Product image of Kestine (Ebastine) supplied by GNH India

Kestine

Active Ingredient:
Ebastine
Origin:
EU

Kestine (Ebastine)

Ebastine, the active ingredient in Kestine, is a second‑generation H1‑receptor antagonist presented as a 10 mg oral tablet for oral use. It is used to treat allergic rhinitis and chronic idiopathic urticaria in adults and adolescents, providing relief from nasal congestion, itching, sneezing, and hives.

GNH India supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and ensures batch consistency for global distribution.

Manufacturer / TM Owner

Almirall, S.A.

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Indications & Clinical Uses

  • Ebastine is indicated for allergic conditions that involve histamine‑mediated responses.
  • Allergic rhinitis: alleviates nasal congestion, sneezing, itching and rhinorrhea.
  • Chronic idiopathic urticaria: reduces frequency and severity of wheals and itching.
  • Seasonal allergic rhinitis: provides symptom control during pollen exposure.

How It Works

  • Ebastine selectively blocks peripheral H1 histamine receptors, preventing histamine from binding to mast cells and basophils. This inhibition reduces vascular permeability, smooth‑muscle contraction, and sensory nerve activation, thereby diminishing the classic signs of allergic inflammation such as itching, swelling, and mucus production.

Side Effects

Like all antihistamines, Ebastine may cause adverse reactions, which are generally mild but can be serious in rare cases.

Common Side Effects

  • Headache
  • Dry mouth
  • Drowsiness
  • Fatigue
  • Gastrointestinal discomfort
  • Dizziness

Serious or Rare Side Effects

  • Angioedema
  • Severe skin rash (e.g., Stevens‑Johnson syndrome)
  • Anaphylactic reaction
  • Cardiac arrhythmia
  • Hepatotoxicity
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

  • Before prescribing Ebastine, clinicians should consider several safety aspects.
  • Hepatic function: assess liver status prior to initiation.
  • Renal impairment: use with caution and consider dose adjustment.
  • Known hypersensitivity: avoid in patients allergic to ebastine or excipients.
  • Pregnancy: consult a healthcare provider before use.
  • Breastfeeding: weigh potential risks and benefits.
  • Elderly: start at the lowest effective dose and monitor closely.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Ebastine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Ketoconazole: may increase plasma ebastine concentrations.
  • Erythromycin: can raise ebastine levels and enhance side effects.
  • Ritonavir: may significantly elevate ebastine exposure.

Moderate Interactions (Monitor Closely):\n- Theophylline: possible increase in theophylline side effects.

  • Alcohol: may enhance drowsiness and sedation.
  • Other antihistamines: additive sedative effects may occur.

Frequently Asked Questions

Kestine contains ebastine, which is prescribed for allergic rhinitis and chronic idiopathic urticaria. In these conditions it helps relieve nasal congestion, sneezing, itching, and hives by blocking the action of histamine.

Ebastine is a selective peripheral H1‑receptor antagonist. By binding to H1 receptors on mast cells and other tissues, it prevents histamine from triggering the cascade that leads to allergy symptoms such as swelling, itching, and mucus production.

The specific dose of Kestine is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical judgment. Dosage information is provided on the prescription label.

Safety data for ebastine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Kestine.

To place an order, submit an enquiry on the Kestine product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kestine (ebastine) is a second‑generation antihistamine, offering effective allergy relief with a lower propensity for sedation compared with first‑generation agents such as diphenhydramine. Its once‑daily dosing and selective H1 blockade make it a convenient option for many patients.

Kestine should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat to maintain product stability.

Kestine is taken orally, usually as a tablet swallowed with water. It is typically taken once daily, but the exact timing and any food considerations should follow the prescribing clinician’s instructions.

While rare, serious adverse reactions can include angioedema, severe skin rashes such as Stevens‑Johnson syndrome, anaphylaxis, cardiac arrhythmias, and liver injury. Patients should seek immediate medical attention if they experience any of these symptoms.

Kestine should be avoided in individuals with known hypersensitivity to ebastine or any tablet excipients. Caution is also advised for patients with severe hepatic impairment, and it should only be used during pregnancy or lactation after a risk‑benefit assessment by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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