Product image of Ketanest S (Esketamine Hydrochloride) supplied by GNH India

Ketanest S

Active Ingredient:
Esketamine Hydrochloride
Origin:
EU

Ketanest S (Esketamine Hydrochloride)

Esketamine Hydrochloride, the active ingredient in Ketanest S, is an NMDA receptor antagonist presented as a sterile solution for intramuscular and intravenous use. It provides dissociative anesthesia and analgesia for patients requiring induction of anesthesia, procedural sedation, or peri‑operative pain control.

GNH India supplies Ketanest S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for import and distribution, ensuring consistent product integrity across global markets.

Manufacturer / TM Owner

Pfizer Pharma Gmbh

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Indications & Clinical Uses

Esketamine Hydrochloride is employed in clinical settings where NMDA receptor blockade is required for anesthesia and analgesia.

  • Induction of anesthesia: Provides rapid onset of dissociative anesthesia for surgical procedures.
  • Procedural sedation: Enables safe sedation for diagnostic or minor therapeutic interventions.
  • Analgesia: Offers potent analgesic effect for peri‑operative pain management.

How It Works

  • Esketamine Hydrochloride acts as a non‑competitive antagonist at the NMDA (N‑methyl‑D‑aspartate) receptor, binding to the phencyclidine site within the ion channel. This blockade reduces excitatory glutamate transmission, producing dissociative anesthesia, analgesia, and amnesia while preserving airway reflexes. The rapid onset results from high lipid solubility, allowing swift penetration of the central nervous system.

Side Effects

Esketamine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Nausea
  • Vomiting
  • Elevated blood pressure
  • Headache
  • Perceptual disturbances (e.g., visual or auditory changes)

Serious or Rare Side Effects

  • Respiratory depression
  • Emergence delirium or severe agitation
  • Hypertensive crisis
  • Seizures
  • Psychotic reactions
  • Cardiac arrhythmias

Precautions & Warnings

Prior to administration, clinicians should consider several safety measures.

  • Patient assessment: evaluate cardiovascular and respiratory status before use.
  • Concurrent CNS depressants: avoid or monitor for additive effects.
  • History of substance abuse: use with caution and close observation.
  • Pregnancy and lactation: avoid unless benefits outweigh potential risks.
  • Monitoring: continuous vital‑sign monitoring during and after administration.
  • Store at below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Esketamine can interact with other medicines, influencing its safety and efficacy.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other NMDA antagonists: additive central nervous system depression.
  • Sympathomimetic agents: may exacerbate hypertension.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: may reduce anesthetic effect, requiring dose adjustment.
  • Opioids: increased risk of respiratory depression.
  • Antihypertensive drugs: may need titration to maintain blood pressure control.

Frequently Asked Questions

Ketanest S is indicated for the induction of general anesthesia, procedural sedation, and provision of analgesia in surgical or diagnostic settings where rapid, controllable dissociative anesthesia is required.

Esketamine acts as a non‑competitive antagonist at the NMDA receptor, blocking excitatory glutamate signaling in the brain. This results in dissociative anesthesia, analgesia, and amnesia while preserving airway reflexes.

The dose of Ketanest S is individualized by the prescribing clinician based on patient factors, the type of procedure, and the intended route of administration. Specific dosing regimens are determined at the point of care.

Safety data for esketamine during pregnancy and lactation are limited. It should be avoided unless the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To request Ketanest S, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with traditional volatile or intravenous anesthetics, esketamine provides rapid onset, profound analgesia, and maintains cardiovascular stability, but it may cause perceptual disturbances. Its NMDA‑blocking profile distinguishes it from GABA‑ergic agents such as propofol or benzodiazepines.

Ketanest S should be stored at temperatures below 25 °C, in its original packaging, protected from light and moisture. The solution must be kept in a controlled environment and inspected for particulate matter before use.

Ketanest S is administered by a trained healthcare professional via intramuscular or intravenous injection. The route, rate of injection, and total dose are determined by the clinician according to the procedural requirements.

Serious risks include respiratory depression, severe hypertension or hypertensive crisis, emergence delirium, seizures, psychotic reactions, and cardiac arrhythmias. Continuous monitoring of vital signs is essential during and after administration.

Ketanest S is contraindicated in patients with known hypersensitivity to esketamine or other NMDA antagonists, those with uncontrolled hypertension, severe cardiovascular disease, or a history of psychosis that could be exacerbated by dissociative agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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