Product image of Kerizet (Desogestrel) supplied by GNH India

Kerizet

Active Ingredient:
Desogestrel
Origin:
EU

Kerizet (Desogestrel)

Desogestrel, the active ingredient in Kerizet, is a synthetic progestin presented as an oral tablet for systemic use. It is classified as a hormonal contraceptive and works to prevent pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus. The medication is administered orally and is intended for regular daily intake as part of a combined contraceptive regimen.

GNH India supplies Kerizet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements.

Manufacturer / TM Owner

Kern Pharma, S.L.

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Indications & Clinical Uses

Desogestrel is a progestin used in hormonal contraception to prevent pregnancy.

  • Prevention of pregnancy: inhibits ovulation and creates cervical mucus changes that prevent fertilization.
  • Hormonal birth control regimen: serves as the progestin component in combined oral contraceptives for effective contraception.
  • Family planning: provides a reliable method for women seeking long‑term pregnancy prevention.

How It Works

  • Desogestrel binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge and thereby inhibiting ovulation. It also induces changes in cervical mucus, making it less permeable to sperm, and alters the endometrium to reduce the likelihood of implantation.

Side Effects

Desogestrel may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: occasional tension‑type headaches.
  • Breast tenderness: transient discomfort.
  • Irregular bleeding: spotting or changes in menstrual flow.

Serious or Rare Side Effects

  • Deep vein thrombosis (DVT): blood clot formation in deep veins.
  • Severe allergic reaction (anaphylaxis): rapid onset of hives, swelling, and breathing difficulty.

Precautions & Warnings

When prescribing Desogestrel, consider the following precautions.

  • Pregnancy contraindication: not to be used during pregnancy (Category X).
  • Smoking and cardiovascular risk: avoid in women over 35 who smoke due to increased thrombotic risk.
  • Liver disease: use with caution in patients with hepatic impairment.
  • History of thromboembolism: contraindicated in women with prior DVT or pulmonary embolism.
  • Drug interactions: review concomitant medications for CYP3A4 inducers or inhibitors.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Desogestrel may interact with other medicines; monitor accordingly.

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampicin, carbamazepine): may reduce contraceptive efficacy.
  • Antifungal azoles (e.g., ketoconazole): may increase plasma levels of desogestrel.
  • Protease inhibitors (e.g., ritonavir): may alter hormone concentrations.

Moderate Interactions (Monitor Closely)

  • SSRIs (selective serotonin reuptake inhibitors): may increase risk of mood changes.
  • Macrolide antibiotics (e.g., erythromycin): may modestly affect contraceptive effectiveness.
  • St. John’s wort: herbal supplement that may reduce hormonal efficacy.

Frequently Asked Questions

Kerizet contains desogestrel, a synthetic progestin that is prescribed as a hormonal contraceptive to prevent pregnancy in women of reproductive age. It works as part of a combined oral contraceptive regimen to inhibit ovulation and create cervical mucus that is hostile to sperm.

Desogestrel binds to progesterone receptors in the brain, suppressing the luteinizing hormone surge that triggers ovulation. It also thickens cervical mucus, reducing sperm penetration, and alters the endometrial lining, making implantation of a fertilized egg unlikely.

The specific dosing schedule for Kerizet is determined by the prescribing healthcare professional based on individual patient needs and local guidelines. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Kerizet is classified as pregnancy category X, meaning it must not be used during pregnancy because it can cause harm to the fetus. It is also not recommended while breastfeeding, as desogestrel may be excreted in breast milk and affect the infant.

To order Kerizet, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kerizet’s active ingredient, desogestrel, is a third‑generation progestin that offers a lower risk of androgenic side effects compared with earlier progestins. It provides comparable contraceptive efficacy to other combined oral contraceptives while often being better tolerated in terms of skin and weight‑related effects.

Kerizet tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Kerizet is taken orally, usually once daily at the same time each day as part of a combined oral contraceptive regimen. The tablet is swallowed whole with water and should be taken with or without food as directed by the prescriber.

Serious risks include thromboembolic events such as deep vein thrombosis or pulmonary embolism, especially in women who smoke, are over 35, or have a history of clotting disorders. Rarely, severe allergic reactions can occur, requiring immediate medical attention.

Kerizet should not be used by women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic disease, severe liver disease, or who are smokers over the age of 35. It is also contraindicated in individuals with known hypersensitivity to desogestrel or any tablet excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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