Product image of Kestine (Ebastine) supplied by GNH India

Kestine

Active Ingredient:
Ebastine
Origin:
EU

Kestine (Ebastine)

Ebastine, the active ingredient in Kestine, is a second‑generation H1 antihistamine presented as an oral dosage form for oral use. It is indicated for the treatment of allergic rhinitis and chronic idiopathic urticaria in patients requiring relief from histamine‑mediated symptoms.

GNH India supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Almirall, S.A.

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Indications & Clinical Uses

Ebastine acts on the histamine‑H1 pathway to alleviate allergic conditions.

  • Allergic rhinitis: reduces nasal congestion, sneezing and itching caused by seasonal or perennial allergens.
  • Chronic idiopathic urticaria: diminishes the frequency and severity of hives and associated itching.
  • Allergic skin itching: provides symptomatic relief of itching due to allergic reactions.

How It Works

  • Ebastine selectively blocks peripheral H1 receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor, the drug reduces the classic signs of allergic inflammation without significant central nervous system penetration.

Side Effects

Adverse reactions may occur with ebastine therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Drowsiness: occasional sedation, especially at higher doses.
  • Dry mouth: reduced salivation.
  • Nausea: transient gastrointestinal discomfort.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat requiring urgent care.
  • Severe rash or Stevens‑Johnson syndrome: extensive skin involvement.
  • Hepatitis: elevated liver enzymes or jaundice.
  • Anaphylaxis: rapid onset of systemic allergic reaction.
  • Cardiac arrhythmia: rare but reported in susceptible individuals.

Precautions & Warnings

Before initiating ebastine, consider the following precautions.

  • Assess hepatic function: adjust use in patients with liver impairment.
  • Avoid in patients with known hypersensitivity to ebastine or other antihistamines.
  • Caution in renal impairment: monitor renal function periodically.
  • Monitor for sedation: advise patients not to operate machinery if drowsy.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ebastine may interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Ketoconazole: can increase ebastine plasma concentrations.
  • Ritonavir: may elevate ebastine levels, raising risk of side effects.
  • Erythromycin: potential to raise systemic exposure.

Moderate Interactions (Monitor Closely)

  • Theophylline: may reduce its bronchodilator effect.
  • Alcohol: can enhance drowsiness.
  • Other antihistamines: additive sedation may occur.

Frequently Asked Questions

Kestine contains ebastine, which is prescribed to manage allergic rhinitis and chronic idiopathic urticaria. It helps relieve nasal congestion, sneezing, itching, and reduces the frequency and severity of hives in patients with these allergic disorders.

Ebastine works by selectively blocking peripheral H1 histamine receptors. This prevents histamine from triggering the inflammatory cascade that causes vasodilation, increased vascular permeability, and nerve irritation, thereby reducing typical allergy signs such as itching, swelling, and nasal discharge.

The dosage of Kestine is determined by the prescribing healthcare professional based on the patient’s age, condition severity, and overall health. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

The safety of ebastine in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks before prescribing Kestine to pregnant or nursing mothers.

To request Kestine, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kestine (ebastine) is a second‑generation H1 antihistamine, offering effective allergy relief with a lower propensity for sedation compared with first‑generation agents. Its once‑daily dosing and selective peripheral action make it a convenient alternative to other second‑generation antihistamines such as cetirizine or loratadine.

Kestine should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and direct sunlight to maintain potency throughout the shelf life.

Kestine is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber.

Serious adverse events, though rare, include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, hepatitis, anaphylaxis, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience swelling of the face or throat, widespread rash, or any signs of an allergic emergency.

Kestine should be avoided in individuals with known hypersensitivity to ebastine or other H1 antihistamines. Caution is also advised for patients with severe liver or kidney impairment, and it is not recommended for use in children under the age specified by the prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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