Ketanov (Ketorolac Trometamol)

Ketanov, a nonsteroidal anti‑inflammatory analgesic, is indicated for conditions that require rapid pain control.

• Postoperative pain: provides effective relief after surgical procedures.
• Acute moderate‑to‑severe pain: reduces pain intensity in short‑term settings.
• Short‑term pain management: used for brief periods when stronger analgesia is needed.

• Ketorolac Trometamol inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By lowering prostaglandin synthesis, it reduces inflammation, nociceptor sensitisation and the perception of pain, delivering rapid analgesic effect after oral administration.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Dyspepsia: stomach discomfort or indigestion.
• Nausea: feeling of sickness.
• Headache: mild to moderate head pain.
• Dizziness: transient light‑headedness.
• Diarrhoea: loose stools.
• Elevated blood pressure: modest rise in systolic/diastolic values.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Renal impairment: reduced kidney function.
• Severe hypersensitivity reactions: rash, angioedema, anaphylaxis.
• Hepatotoxicity: abnormal liver enzymes.
• Cardiovascular events: myocardial infarction or stroke.
• Hematologic abnormalities: thrombocytopenia or bleeding disorders.

Before prescribing Ketanov, clinicians should evaluate patient‑specific risk factors and monitor for potential complications.

• Renal function: assess baseline creatinine and avoid in severe renal impairment.
• Gastrointestinal risk: avoid in patients with active ulcer disease or history of GI bleeding.
• Cardiovascular disease: use cautiously in patients with coronary artery disease or uncontrolled hypertension.
• Concomitant NSAIDs or anticoagulants: increase bleeding risk; monitor closely.
• Pregnancy and lactation: avoid unless benefits outweigh risks; data are limited.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Ketorolac can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): increased bleeding tendency.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal perfusion, especially in dehydrated patients.
• Diuretics: potential for reduced renal function.
• Lithium: NSAIDs can raise lithium levels, risking toxicity.
• Methotrexate: decreased clearance may lead to toxicity.