Product image of Kerberan (Clopidogrel) supplied by GNH India

Kerberan

Active Ingredient:
Clopidogrel
Origin:
EU

Kerberan (Clopidogrel)

Clopidogrel, the active ingredient in Kerberan, is a P2Y12 receptor antagonist (antiplatelet agent) presented as an oral tablet for oral use. It is indicated for the prevention of atherothrombotic events in patients who have experienced recent myocardial infarction, stroke, or who have established peripheral arterial disease, and for secondary prevention after acute coronary syndrome.

GNH India supplies Kerberan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

Kerberan belongs to the antiplatelet drug class and is used to reduce thrombotic risk in several cardiovascular conditions.

  • Myocardial infarction: lowers the chance of recurrent atherothrombotic events after a recent heart attack.
  • Ischemic stroke: helps prevent subsequent strokes in patients with a prior cerebrovascular event.
  • Peripheral arterial disease: reduces limb‑related thrombotic complications in patients with established disease.
  • Acute coronary syndrome: provides secondary prevention of cardiovascular events following unstable angina or non‑ST‑segment elevation myocardial infarction.

How It Works

  • Clopidogrel is an irreversible antagonist of the platelet P2Y12 ADP receptor. By blocking this receptor, it prevents ADP‑mediated activation of the GPIIb/IIIa complex, thereby inhibiting platelet aggregation and reducing thrombus formation in arterial circulation.

Side Effects

Kerberan may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Bleeding gums or easy bruising
  • Diarrhea or abdominal discomfort
  • Nausea or vomiting
  • Headache or dizziness

Serious or Rare Side Effects

  • Severe or uncontrolled bleeding
  • Thrombotic thrombocytopenic purpura (TTP)
  • Hepatic dysfunction or jaundice

Precautions & Warnings

Before prescribing Kerberan, clinicians should evaluate individual risk factors and monitor patients appropriately.

  • Assess bleeding risk: review history of hemorrhage, surgery, or anticoagulant use.
  • Monitor platelet function: consider testing in patients with suspected resistance.
  • Adjust for hepatic impairment: use caution in patients with liver disease.
  • Avoid in active pathological bleeding: discontinue if severe bleeding occurs.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Kerberan can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • CYP2C19 inhibitors (e.g., omeprazole): may reduce antiplatelet effect.
  • Strong CYP3A4 inducers (e.g., rifampin): may lower plasma concentrations.
  • Concurrent anticoagulants (e.g., warfarin, heparin): increase risk of major bleeding.

Moderate Interactions (Monitor Closely)

  • NSAIDs or aspirin: may exacerbate gastrointestinal bleeding.
  • SSRIs or SNRIs: can increase bleeding tendency.
  • Proton pump inhibitors (e.g., esomeprazole): may modestly affect clopidogrel activation.

Frequently Asked Questions

Kerberan contains clopidogrel, an antiplatelet medication used to lower the risk of atherothrombotic events such as heart attack, ischemic stroke, and limb complications in patients with peripheral arterial disease. It is also employed for secondary prevention after acute coronary syndrome.

Clopidogrel irreversibly blocks the platelet P2Y12 ADP receptor, preventing ADP‑driven activation of the GPIIb/IIIa complex. This inhibition stops platelets from aggregating, thereby reducing the formation of arterial clots that can cause heart attacks or strokes.

The dose of Kerberan is individualized by the prescribing clinician based on the patient’s clinical condition, renal function, and concomitant therapies. Healthcare providers determine the appropriate strength and frequency according to current treatment guidelines.

Safety data for clopidogrel in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Kerberan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kerberan (clopidogrel) is a thienopyridine that provides irreversible P2Y12 inhibition, whereas agents like ticagrelor offer reversible inhibition and a faster onset. Choice of therapy depends on patient risk profile, drug‑drug interaction potential, and clinician preference.

Kerberan tablets should be stored at ambient temperature below 25 °C, in the original container, protected from moisture and direct light. Keep out of reach of children and do not use if the packaging is damaged.

Kerberan is taken orally, usually with or without food, as directed by a healthcare professional. The tablet should be swallowed whole with water and not crushed or chewed unless specifically instructed.

The most serious risks associated with Kerberan include severe or uncontrolled bleeding, thrombotic thrombocytopenic purpura (TTP), and rare hepatic dysfunction. Patients should seek immediate medical attention if they experience unusual bruising, blood in stool or urine, or signs of liver injury.

Kerberan is contraindicated in patients with active pathological bleeding, known hypersensitivity to clopidogrel or any component of the formulation, and in those with severe hepatic impairment. Clinicians should also avoid use in patients taking certain strong CYP2C19 inhibitors without careful assessment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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