Product image of Kestine (Ebastine) supplied by GNH India

Kestine

Active Ingredient:
Ebastine
Origin:
EU

Kestine (Ebastine)

Ebastine, the active ingredient in Kestine, is a second‑generation H1 antihistamine presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents.

GNH India supplies Kestine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Almirall, S.A.

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Indications & Clinical Uses

  • Ebastine is a second‑generation H1 antihistamine used to manage allergic conditions affecting the nasal passages and skin.
  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge.
  • Chronic idiopathic urticaria: alleviates hives, itching and swelling of the skin.

How It Works

  • Ebastine selectively blocks peripheral H1 receptors, preventing histamine from binding to mast cells and basophils. This inhibition reduces histamine‑induced vascular permeability, edema, and pruritus, thereby mitigating the inflammatory response associated with allergic rhinitis and chronic urticaria without significant central nervous system penetration.

Side Effects

Adverse reactions may occur with ebastine therapy.

Common Side Effects

  • Headache
  • Dry mouth
  • Drowsiness
  • Nausea

Serious or Rare Side Effects

  • Angioedema
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Anaphylactic shock

Precautions & Warnings

  • Before prescribing ebastine, consider the following safety measures.
  • Assess hepatic function: evaluate liver enzymes in patients with known liver disease.
  • Monitor for sedation: observe patients who may experience drowsiness, especially when driving.
  • Avoid in known hypersensitivity: discontinue if allergic reactions develop.
  • Caution in the elderly: start at the lowest effective dose and monitor closely.
  • Use with caution in renal impairment: dose adjustment may be required.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Ebastine may interact with other medicines; review patient medication lists.

Major Interactions (Avoid)

  • Ketoconazole: may increase ebastine plasma concentrations.
  • Ritonavir: can markedly raise ebastine levels, raising risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance sedative effects.
  • Other antihistamines: additive antihistaminic activity may increase drowsiness.
  • CNS depressants: monitor for enhanced central sedation.

Frequently Asked Questions

Kestine contains ebastine, a second‑generation H1 antihistamine indicated for the relief of symptoms associated with allergic rhinitis, such as sneezing, nasal itching and congestion, as well as for chronic idiopathic urticaria, helping to reduce hives and itching.

Ebastine works by selectively blocking peripheral H1 histamine receptors. This prevents histamine from triggering the cascade that leads to increased vascular permeability, edema, and itching, thereby reducing the allergic response without significant sedation.

The appropriate dose of Kestine is determined by the prescribing healthcare professional based on the patient’s age, condition severity, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for ebastine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation antihistamines, ebastine (Kestine) offers effective allergy relief with a lower risk of sedation and anticholinergic side effects. It is similar in efficacy to other second‑generation agents such as cetirizine or loratadine, but individual response may vary.

Kestine should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool place helps maintain its stability and potency.

Kestine is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber regarding timing and any food considerations.

While uncommon, serious adverse reactions can include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or difficulty breathing.

Kestine should be avoided in individuals with known hypersensitivity to ebastine or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment, and it should be used only under medical supervision in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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