Product image of Ketamin Abcur (Ketamine) supplied by GNH India

Ketamin Abcur

Active Ingredient:
Ketamine
Origin:
EU

Ketamin Abcur (Ketamine)

Ketamine, the active ingredient in Ketamin Abcur, is a NMDA receptor antagonist presented as an injectable solution for intramuscular, intravenous use. It provides induction of anesthesia, procedural sedation and analgesia in surgical and diagnostic settings.

GNH India supplies Ketamin Abcur as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Abcur Ab

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Indications & Clinical Uses

Ketamine is an NMDA receptor antagonist used in anesthesia and pain management.

  • Induction of anesthesia: provides rapid loss of consciousness for surgical procedures.
  • Procedural sedation: enables safe sedation for diagnostic or minor surgical procedures.
  • Analgesia: delivers dissociative analgesia for acute pain management.
  • Emergency airway management: facilitates rapid sequence induction when airway control is required.

How It Works

  • Ketamine blocks the N-methyl-D-aspartate (NMDA) receptor channel, reducing excitatory glutamate transmission in the central nervous system. This antagonism leads to dissociative anesthesia, analgesia, and amnesia. Additional actions include stimulation of opioid receptors, inhibition of nitric oxide synthesis, and sympathetic nervous system activation, contributing to its cardiovascular effects and analgesic properties.

Side Effects

Ketamine may cause a range of adverse reactions.

Common Side Effects

  • Hypertension: elevated blood pressure during and after administration.
  • Nausea: feeling of sickness often accompanied by stomach discomfort.
  • Salivation: increased oral secretions that may require anticholinergic management.
  • Dizziness: transient light‑headedness or vertigo.

Serious or Rare Side Effects

  • Emergence reactions (hallucinations): vivid dreams or dysphoric experiences during recovery.
  • Respiratory depression: reduced breathing effort, especially when combined with other depressants.
  • Cardiac arrhythmias: irregular heart rhythms that may require monitoring.

Precautions & Warnings

Ketamine administration requires careful clinical oversight.

  • Monitor cardiovascular status: observe blood pressure and heart rate continuously.
  • Assess airway reflexes: ensure airway protection before and after dosing.
  • Use caution in patients with psychiatric disorders: risk of emergence phenomena.
  • Avoid in patients with uncontrolled hypertension: may exacerbate blood pressure spikes.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Ketamine can interact with several drug classes.

Major Interactions (Avoid)

  • Central nervous system depressants (e.g., benzodiazepines, opioids): additive sedation and respiratory depression.
  • Sympathomimetic agents (e.g., epinephrine): risk of severe hypertension.
  • Monoamine oxidase inhibitors: unpredictable hemodynamic responses.

Moderate Interactions (Monitor Closely)

  • Alcohol: increased sedative effect.
  • Antihypertensive agents: may blunt expected blood pressure changes.
  • Inhalational anesthetics: potential potentiation of cardiovascular effects.

Frequently Asked Questions

Ketamin Abcur contains ketamine, which is employed by clinicians for induction of general anesthesia, procedural sedation during diagnostic or minor surgical procedures, and for providing analgesia in acute pain situations. Its dissociative properties make it valuable in a range of operative and emergency settings.

Ketamine acts primarily as an antagonist of the NMDA receptor, blocking excitatory glutamate signaling in the central nervous system. This blockade produces dissociative anesthesia and analgesia. Additional mechanisms include stimulation of opioid receptors and activation of the sympathetic nervous system, which contribute to its cardiovascular profile.

The dose of Ketamin Abcur is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and the intended use (e.g., induction, sedation, or analgesia). Only a qualified health professional should set the dosing regimen.

Safety data for ketamine in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Use during pregnancy or while breastfeeding should only occur if the potential benefits justify the potential risks, and after thorough evaluation by a healthcare provider.

To request Ketamin Abcur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with traditional inhalational or opioid‑based anesthetics, ketamine provides dissociative anesthesia while preserving airway reflexes and stimulating the sympathetic nervous system, which can maintain blood pressure. It is especially useful in trauma or emergency settings where hemodynamic stability is critical, but it may cause emergence phenomena not seen with many other agents.

Ketamin Abcur should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain its stability and sterility.

Ketamin Abcur is supplied as a sterile injectable solution and can be given intravenously or intramuscularly by a qualified healthcare professional. The route, rate of injection, and total dose are determined by the clinical scenario and the prescriber’s judgment.

Serious risks include emergence reactions such as vivid hallucinations or dysphoria, respiratory depression especially when combined with other depressants, and cardiac arrhythmias or severe hypertension. Patients should be closely monitored for these events, and emergency equipment must be readily available.

Ketamin Abcur is contraindicated in patients with known hypersensitivity to ketamine or any of its excipients, those with uncontrolled hypertension, and individuals with a history of severe psychiatric disorders prone to emergence phenomena. Caution is also advised in patients with cardiovascular disease, elevated intracranial pressure, or compromised airway reflexes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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