Product image of Ketazed (Ketotifen Hydrogen Fumarate) supplied by GNH India

Ketazed

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Ketazed (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketazed, is an antihistamine; mast cell stabilizer presented as an ophthalmic solution for ocular use. It is employed to relieve allergic inflammation of the eye, reducing itching, redness and watery discharge in patients with seasonal or perennial eye allergies.

GNH India supplies Ketazed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

Ketazed is used to manage ocular allergic conditions by targeting histamine‑mediated pathways.

  • Allergic conjunctivitis: alleviates redness, itching and swelling of the conjunctiva.
  • Ocular itching due to allergy: reduces the urge to rub or scratch the eyes.
  • Redness of the eye caused by allergy: diminishes visible hyperemia and discomfort.

How It Works

  • Ketotifen hydrogen fumarate antagonizes histamine H1 receptors on ocular tissues and stabilizes mast cells, inhibiting degranulation. This dual action blocks the release of histamine and other inflammatory mediators such as leukotrienes and prostaglandins, thereby reducing vascular permeability, edema and sensory nerve activation in the eye.

Side Effects

Ketazed may cause ocular and systemic reactions, most of which are mild and transient.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Temporary blurred vision.
  • Mild ocular irritation or foreign‑body feeling.
  • Slight headache.
  • Dryness of the eye surface.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling of eyelids.
  • Corneal ulcer or epithelial defect.
  • Persistent increase in intra‑ocular pressure.
  • Vision loss or significant visual disturbance.
  • Acute iritis or uveitis.

Precautions & Warnings

Before using Ketazed, consider the following safety measures.

  • Pregnancy: consult a healthcare professional; safety data are limited.
  • Breastfeeding: discuss potential exposure with a physician.
  • Pre‑existing eye conditions: inform the prescriber of glaucoma, cataract or recent eye surgery.
  • Concomitant ocular medications: avoid simultaneous use unless directed by a clinician.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketazed can interact with other agents that affect ocular physiology.

Major Interactions (Avoid)

  • Concurrent use of other mast cell stabilizers or antihistamine eye drops may increase local irritation.
  • Systemic antihistamines that cause dry eye may exacerbate discomfort.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: monitor intra‑ocular pressure when combined.
  • Beta‑blocker eye drops: watch for additive effects on pupil size.
  • Preservative‑containing solutions: may increase risk of ocular surface toxicity.

Frequently Asked Questions

Ketazed is an ophthalmic solution containing ketotifen hydrogen fumarate that is used to treat allergic eye conditions such as allergic conjunctivitis, ocular itching and redness caused by environmental allergens.

Ketotifen hydrogen fumarate blocks histamine H1 receptors and stabilises mast cells in the ocular tissues, preventing the release of histamine and other inflammatory mediators that cause itching, swelling and redness.

The dosing regimen for Ketazed is determined by the prescribing clinician based on the severity of symptoms and patient response. Patients should follow the specific instructions provided on the prescription label.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketazed.

To order Ketazed, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketazed combines antihistamine activity with mast‑cell stabilisation, offering both immediate symptom relief and longer‑term reduction of allergic inflammation. Some alternatives provide only H1‑receptor blockade, which may require more frequent dosing for comparable control.

Ketazed should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct sunlight and moisture, and discard any solution that appears discoloured or contaminated.

Ketazed is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, instill the prescribed number of drops, and close the eyes gently for a few seconds. Contact lenses should be removed before use and re‑inserted after the recommended waiting period.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, corneal ulceration, and a sustained increase in intra‑ocular pressure that could threaten vision. Any sudden worsening of eye symptoms should prompt immediate medical evaluation.

Ketazed should be avoided in individuals with known hypersensitivity to ketotifen, any component of the formulation, or those with active severe ocular infections unless directed by an eye‑care specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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