Keratosis + Tretinoin (Tretinoin, Urea)

Tretinoin is a retinoic‑acid analogue that binds to nuclear retinoic acid receptors (RAR‑α, RAR‑β, RAR‑γ). Activation of these receptors modulates gene expression, leading to reduced keratinocyte proliferation and increased differentiation. This accelerates desquamation of hyperkeratotic cells, allowing the skin to shed more regularly and appear smoother.

The appropriate dose and frequency are determined by the prescribing healthcare professional based on the patient’s condition, severity, and skin tolerance. Typically, a thin layer is applied to the affected area once daily or as directed, but exact instructions should always follow the prescriber’s order.

Safety data for topical tretinoin and urea in pregnancy and lactation are limited. The product should be avoided during pregnancy unless the potential benefit justifies the risk, and caution is advised while breastfeeding. Patients should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with single‑agent keratolytics such as salicylic acid, the combination of tretinoin and urea offers both retinoid‑driven normalization of epidermal turnover and urea‑mediated hydration and softening. This dual action can provide faster plaque reduction and improved tolerability, though individual response varies and some patients may prefer simpler formulations.

Store the product at ambient temperature, preferably below 25 °C (77 °F). Keep it in the original container, protected from moisture, light, and excessive heat. Ensure the cap is tightly closed to maintain stability and prevent contamination.

The medication is applied topically to clean, dry skin. A thin, even layer should be spread over the affected area, avoiding contact with eyes, mucous membranes, or broken skin unless directed by a clinician. Wash hands after application and follow any additional instructions from the prescriber.

Serious risks include severe dermatitis or allergic contact dermatitis, which may present as extensive redness, swelling, or blistering, and photosensitivity leading to exaggerated sunburn. If any of these occur, discontinue use and seek medical attention promptly.

Patients with known hypersensitivity to tretinoin, urea, or any excipients in the formulation should avoid the product. It is also contraindicated in individuals with active eczema, severe skin irritation, or those using other topical retinoids without medical supervision.