Product image of Ketazed (Ketotifen Hydrogen Fumarate) supplied by GNH India

Ketazed

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Ketazed (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketazed, is an antihistamine / mast cell stabilizer presented as an ophthalmic solution for ocular use. It is employed to relieve symptoms of allergic conjunctivitis and related seasonal eye allergies in patients of all ages. The formulation is designed for easy instillation and rapid absorption on the ocular surface, providing prompt relief.

GNH India supplies Ketazed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, transplant centres and clinics worldwide, ensuring quality‑assured batches that meet EU regulatory standards.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

Ketazed, an antihistamine and mast cell stabilizer, is used to manage allergic eye conditions.

  • Allergic conjunctivitis: reduces itching, redness, and watery discharge associated with allergic eye inflammation.
  • Seasonal allergic eye disease: alleviates ocular symptoms triggered by seasonal allergens such as pollen.
  • Vernal keratoconjunctivitis: helps control chronic inflammation and photophobia in this severe, recurrent eye allergy.

How It Works

  • Ketotifen hydrogen fumarate blocks H1 histamine receptors on ocular tissues, preventing histamine‑mediated vasodilation and itching. Simultaneously, it stabilizes mast cells, inhibiting the release of inflammatory mediators such as leukotrienes and prostaglandins, thereby reducing ocular inflammation and allergic symptomatology.

Side Effects

Ketazed may cause ocular and systemic reactions in some patients.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Transient blurred vision.
  • Mild eye irritation or redness.
  • Headache.
  • Dry eye sensation.
  • Temporary tearing.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling of the eyelids.
  • Corneal ulcer or epithelial defect.
  • Significant increase in intra‑ocular pressure.
  • Vision loss.
  • Persistent ocular edema.
  • Systemic hypersensitivity (rash, urticaria).

Precautions & Warnings

Before using Ketazed, consider the following safety measures.

  • Assess patient history: check for hypersensitivity to ketotifen or related antihistamines.
  • Avoid use in active eye infection: postpone treatment until infection resolves.
  • Use with caution in glaucoma patients: monitor intra‑ocular pressure regularly.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketazed can interact with other medications; monitor patients accordingly.

Major Interactions (Avoid)

  • Concurrent systemic antihistamines or mast cell stabilizers: may increase risk of additive ocular irritation.
  • MAO inhibitors: potential for enhanced systemic antihistamine effects.

Moderate Interactions (Monitor Closely)

  • Topical non‑steroidal anti‑inflammatory eye drops: may increase local irritation.
  • Beta‑blocker eye drops (e.g., timolol): monitor intra‑ocular pressure.
  • Corticosteroid eye preparations: assess for compounded immunosuppressive effects.

Frequently Asked Questions

Ketazed is an ophthalmic solution containing ketotifen hydrogen fumarate. It is used to treat allergic eye conditions such as allergic conjunctivitis, seasonal allergic eye disease, and vernal keratoconjunctivitis by reducing itching, redness, and swelling.

Ketotifen hydrogen fumarate works by blocking H1 histamine receptors on ocular tissues, preventing histamine‑induced itching and vasodilation. It also stabilizes mast cells, limiting the release of inflammatory mediators that contribute to eye allergy symptoms.

The appropriate dosing regimen for Ketazed is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical response. Patients should follow the specific instructions provided by their clinician.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketazed.

To order Ketazed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Ketazed combines antihistamine and mast‑cell‑stabilizing actions in a single ophthalmic solution, offering both rapid symptom relief and longer‑term inflammation control. Compared with agents that provide only antihistamine activity, Ketazed may reduce the need for multiple eye drops.

Ketazed should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from direct light and moisture, and discard any solution that appears discolored or contains particles.

Ketazed is applied as eye drops. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. Close the eyes gently for a few seconds to allow absorption.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, corneal ulceration, significant increase in intra‑ocular pressure, and vision loss. Patients should seek immediate medical attention if they experience sudden swelling, pain, or visual changes.

Ketazed should not be used by individuals with known hypersensitivity to ketotifen, other antihistamines, or any component of the formulation. Patients with active ocular infections or uncontrolled glaucoma should avoid use until evaluated by an eye care professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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