Kestine (Ebastine)

Ebastine acts as a selective peripheral H1‑receptor antagonist. By binding to H1 receptors on mast cells, basophils and other target tissues, it blocks the action of histamine released during allergic reactions, thereby preventing the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation responsible for typical allergy symptoms.

The dosage of ebastine is determined by the prescribing clinician based on the patient’s age, severity of symptoms and any relevant comorbidities. In most adult cases, a single oral dose is administered once daily, but the exact amount and frequency must be specified on the prescription. Patients should follow the healthcare professional’s instructions precisely.

Safety data for ebastine during pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. Consequently, it should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Breastfeeding mothers should consult their physician before initiating therapy.

To place an order, submit an enquiry on the Kestine product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation antihistamines, ebastine causes less sedation because it does not readily cross the blood‑brain barrier. Within the second‑generation class, its efficacy in relieving allergic rhinitis and chronic urticaria is comparable to agents such as cetirizine or loratadine, while offering a favorable safety profile and once‑daily dosing for many patients.

Kestine should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and keep them out of reach of children. Do not store in a refrigerator or freezer unless specifically instructed by the supplier.

Kestine is taken orally, usually as a whole tablet with a glass of water. It may be taken with or without food, but patients should avoid crushing or chewing the tablet to ensure proper absorption. The medication is intended for once‑daily use, and the exact timing should follow the prescriber’s guidance.

Although uncommon, serious adverse reactions can occur, including angioedema, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, cardiac arrhythmias, significant liver enzyme elevations and blood dyscrasias. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, difficulty breathing, or unexplained fatigue.

Kestine is contraindicated in individuals with known hypersensitivity to ebastine or any of the tablet excipients. Caution is also advised for patients with severe hepatic impairment, as metabolism may be affected. Pregnant or nursing women should only use the drug when clearly indicated, and it should be avoided in patients taking strong CYP3A4 inhibitors unless supervised by a physician.