Product image of Ketamin, Enthält Benzethoniumchlorid G.L. (Ketamine) supplied by GNH India

Ketamin, Enthält Benzethoniumchlorid G.L.

Active Ingredient:
Ketamine
Origin:
EU

Ketamin, Enthält Benzethoniumchlorid G.L. (Ketamine)

Ketamine, the active ingredient in Ketamin, Enthält Benzethoniumchlorid G.L., is a NMDA receptor antagonist presented as a sterile injectable solution for intramuscular and intravenous use. It provides dissociative anesthesia and analgesia for surgical and procedural settings.
GNH India supplies Ketamin, Enthält Benzethoniumchlorid G.L. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Ketamine acts as an NMDA receptor antagonist used in anesthesia and pain management.

  • Induction of anesthesia: produces rapid loss of consciousness for surgical procedures.
  • Analgesia: provides effective pain relief during and after surgery.
  • Sedation: facilitates procedural sedation and intensive care management.

How It Works

  • Ketamine binds to and blocks the N‑methyl‑D‑aspartate (NMDA) receptor channel, preventing excitatory neurotransmission. This antagonism disrupts synaptic signaling in the central nervous system, leading to dissociative anesthesia, analgesia, and sedation without significant respiratory depression at therapeutic doses.

Side Effects

Ketamine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea
  • Vomiting
  • Dizziness
  • Increased salivation
  • Visual disturbances
  • Hypertension

Serious or Rare Side Effects

  • Respiratory depression
  • Severe hypertension or tachycardia
  • Cardiac arrhythmias
  • Emergence reactions (hallucinations, agitation)
  • Neurotoxicity with high cumulative doses
  • Allergic reactions (rash, anaphylaxis)

Precautions & Warnings

Ketamine requires careful clinical monitoring and specific safety measures.

  • Assess airway: ensure airway protection before administration.
  • Monitor cardiovascular status: observe blood pressure and heart rate continuously.
  • Avoid in uncontrolled hypertension: risk of severe blood pressure spikes.
  • Use with caution in psychiatric disorders: possible emergence phenomena.
  • Avoid concurrent CNS depressants: increased risk of respiratory depression.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ketamine can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • Other NMDA antagonists: additive central nervous system depression.
  • Monoamine oxidase inhibitors: risk of hypertensive crisis.
  • Opioids: profound respiratory depression when combined.

Moderate Interactions (Monitor Closely)

  • Alcohol: enhances sedative effects.
  • Benzodiazepines: increased sedation and respiratory depression.
  • Sympathomimetic agents: may counteract ketamine‑induced blood pressure changes.

Frequently Asked Questions

Ketamin, Enthält Benzethoniumchlorid G.L. contains ketamine, which is used primarily for the induction of anesthesia, procedural sedation, and analgesia in surgical and intensive‑care settings.

Ketamine blocks the NMDA receptor, a key excitatory neurotransmitter pathway in the central nervous system. This antagonism disrupts normal synaptic transmission, producing dissociative anesthesia, analgesia, and sedation while typically preserving airway reflexes.

The dose of ketamine is individualized by the prescribing clinician based on the patient’s age, weight, clinical condition, and route of administration. Healthcare professionals determine the appropriate amount and infusion rate.

Safety data for ketamine in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Ketamine differs from many inhalational or opioid‑based anesthetics by providing dissociative anesthesia without significant respiratory depression. It also offers analgesic properties and maintains cardiovascular stability, making it useful in trauma or emergency settings where other agents may cause hypotension.

Ketamin, Enthält Benzethoniumchlorid G.L. should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain potency.

Ketamine is administered by a qualified healthcare professional via intramuscular injection or intravenous infusion. The route, rate, and total dose are determined by the clinical situation and the prescriber’s judgment.

Serious risks include respiratory depression, severe hypertension or tachycardia, cardiac arrhythmias, emergence reactions such as hallucinations, and rare neurotoxic effects with high cumulative dosing. Continuous monitoring is essential during administration.

Ketamine is contraindicated in patients with known hypersensitivity to the drug, uncontrolled hypertension, severe cardiovascular disease, and those with a history of psychosis where emergence phenomena could be hazardous. Clinical judgment should guide use in all cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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