Product image of Keral (Dexketoprofen) supplied by GNH India

Keral

Active Ingredient:
Dexketoprofen
Origin:
EU

Keral (Dexketoprofen)

Dexketoprofen, the active ingredient in Keral, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for systemic use. It is indicated for the relief of mild to moderate pain, including musculoskeletal discomfort, postoperative pain and dysmenorrhea, and is used in adult patients requiring rapid analgesia.

GNH India supplies Keral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for global distribution.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Dexketoprofen is an NSAID that reduces pain and inflammation by inhibiting cyclooxygenase enzymes.

  • Mild to moderate pain: provides rapid analgesic relief for general pain conditions.
  • Musculoskeletal pain: alleviates pain associated with strains, sprains and arthritis.
  • Postoperative pain: helps control pain after surgical procedures.
  • Dysmenorrhea: reduces menstrual cramps and associated discomfort.

How It Works

  • Dexketoprofen reversibly inhibits both COX‑1 and COX‑2 enzymes, leading to decreased synthesis of prostaglandins that mediate inflammation, pain and fever. By lowering prostaglandin levels at the site of injury, it diminishes peripheral sensitisation of nociceptors and reduces the inflammatory response, resulting in analgesic and anti‑inflammatory effects.

Side Effects

Dexketoprofen may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia.
  • Nausea or vomiting.
  • Headache.
  • Dizziness.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or worsening of chronic kidney disease.
  • Severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before prescribing Dexketoprofen, clinicians should consider several safety factors.

  • Assess renal function: evaluate kidney health prior to initiation.
  • Monitor gastrointestinal risk: avoid in patients with a history of ulcers or bleeding.
  • Avoid concomitant NSAIDs: combined use increases risk of adverse events.
  • Use lowest effective dose: limit duration to the shortest necessary period.
  • Store at ambient temperature: keep below 25 °C, in the original pack, protected from moisture.

Avoid Interactions

Dexketoprofen can interact with several drug classes, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Selective COX‑2 inhibitors: additive renal and cardiovascular toxicity.
  • Corticosteroids: increased gastrointestinal ulcer risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Lithium: NSAIDs may raise lithium serum levels.
  • Methotrexate: reduced clearance may cause toxicity.

Frequently Asked Questions

Keral contains dexketoprofen, an NSAID that is used to relieve mild to moderate pain such as musculoskeletal aches, postoperative discomfort and menstrual cramps. It provides rapid analgesia by reducing inflammation at the source of pain.

Dexketoprofen works by reversibly blocking both COX‑1 and COX‑2 enzymes, which are responsible for producing prostaglandins. Lower prostaglandin levels diminish inflammation, pain signalling and fever, resulting in an overall analgesic and anti‑inflammatory effect.

The appropriate dose of Keral is determined by the prescribing healthcare professional based on the patient’s condition, age, weight and overall health. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for dexketoprofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Keral, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Both Keral (dexketoprofen) and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Dexketoprofen is the active enantiomer of ketoprofen and often provides faster pain relief at lower doses, whereas ibuprofen is widely used with a longer history of generic availability.

Keral should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Keral is taken orally, usually with a glass of water. It can be taken with or without food, but taking it with food may reduce occasional stomach irritation. Patients should follow the dosing schedule prescribed by their clinician.

Serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, and severe allergic reactions such as anaphylaxis or skin disorders like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of bleeding, sudden kidney problems or severe rash.

Keral should be avoided in individuals with known hypersensitivity to dexketoprofen or other NSAIDs, active gastrointestinal ulcer disease, severe heart failure, uncontrolled hypertension, or significant renal impairment. It is also contraindicated in patients receiving certain anticoagulants or other NSAIDs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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