Product image of Keronac (Diclofenac Sodium) supplied by GNH India

Keronac

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Keronac (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Keronac, is a nonsteroidal anti-inflammatory drug presented as a topical gel for cutaneous use. It reduces pain and inflammation in musculoskeletal conditions.

GNH India supplies Keronac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Klinge Pharma Gmbh

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Indications & Clinical Uses

Diclofenac sodium is used to manage pain and inflammation in musculoskeletal disorders.

  • Osteoarthritis of the knee: relief of joint pain and reduction of inflammation.
  • Acute muscle sprain: alleviation of localized pain and swelling.
  • Tendinitis: decrease in tendon inflammation and associated discomfort.
  • Bursitis: mitigation of bursae swelling and pain.
  • Low back pain: short‑term reduction of lumbar discomfort.

How It Works

  • Diclofenac sodium inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it reduces the inflammatory cascade, leading to decreased pain signaling and edema at the site of application.

Side Effects

Topical diclofenac can cause a range of skin‑related and systemic reactions.

Common Side Effects

  • Skin irritation: mild redness or discomfort at the application site.
  • Burning sensation: transient warmth or stinging after use.
  • Itching: localized pruritus.
  • Dry skin: occasional flaking or dryness.
  • Rash: mild erythematous eruption.
  • Photosensitivity: increased sensitivity to sunlight.

Serious or Rare Side Effects

  • Severe allergic reactions: angioedema, anaphylaxis, or Stevens‑Johnson syndrome.
  • Liver toxicity: elevated liver enzymes or hepatitis.
  • Cardiovascular events: increased risk of thrombotic events.
  • Gastrointestinal ulceration: rare systemic ulcer formation.
  • Severe skin reactions: necrotizing fasciitis or bullous dermatitis.
  • Systemic toxicity: renal impairment or hematologic abnormalities.

Precautions & Warnings

When using Keronac, consider the following safety measures.

  • Avoid use on infected or broken skin: may worsen infection.
  • Do not apply to open wounds: risk of systemic absorption.
  • Limit application area: adhere to prescribed surface size.
  • Review anticoagulant therapy: increased bleeding potential.
  • Pregnancy and breastfeeding: discuss risks with a healthcare professional.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Diclofenac sodium may interact with several drug classes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • Lithium: possible increase in serum lithium levels.
  • Methotrexate: enhanced methotrexate toxicity.
  • Selective COX‑2 inhibitors: combined cardiovascular risk.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors: potential renal function changes.

  • Diuretics: possible reduction in antihypertensive effect.
  • Corticosteroids: increased risk of ulceration.
  • SSRIs: additive bleeding tendency.

Frequently Asked Questions

Keronac is a topical formulation containing diclofenac sodium that is applied to the skin to relieve pain and reduce inflammation associated with musculoskeletal conditions such as osteoarthritis, sprains, tendonitis, bursitis, and low back pain.

Diclofenac sodium blocks the cyclooxygenase (COX) enzymes responsible for producing prostaglandins, which are mediators of inflammation and pain. By reducing prostaglandin synthesis, the drug diminishes local inflammation and the perception of pain at the site of application.

The appropriate amount of Keronac to apply is determined by the prescribing healthcare professional based on the specific condition, treatment area, and patient factors. Patients should follow the prescriber’s instructions and not exceed the recommended quantity.

Safety of topical diclofenac during pregnancy or lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Keronac.

To request Keronac, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Keronac delivers diclofenac directly to the skin, providing targeted pain relief with lower systemic exposure compared with oral NSAIDs. This can reduce the risk of gastrointestinal side effects, but local skin reactions may be more common. Choice of therapy depends on the clinical situation and patient tolerance.

Store Keronac at room temperature, preferably below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and keep it out of reach of children.

Keronac is applied topically to clean, dry skin. A thin layer is spread over the affected area, usually 2–4 g depending on the size of the region, and gently massaged until absorbed. Hands should be washed after application unless treating the hands themselves.

Serious risks include severe allergic reactions such as angioedema or Stevens‑Johnson syndrome, liver toxicity, cardiovascular events, and rare systemic gastrointestinal ulceration. Patients should seek immediate medical attention if they notice signs of a serious reaction.

Keronac should be avoided in individuals with known hypersensitivity to diclofenac or other NSAIDs, those with active skin infections at the intended site, and patients with severe hepatic, renal, or cardiovascular disease unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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