Product image of Ketazed (Ketotifen Hydrogen Fumarate) supplied by GNH India

Ketazed

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Ketazed (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketazed, is an antihistamine (H1 receptor antagonist) presented as an ocular solution for eye‑drop use. It is indicated for the relief of allergic conjunctivitis and associated ocular itching, redness, and watery discharge in patients with seasonal or perennial eye allergies.

GNH India supplies Ketazed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable access to this EU‑approved OTC ocular antihistamine for eye‑care professionals and patients, with consistent quality and regulatory compliance.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

  • Ketazed is used to manage allergic eye conditions by blocking histamine activity in the conjunctiva.
  • Allergic conjunctivitis: reduces itching, redness, and tearing associated with seasonal or perennial eye allergies.
  • Seasonal allergic eye disease: provides symptom relief during pollen or allergen exposure.
  • Contact lens‑related ocular itching: alleviates discomfort caused by allergic reactions in contact lens wearers.

How It Works

  • Ketotifen hydrogen fumarate stabilizes mast cells and competitively antagonizes H1 histamine receptors on ocular tissues. By preventing degranulation, it limits the release of histamine, leukotrienes, and other inflammatory mediators, thereby decreasing vascular permeability and nerve stimulation in the conjunctiva, which reduces itching, redness, and swelling. The combined mast‑cell stabilization and antihistaminic action produces rapid relief of ocular allergy symptoms.

Side Effects

Ketazed may cause ocular and systemic adverse reactions, most of which are mild and transient.

Common Side Effects

  • Eye irritation or burning sensation
  • Transient blurred vision
  • Mild headache

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling of eyelids or face
  • Corneal ulcer or keratitis
  • Significant increase in intra‑ocular pressure

Precautions & Warnings

  • Before using Ketazed, consider the following safety measures.
  • Hypersensitivity: discontinue use if signs of allergic reaction appear.
  • Contact lens use: avoid wearing contact lenses during treatment and for at least 15 minutes after instillation.
  • Dosage: use only the prescribed number of drops as directed by a healthcare professional.
  • Monitoring: seek medical advice if symptoms worsen or persist beyond a few days.
  • Driving or operating machinery: exercise caution if blurred vision occurs.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Ketazed can interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Systemic antihistamines: concurrent use may increase sedation and ocular dryness.
  • CYP450 inhibitors (e.g., ketoconazole): may raise systemic exposure of ketotifen.
  • Other mast‑cell stabilizers: combined use may increase risk of ocular irritation.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may augment intra‑ocular pressure when used together.
  • Contact lens cleaning solutions: can affect drug stability; avoid mixing.
  • Other ocular decongestants: may cause additive vasoconstriction.

Frequently Asked Questions

Ketazed is an ocular antihistamine indicated for the treatment of allergic conjunctivitis and related eye symptoms such as itching, redness, and tearing. It is used in patients who experience seasonal or perennial eye allergies and provides relief by targeting the underlying histamine response in the eye.

Ketotifen hydrogen fumarate works by stabilizing mast cells and blocking H1 histamine receptors on ocular tissues. This dual action prevents the release of histamine and other inflammatory mediators, reducing vascular permeability and nerve irritation in the conjunctiva, which alleviates itching, redness, and swelling.

The specific dosing regimen for Ketazed is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and response to therapy. Patients should follow the exact instructions provided on the prescription label and consult their clinician for any dosing questions.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketazed, as the prescriber will decide whether it is appropriate.

To order Ketazed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any required import documentation.

Ketazed (ketotifen hydrogen fumarate) offers both mast‑cell stabilization and H1‑receptor antagonism, providing a broader mechanism of action than many single‑target antihistamines. This can result in faster and more sustained symptom relief for allergic conjunctivitis, though individual response may vary and clinicians choose therapy based on patient needs.

Ketazed should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Do not use the product if the solution appears discoloured or if the container is damaged.

Ketazed is administered as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a small pocket, and instill the prescribed number of drops into the conjunctival sac. After dosing, close the eyes gently and avoid blinking excessively for a few seconds.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, corneal ulcer or keratitis, and a significant increase in intra‑ocular pressure that could threaten vision. Patients should seek immediate medical attention if they experience swelling of the eyelids, intense eye pain, vision changes, or signs of systemic allergy.

Ketazed should not be used by individuals with known hypersensitivity to ketotifen, its salts, or any excipients in the formulation. Patients with active ocular infections, severe ocular surface disease, or uncontrolled glaucoma should consult their eye‑care professional before using this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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