Product image of Ketanov (Ketorolac Trometamol) supplied by GNH India

Ketanov

Active Ingredient:
Ketorolac Trometamol
Origin:
EU

Ketanov (Ketorolac Trometamol)

Ketorolac Trometamol, the active ingredient in Ketanov, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It provides short‑term relief of moderate to severe acute pain, including post‑operative pain, in adult patients, and is typically prescribed for up to five days to minimize risk of adverse events.

GNH India supplies Ketanov as a licensed, GDP‑compliant international pharmaceutical product, sourced from EU manufacturers and distributed to hospitals, pharmacies and clinics worldwide, adhering to stringent quality and regulatory standards.

Manufacturer / TM Owner

Terapia S.A.

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Indications & Clinical Uses

Ketanov (ketorolac trometamol) is used to manage pain by inhibiting prostaglandin synthesis in the cyclooxygenase pathway.

  • Moderate to severe acute pain: provides rapid analgesia for conditions such as renal colic or musculoskeletal injury.
  • Post‑operative pain: reduces pain intensity after surgical procedures, facilitating early mobilization.
  • Short‑term pain management: offers effective relief when non‑opioid therapy is required for up to five days.

How It Works

  • Ketorolac trometamol exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin levels reduces peripheral sensitization and inflammation, producing potent analgesic activity comparable to that of opioid analgesics for short‑term use, while avoiding opioid‑related side effects but potentially affecting platelet function and gastric mucosa.

Side Effects

Ketorolac trometamol may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea or dyspepsia: mild gastrointestinal upset.
  • Headache: transient head pain.
  • Dizziness: occasional vertigo or light‑headedness.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: risk of serious hemorrhage.
  • Acute kidney injury: rapid decline in renal function.
  • Severe hypersensitivity reactions: anaphylaxis or skin rash.

Precautions & Warnings

When prescribing Ketanov, clinicians should consider several precautionary measures to minimize risk.

  • Assess renal function: avoid use in patients with severe renal impairment or dehydration.
  • Evaluate bleeding risk: contraindicated in active gastrointestinal ulceration or coagulopathy.
  • Limit duration: restrict therapy to the shortest possible period, generally not exceeding five days.
  • Avoid concomitant NSAIDs: concurrent use increases risk of gastrointestinal and renal adverse events.
  • Monitor cardiovascular status: use cautiously in patients with known cardiovascular disease.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Ketorolac trometamol can interact with other medicines, altering its safety or effectiveness.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, direct oral anticoagulants): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs) or SNRIs: heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal perfusion, especially in volume‑depleted patients.
  • Diuretics: potential for renal function decline when combined with NSAIDs.
  • Lithium: NSAIDs can raise lithium serum levels, requiring monitoring.

Frequently Asked Questions

Ketanov contains ketorolac trometamol, an NSAID indicated for short‑term relief of moderate to severe acute pain and for managing pain after surgical procedures. It is prescribed when rapid analgesia is needed and is typically limited to a few days of therapy.

Ketorolac trometamol works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the formation of prostaglandins. Lower prostaglandin levels diminish inflammation and peripheral pain signaling, producing a potent analgesic effect comparable to that of opioids for brief use.

The specific dose of Ketanov is determined by the prescribing clinician based on the patient’s condition, age, renal function and other factors. Healthcare professionals set the appropriate strength, frequency and duration in accordance with local prescribing guidelines.

Safety data for ketorolac trometamol in pregnancy and lactation are limited. Because NSAIDs can affect fetal development and may pass into breast milk, the drug is generally avoided unless the potential benefit outweighs the risk and it is prescribed by a qualified practitioner.

To request Ketanov, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketanov offers analgesic potency similar to that of moderate‑dose opioids but without opioid‑related respiratory depression. Compared with other NSAIDs, ketorolac provides a faster onset and stronger pain relief, yet it carries a higher risk of renal and gastrointestinal adverse effects, so its use is limited to short courses.

Ketanov should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct light, and ensure they are out of reach of children.

Ketanov is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and whether to use it with meals to reduce stomach irritation.

The most serious risks include gastrointestinal bleeding or ulceration, acute kidney injury, and severe hypersensitivity reactions such as anaphylaxis. Patients with existing ulcer disease, renal impairment or a history of allergic reactions should be evaluated carefully before use.

Ketanov is contraindicated in patients with active gastrointestinal bleeding or ulcer disease, severe renal impairment, known hypersensitivity to ketorolac or other NSAIDs, and in those receiving other NSAIDs or anticoagulants where bleeding risk is high. It should also be avoided in patients with uncontrolled hypertension or significant cardiovascular disease unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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