Product image of Ketalar (Ketamine) supplied by GNH India

Ketalar

Active Ingredient:
Ketamine
Origin:
EU

Ketalar (Ketamine)

Ketamine, the active ingredient in Ketalar, is a dissociative anesthetic presented as a sterile injectable solution for intramuscular and intravenous use. It is employed to induce anesthesia, provide analgesia, and achieve procedural sedation in surgical and diagnostic settings for patients, under controlled medical supervision and monitoring.

GNH India supplies Ketalar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on reliable quality and regulatory compliance. The company ensures timely delivery and supports customers with technical and regulatory assistance.

Manufacturer / TM Owner

Pfizer S.A.

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Indications & Clinical Uses

  • Ketamine is a dissociative anesthetic that acts on the central nervous system via NMDA receptor antagonism, providing rapid loss of consciousness and analgesia.
  • Induction of anesthesia: produces a controlled state of unconsciousness for surgical procedures.
  • Analgesia: delivers potent pain relief during and after operative or diagnostic interventions.
  • Sedation: facilitates procedural sedation for short‑duration examinations or minor surgeries.

How It Works

  • Ketamine blocks the N‑methyl‑D‑aspartate (NMDA) receptor, inhibiting excitatory glutamate transmission in the brain. This antagonism reduces neuronal firing, leading to dissociation, analgesia, and amnesia. Additional actions include stimulation of opioid receptors, inhibition of nitric oxide synthase, and interaction with monoaminergic pathways, which together contribute to its anesthetic and analgesic properties while preserving airway reflexes and cardiovascular stability.

Side Effects

Ketamine may cause a range of adverse reactions, varying from mild to severe, depending on dose and patient factors.

Common Side Effects

  • Dizziness
  • Nausea
  • Vomiting
  • Increased salivation

Serious or Rare Side Effects

  • Respiratory depression
  • Emergence delirium
  • Hallucinations

Precautions & Warnings

  • When using Ketalar, clinicians should observe specific safety measures to minimize risks and ensure optimal patient outcomes.
  • Monitor cardiovascular status: observe blood pressure and heart rate for hypertension or tachycardia.
  • Assess airway patency: ensure airway is protected due to potential loss of reflexes.
  • Avoid use in severe psychiatric disorders: risk of psychotomimetic reactions.
  • Use lowest effective dose: limit exposure to reduce side effects.
  • Adjust dose in hepatic impairment: metabolism may be reduced.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ketamine can interact with other medicines, altering its effects or increasing the risk of adverse events.

Major Interactions (Avoid)

  • Opioids and other central nervous system depressants
  • Monoamine oxidase inhibitors
  • Sympathomimetic agents (e.g., epinephrine)

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs
  • CYP450 substrates (especially CYP2B6 and CYP3A4)
  • Anticholinergic medications

Frequently Asked Questions

Ketalar is a brand name for injectable ketamine, a dissociative anesthetic used to induce general anesthesia, provide analgesia during surgical or diagnostic procedures, and to achieve procedural sedation for short‑duration interventions.

Ketamine works primarily by blocking NMDA receptors in the central nervous system, which reduces excitatory glutamate signaling. This leads to dissociation, analgesia, and amnesia, while also interacting with opioid and monoaminergic pathways to support its anesthetic effects.

The dose of Ketalar is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and the intended procedure. Dosage is individualized and administered by qualified healthcare professionals in a controlled setting.

Safety data for ketamine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Ketalar, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import documentation.

Compared with agents such as propofol, ketamine provides analgesia and maintains cardiovascular stability, but it can cause psychotomimetic effects. Unlike volatile anesthetics, ketamine does not depress respiratory drive as strongly, making it useful in trauma or emergency settings where airway protection is a concern.

Ketalar should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain potency and sterility.

Ketalar is administered by a qualified healthcare professional via intramuscular or intravenous injection. The route, rate of injection and total dose are selected according to the clinical indication and patient monitoring requirements.

Serious risks include respiratory depression, emergence delirium or hallucinations, and cardiovascular effects such as hypertension or tachycardia. Continuous monitoring of airway, breathing, circulation and mental status is essential during and after administration.

Ketalar is contraindicated in patients with known hypersensitivity to ketamine, severe uncontrolled hypertension, or those with a history of severe psychiatric disorders that could be exacerbated by dissociative effects. Caution is also advised in patients with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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