Keral (Dexketoprofen)

Dexketoprofen is an NSAID that targets pain and inflammation pathways in various clinical settings.

• Pain: delivers rapid analgesic relief for acute nociceptive pain.
• Postoperative pain: reduces pain intensity after surgical procedures.
• Musculoskeletal pain: alleviates discomfort associated with sprains, strains, and soft‑tissue injuries.
• Inflammation: diminishes localized inflammatory responses in acute conditions.

• Dexketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, leading to reduced synthesis of prostaglandins that mediate pain, fever, and inflammation. By blocking these pathways, the drug diminishes peripheral sensitization of nociceptors and limits the inflammatory cascade, resulting in analgesic and anti‑inflammatory effects.

Dexketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Injection site reactions: erythema, swelling, or pain.
• Transient increase in blood pressure.
• Mild renal function changes.

Serious or Rare Side Effects

• Severe gastrointestinal bleeding or ulceration.
• Anaphylactic or severe hypersensitivity reactions.
• Hepatotoxicity: elevated liver enzymes.
• Renal impairment or failure.
• Cardiovascular events: myocardial infarction or stroke.
• Hematologic abnormalities: thrombocytopenia or leukopenia.

When using Dexketoprofen injection, consider the following safety measures.

• Assess renal function: avoid use in patients with severe renal impairment.
• Evaluate gastrointestinal risk: use cautiously in individuals with a history of ulcers or bleeding.
• Monitor cardiovascular status: be vigilant in patients with hypertension or heart disease.
• Check for hypersensitivity: discontinue if signs of allergic reaction appear.
• Avoid concurrent NSAIDs: increase risk of adverse effects.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Dexketoprofen may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
• High‑dose corticosteroids: increased ulcer risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: may enhance nephrotoxic potential.
• Lithium: NSAIDs can raise lithium serum levels.
• Methotrexate: reduced clearance leading to toxicity.