Product image of Ketalar (Ketamine) supplied by GNH India

Ketalar

Active Ingredient:
Ketamine
Origin:
EU

Ketalar (Ketamine)

Ketamine, the active ingredient in Ketalar, is a dissociative anesthetic presented as an injectable solution for intramuscular and intravenous use. It is employed to induce general anesthesia, provide procedural sedation, and deliver analgesia in surgical and diagnostic settings.

GNH India supplies Ketalar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, sourcing the product from EU manufacturers adhering to stringent quality standards. Our distribution network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Pfizer Europe Ma Eeig

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Indications & Clinical Uses

Ketamine acts on the central nervous system to produce dissociative anesthesia and analgesia, making it suitable for several clinical scenarios.

  • Induction of general anesthesia: provides rapid, controllable unconsciousness for surgical procedures.
  • Procedural sedation: offers sedation and analgesia for diagnostic or minor surgical interventions.
  • Analgesia: delivers potent pain relief in peri‑operative settings and for severe acute pain.

How It Works

  • Ketamine is a non‑competitive antagonist of the N‑methyl‑D‑aspartate (NMDA) receptor, blocking excitatory neurotransmission in the brain. This inhibition disrupts pain signal transmission and produces a dissociative state, while also stimulating opioid receptors and increasing sympathetic outflow, which contributes to its anesthetic and analgesic properties.

Side Effects

Ketamine may cause a range of adverse reactions, ranging from mild to severe.

Common Side Effects

  • Hypertension: transient increase in blood pressure.
  • Tachycardia: elevated heart rate.
  • Nausea: feeling of sickness.
  • Vomiting: expulsion of stomach contents.
  • Dizziness: sensation of light‑headedness.
  • Visual disturbances: blurred or altered vision.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort.
  • Laryngospasm: involuntary vocal cord closure.
  • Emergence delirium: agitation and confusion on waking.
  • Hallucinations: vivid sensory distortions.
  • Seizures: abnormal electrical brain activity.
  • Severe allergic reactions: rash, swelling, anaphylaxis.

Precautions & Warnings

Ketamine requires careful patient assessment and monitoring to minimize risks.

  • Cardiovascular monitoring: observe blood pressure and heart rate during administration.
  • Respiratory monitoring: ensure adequate ventilation and oxygenation.
  • Contraindications: avoid use in patients with known hypersensitivity to ketamine.
  • Psychiatric considerations: use cautiously in individuals with schizophrenia or severe mental illness.
  • Drug interactions: review concomitant medications for additive CNS effects.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Ketamine can interact with other agents, altering its safety profile.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines, barbiturates): may enhance sedation and respiratory depression.
  • MAO inhibitors: risk of hypertensive crisis.
  • Sympathomimetic agents (e.g., epinephrine): additive cardiovascular stimulation.

Moderate Interactions (Monitor Closely)

  • Alcohol: increased central nervous system effects.
  • Antihypertensives: possible attenuation of blood pressure control.
  • Anticholinergics: may exacerbate tachycardia.
  • Serotonergic drugs: potential for serotonin syndrome.

Frequently Asked Questions

Ketalar contains ketamine, which is used to induce general anesthesia, provide procedural sedation, and deliver analgesia in surgical, diagnostic, and emergency settings. It is administered by trained healthcare professionals via intramuscular or intravenous routes.

Ketamine blocks the NMDA receptor, a key excitatory pathway in the central nervous system. This inhibition disrupts pain transmission and produces a dissociative anesthetic state, while also stimulating opioid receptors and increasing sympathetic tone, contributing to its analgesic and cardiovascular effects.

The dose of Ketalar is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and the intended procedure. Healthcare providers calculate the appropriate amount and route of administration according to established medical guidelines.

The safety of ketamine in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Ketalar (ketamine) differs from traditional inhalational or opioid anesthetics by providing dissociative anesthesia without significant respiratory depression. It also maintains airway reflexes and stimulates sympathetic output, which can be advantageous in trauma or hemodynamically unstable patients compared with agents that cause hypotension.

Ketalar should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations. Ensure the container is tightly sealed to maintain sterility until use.

Ketalar is administered by a qualified professional via intramuscular or intravenous injection. The route, rate, and total dose are individualized based on the procedure, patient characteristics, and clinical response, with continuous monitoring of vital signs throughout the administration.

Serious risks include respiratory depression, laryngospasm, severe hypertension, emergence delirium, hallucinations, seizures, and rare allergic reactions. Continuous monitoring of airway, breathing, and circulation is essential to detect and manage these events promptly.

Ketalar is contraindicated in patients with known hypersensitivity to ketamine or its excipients. Caution is advised for individuals with severe cardiovascular disease, uncontrolled hypertension, schizophrenia, or other severe psychiatric disorders, and it should be avoided in patients where airway protection cannot be guaranteed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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