Product image of Ketanov (Ketorolac Trometamol) supplied by GNH India

Ketanov

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketanov (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketanov, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular use. It provides short‑term management of moderate to severe pain, including post‑operative pain, in adult patients.

GNH India supplies Ketanov as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, including surgical centres and emergency departments.

Manufacturer / TM Owner

Terapia S.A.

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Indications & Clinical Uses

Ketorolac Trometamol is an NSAID used for acute pain management in the postoperative and trauma settings.

  • Post‑operative pain: provides rapid analgesia for up to 24‑48 hours after surgery.
  • Acute severe pain: reduces pain intensity following injury, dental procedures or other short‑term painful events.
  • Musculoskeletal injury: helps control pain and inflammation after strains or sprains.

How It Works

  • Ketorolac Trometamol exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, nociceptor sensitization, and the perception of pain at the site of injury.

Side Effects

Adverse reactions may occur with any dose of ketorolac.

Common Side Effects

  • Injection‑site pain or irritation.
  • Nausea or vomiting.
  • Headache.
  • Dizziness.
  • Mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Renal impairment or failure.
  • Severe allergic reactions such as anaphylaxis.
  • Gastrointestinal ulceration or bleeding.
  • Cardiovascular thrombotic events (e.g., myocardial infarction, stroke).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before using Ketanov, clinicians should consider several safety measures.

  • Assess renal function: avoid in patients with severe renal impairment.
  • Monitor for bleeding: use cautiously with anticoagulants or antiplatelet agents.
  • Avoid in patients with known hypersensitivity to NSAIDs or aspirin.
  • Limit duration: restrict treatment to five days or less to minimise adverse events.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketorolac can interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may reduce renal function when combined.
  • Diuretics: can impair renal clearance of ketorolac.
  • Lithium: may increase serum lithium concentrations, requiring monitoring.

Frequently Asked Questions

Ketanov contains ketorolac trometamol, an NSAID indicated for the short‑term management of moderate to severe pain, especially after surgery or other acute painful procedures. It is administered by intramuscular injection and is intended for use in adult patients when rapid analgesia is required.

Ketorolac trometamol works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for the production of prostaglandins. By reducing prostaglandin synthesis, the drug diminishes inflammation, lowers the sensitivity of pain receptors, and provides effective analgesia.

The specific dose and frequency of Ketanov are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and overall treatment plan. Healthcare professionals follow local guidelines and product labeling to set an appropriate regimen.

The safety of ketorolac trometamol in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Ketanov product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Ketanov (ketorolac trometamol) is distinguished by its potent analgesic effect, often comparable to opioid analgesics for short‑term use, whereas many other NSAIDs provide milder pain relief. However, its risk profile for gastrointestinal bleeding and renal effects is higher, so it is typically reserved for brief periods and monitored closely.

Ketanov should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from direct sunlight, moisture, and extreme temperature fluctuations. Do not freeze the solution, and keep it out of reach of children.

Ketanov is supplied as a sterile injectable solution for intramuscular injection. The healthcare professional selects an appropriate injection site, typically the gluteal or deltoid muscle, and administers the dose using aseptic technique according to the prescribed regimen.

The most serious risks include severe bleeding, gastrointestinal ulceration or perforation, renal failure, cardiovascular thrombotic events such as myocardial infarction or stroke, and rare but life‑threatening allergic reactions like anaphylaxis. Patients should be monitored closely for signs of these complications.

Ketanov is contraindicated in patients with known hypersensitivity to ketorolac, other NSAIDs, or aspirin; those with active gastrointestinal bleeding or ulcer disease; severe renal impairment; and patients who have recently undergone coronary artery bypass graft surgery. It should also be avoided in individuals at high risk for cardiovascular events unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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