Product image of Ketazed (Ketotifen Hydrogen Fumarate) supplied by GNH India

Ketazed

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Ketazed (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketazed, is an antihistamine / mast cell stabilizer presented as an ocular solution for ocular use. It treats allergic conjunctivitis and ocular itching or redness caused by allergy in both adults and children.

GNH India supplies Ketazed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

  • Ketazed is used to manage ocular allergic conditions by stabilising mast cells and blocking histamine effects.
  • Allergic conjunctivitis: reduces inflammation and discomfort in the eyes caused by allergens.
  • Ocular itching due to allergy: relieves itching sensations associated with allergic reactions.
  • Redness from allergic eye disease: diminishes visible redness and swelling in the conjunctiva.

How It Works

  • Ketotifen hydrogen fumarate acts as a dual‑action agent. It stabilises mast cells, preventing the release of histamine and other inflammatory mediators, and it competitively blocks histamine H1 receptors on ocular tissues. This combined effect reduces the cascade of allergic inflammation in the eye, leading to decreased itching, redness, and swelling.

Side Effects

Ketazed may cause ocular or systemic reactions, although many patients experience no adverse events.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Temporary blurred vision.
  • Mild eye irritation or foreign‑body feeling.
  • Slight headache.
  • Dryness of the ocular surface.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling of the eyelids or face.
  • Persistent eye pain or significant vision changes.
  • Corneal ulceration or infection.
  • Acute angle‑closure glaucoma.
  • Significant systemic hypersensitivity (rash, urticaria).

Precautions & Warnings

  • Before using Ketazed, consider the following safety measures.
  • Avoid use in patients with known hypersensitivity to ketotifen or any formulation component: discontinue if reaction occurs.
  • Do not apply if the eye is infected or has a corneal ulcer: seek professional evaluation first.
  • Use with caution in patients with narrow-angle glaucoma: monitor intra‑ocular pressure.
  • Pregnancy and breastfeeding status unknown: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketazed may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Concurrent use of other mast cell stabilizers (e.g., cromolyn) may increase local irritation.
  • Co‑administration with potent topical corticosteroids may mask signs of infection.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines (e.g., cetirizine) could enhance sedation if systemic absorption occurs.
  • Contact lens wearers: may experience reduced lens tolerance; advise removal before instillation.
  • Use with other ophthalmic solutions containing preservatives: monitor for additive irritation.

Frequently Asked Questions

Ketazed is an ophthalmic solution containing ketotifen hydrogen fumarate. It is used to relieve symptoms of ocular allergy such as itching, redness, and swelling caused by allergic conjunctivitis. The medication works locally in the eye to reduce inflammation and improve comfort.

Ketotifen hydrogen fumarate stabilises mast cells, preventing them from releasing histamine and other inflammatory mediators. It also blocks histamine H1 receptors on ocular tissues. By limiting both the release and the action of histamine, the drug reduces the allergic response in the eye.

The dosing regimen for Ketazed is determined by the prescribing clinician based on the severity of the allergic eye condition and the patient’s age. Typically, one or two drops are instilled in the affected eye(s) as directed, but the exact schedule should follow the healthcare professional’s instructions.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketazed.

To order Ketazed, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketazed combines mast‑cell stabilisation with H1‑receptor blockade, offering both preventive and symptomatic relief. Some alternatives provide only antihistamine activity, which may relieve itching but not prevent mediator release. The dual mechanism of ketotifen can give broader control of allergic eye symptoms.

Ketazed should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct sunlight and moisture, and avoid freezing. Do not use the product if the solution appears discoloured or if the container is damaged.

Ketazed is applied as an eye drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a small pocket, and place the prescribed number of drops into the conjunctival sac. Close the eye gently and avoid blinking excessively for a few seconds.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, significant eye pain, sudden vision loss, corneal ulceration, or acute angle‑closure glaucoma. Any of these symptoms require immediate medical attention and discontinuation of the product.

Ketazed should not be used by individuals with a known hypersensitivity to ketotifen hydrogen fumarate or any excipients in the formulation. It is also contraindicated in eyes with active infection, corneal ulceration, or in patients with narrow‑angle glaucoma unless specifically advised by an eye‑care professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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