when clearly justified.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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