Product image of Keral (Dexketoprofen) supplied by GNH India

Keral

Active Ingredient:
Dexketoprofen
Origin:
EU

Keral (Dexketoprofen)

Dexketoprofen, the active ingredient in Keral, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It is indicated for mild to moderate pain, musculoskeletal pain, post‑operative pain and dysmenorrhea in adult patients.
GNH India supplies Keral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Dexketoprofen acts as an NSAID to relieve pain and inflammation in several common conditions.

  • Mild to moderate pain: provides rapid analgesia for everyday pain.
  • Musculoskeletal pain: reduces discomfort from strains, sprains and arthritis.
  • Post‑operative pain: helps control pain after surgical procedures.
  • Dysmenorrhea: alleviates menstrual cramps and associated discomfort.

How It Works

  • Dexketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which reduces the synthesis of prostaglandins responsible for inflammation, pain and fever. By lowering prostaglandin levels at the site of injury or inflammation, the drug diminishes peripheral sensitisation and provides analgesic and anti‑inflammatory effects.

Side Effects

Dexketoprofen may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: occasional feeling of sickness.
  • Dyspepsia: upset stomach or indigestion.
  • Headache: mild to moderate head pain.
  • Dizziness: transient light‑headedness.
  • Abdominal pain: discomfort in the stomach area.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially severe stomach bleeding.
  • Cardiovascular events: increased risk of heart attack or stroke.
  • Renal impairment: reduced kidney function.
  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Hepatic dysfunction: liver enzyme abnormalities.
  • Anaphylaxis: life‑threatening allergic reaction.

Precautions & Warnings

When prescribing or dispensing Dexketoprofen, consider the following safety measures.

  • Assess renal function: adjust use in patients with kidney impairment.
  • Assess hepatic function: caution in liver disease.
  • Avoid in known hypersensitivity: do not use if the patient is allergic to NSAIDs.
  • Use with caution in the elderly: higher risk of gastrointestinal complications.
  • Monitor cardiovascular risk: avoid in uncontrolled hypertension or known heart disease.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Dexketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal function.
  • Methotrexate: decreased clearance leading to toxicity.

Frequently Asked Questions

Keral contains dexketoprofen, an NSAID indicated for the relief of mild to moderate pain, including musculoskeletal pain, post‑operative discomfort and dysmenorrhea. It works to reduce inflammation and provide analgesia in adult patients.

Dexketoprofen blocks cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which lowers the production of prostaglandins. Reduced prostaglandin levels diminish inflammation, pain signalling and fever, resulting in faster analgesic and anti‑inflammatory effects.

The appropriate dose of Keral is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and response. Dosage instructions should always follow the prescriber’s recommendation and local labeling.

Safety of dexketoprofen in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk, and a healthcare provider should be consulted before use in these situations.

To order Keral, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Dexketoprofen is the active enantiomer of ketoprofen and offers a rapid onset of analgesia, often within 30 minutes. Compared with some traditional NSAIDs, it may provide effective pain relief at lower doses, but the safety profile regarding gastrointestinal and cardiovascular risks remains similar to other NSAIDs.

Keral should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Keral is taken orally, usually with a glass of water. It can be taken with or without food, but if gastrointestinal upset occurs, it may be helpful to take it with a meal. Follow the prescriber’s instructions regarding timing and frequency.

Serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, renal impairment, severe skin reactions, hepatic dysfunction and anaphylaxis. Patients should be monitored for these events, especially if they have pre‑existing risk factors.

Keral should be avoided in patients with known hypersensitivity to dexketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe heart failure, uncontrolled hypertension, and in those with severe renal or hepatic impairment unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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